CRYAB Antibody
- Known as:
- CRYAB Antibody
- Catalog number:
- csb-pa006008ha01hu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- CRYAB Antibody
Related genes to: CRYAB Antibody
- Gene:
- CRYAB NIH gene
- Name:
- crystallin alpha B
- Previous symbol:
- CRYA2
- Synonyms:
- HSPB5
- Chromosome:
- 11q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1987-09-11
- Date modifiied:
- 2019-04-23
Related products to: CRYAB Antibody
Related articles to: CRYAB Antibody
- Body size is a key economic trait influencing the profitability of farmed animals. This study used genome-wide association studies (GWAS) to identify five single nucleotide polymorphisms (SNPs) significantly associated with body size in the Tibetan sheep population, advancing molecular breeding and providing a basis for genomic selection. These SNPs are located within five candidate genes. SNaPshot validated GWAS results, demonstrating significant correlations between candidate SNPs and body size traits in Tibetan sheep. Concurrently, hematoxylin and eosin staining, alongside muscle fiber analysis, confirmed pronounced morphological differences in muscle tissue between sheep of varying conformation. Therefore, transcriptome and proteomics were performed on the longest dorsi muscle from large and small Tibetan sheep of both sexes. The transcriptome, together with weighted gene co-expression network analysis (WGCNA), identified VEPH1 and PRKG1 as core genes regulating body characteristics in Tibetan sheep through their involvement in the PI3K-Akt signaling pathway and pathways related to fat deposition. The integrative analyses demonstrated significantly different expression of CARNS1 and CRYAB at both transcriptional and protein levels between the muscles of large- and small-sized Tibetan sheep of both sexes, suggesting their importance in body size traits by influencing muscle morphology. This study provides valuable genomic resources that advance sheep genetics research. - Source: PubMed
Publication date: 2026/09/04
Liu DehuiLi XueTian FeiLi XuexiaLi WenxiaHan BuyingJiang MingLiu YanlanHu XiliuXiang XueMa WulongBao GuangcaiLi RongBao GuoxiangLiu SijiaZhao KaiTian Dehong - Emerging evidence indicates that coagulation-related molecular programs are associated with thrombosis, tumor progression, and molecular dysregulation in gastric cancer (GC). However, thrombosis-associated molecular features in GC and their potential links to inherited susceptibility remain insufficiently understood. Integrated analyses of transcriptomic data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were performed to identify thrombosis-associated genes and establish a machine learning-based prognostic signature. Genome-wide association study (GWAS), expression quantitative trait loci (eQTL), transcriptome-wide association study (TWAS), and Mendelian randomization (MR) analyses were conducted to investigate susceptibility-associated transcriptional programs in GC. Functional assays were used to evaluate candidate genes associated with malignant phenotypes. Single-cell RNA sequencing (scRNA-seq) and cell-cell communication analyses were further performed to characterize cell-type-specific expression patterns and potential intercellular interactions. A total of 22 differentially expressed thrombosis-associated genes were identified, and a prognostic signature comprising 14 genes was established. The signature stratified patients into high- and low-risk groups and showed prognostic performance in both the training and validation cohorts. Integrative GWAS, eQTL, and TWAS analyses identified susceptibility-associated transcriptional programs that were positively correlated with the thrombosis-associated risk score. Silencing ACTN2 and CRYAB significantly reduced GC cell migration and invasion. scRNA-seq analysis revealed relatively high CRYAB expression in neutrophils, and CellChat analysis suggested potential neutrophil-B cell interactions involving COLLAGEN-related signaling. This integrative multi-omics study identified a thrombosis-associated molecular signature linked to prognosis and germline susceptibility-associated transcriptional programs in GC. ACTN2 and CRYAB may represent candidate genes associated with GC cell migration and invasion, while single-cell analysis suggested potential immune-related communication features. - Source: PubMed
Lu XiaogangSun LinJin FujunCheng BiaoHuang YingTang YuzhuNie XiaolongGao Feng - Meat quality is an important economic trait in beef cattle and is influenced by breed-related metabolic characteristics. Yanbian cattle (YB) are valued for desirable meat quality, whereas Yanhuang cattle (YH), developed using Limousin cattle as the paternal line and Yanbian cattle as the maternal line, exhibit improved growth performance and carcass yield. However, the molecular basis underlying metabolic variation between these two genetically related cattle populations remains unclear. In this study, longissimus thoracis muscle samples from six animals per breed were analyzed using LC-MS/MS-based metabolomics and GC×GC-TOF/MS-based volatile compound profiling, and a subset of three samples per breed from the same cohort was selected for transcriptomic sequencing. A total of 1697 metabolites were detected. Based on the screening criteria of VIP > 1 and < 0.05, 202 candidate metabolites were identified, among which 11 remained statistically significant after false discovery rate (FDR) correction. Volatile compound profiling detected 1333 and 1516 compounds in YB and YH, respectively, of which 809 were shared. Based on the same screening criteria, 39 candidate volatile compounds were identified, although none remained significant after FDR correction. Transcriptomic analysis identified 360 differentially expressed genes using |logFC| > 1 and adjusted < 0.05, with enrichment mainly observed in pathways associated with carbohydrate metabolism, lipid turnover, and energy utilization. Integrative analyses indicated that amino acid-related metabolites, including phenylpyruvate, 2-aminobenzoic acid, and asparagine, were more closely associated with candidate volatile compounds than metabolites involved in central carbon metabolism. Several genes involved in lipid metabolism, energy metabolism, and muscle structure, including , , , , , , , and , were associated with distinct metabolic modules. These findings provide an exploratory view of breed-related metabolic variation and identify candidate molecular features for future validation. - Source: PubMed
Publication date: 2026/08/10
Lyu YangZhu ZhiweiZhao BaoxinRen ZezhuZhou MengYu JingDing HeLiu HongyuFang YiZhao JingLyu Wenfa - Protein quality control is critical for maintaining sarcomere structure and function in cardiomyocytes. Mutations in protein quality control pathway proteins, namely, CRYAB-R120G (arginine to glycine at position 120) and BAG3-P209L (proline to lysine at position 209), induce protein aggregates and cardiomyopathy in humans. Novel observations in yeast demonstrate mitochondrial uptake of cytosolic protein aggregates. We hypothesized that mitochondrial uptake of cytosolic protein aggregates, and their removal by mitophagy, a lysosomal degradative pathway, facilitates cytosolic protein quality control in cardiomyocytes. - Source: PubMed
Publication date: 2026/08/26
Rawnsley David RIslam MoydulZhao ChenGuan XuminKargar Gaz Kooh YasamanMendoza AdelitaNavid HonoraKumari MinuPandi PhalgunMurphy John TNigro JessKovacs AttilaGreenberg LinaMani KartikGreenberg MichaelHuebsch NathanielMa XiucuiDiwan Abhinav - Vascular calcification (VC) is a life-threatening complication of chronic kidney disease (CKD) driven by vascular smooth muscle cell (VSMC) osteogenic transdifferentiation. Anoikis, a form of adhesion-dependent apoptosis, is involved in cardiovascular remodeling, yet its regulatory role in CKD-associated VC remains unexplored. - Source: PubMed
Publication date: 2026/08/24
Chen DandanDai TianzengYu WenfengXie Xi'naLi RuiWang Yan