RORA antibody - N-terminal region (P100794_T100)
- Known as:
- RORA (anti-) - N-terminal region (P100794_T100)
- Catalog number:
- p100794_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- RORA antibody - N-terminal region (P100794_T100)
Related genes to: RORA antibody - N-terminal region (P100794_T100)
- Gene:
- RORA NIH gene
- Name:
- RAR related orphan receptor A
- Previous symbol:
- -
- Synonyms:
- RZRA, ROR1, ROR2, ROR3, NR1F1
- Chromosome:
- 15q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-04-13
- Date modifiied:
- 2016-10-05
Related products to: RORA antibody - N-terminal region (P100794_T100)
Related articles to: RORA antibody - N-terminal region (P100794_T100)
- The aging of hematopoietic stem cells (HSCs) impairs their regenerative and self-renewal capacities, contributing to immune dysfunction and hematologic diseases, yet safe and effective rejuvenation strategies remain elusive. - Source: PubMed
Publication date: 2026/03/17
Feng YunyuLi NingWang NanHe WeiLi HongjianCui XueWang BochuanQin RunkuanQiu HuandiQiu QiangZheng LiSun YuanyuanHe LinyePan CongSu AnpingLi ZhihuiHu Yiguo - Following extensive liver resections, diminished liver regeneration impairs the maintenance or restoration of sufficient functional liver mass. Currently, effective therapies to restore liver regeneration are lacking, rendering liver transplantation the sole treatment option for end-stage liver disease. Therefore, it is imperative to elucidate the regulatory mechanisms underlying liver regeneration. In this study, we employed a multi-omics approach integrating Hi-C, RNA-seq, and ATAC-seq to dissect the early regulatory mechanisms of liver regeneration in rats and mice. Our results indicate that immune and inflammatory processes are markedly enriched during the early phase of regeneration, accompanied by upregulation of glucocorticoids (GCs) and their receptor (GR). First, the expression dynamics of the GC-related circadian gene Nr1d1 and its regulatory network-including Nfκbiα, Arntl, Clock, and Rora-align with chromatin reorganization, leading us to propose that the GC-GR-Nr1d1 axis is involved in maintaining liver homeostasis. Second, the GR-regulated FoxO family is significantly enriched, and the FoxO-associated gene Klf2 exhibits coordinated changes in expression, chromatin accessibility, and chromatin structure. Functional experiments demonstrate that Klf2 negatively regulates hepatocyte proliferation. Hence, we propose the GC-GR-FoxOs-Klf2 axis acts as a checkpoint in hepatocyte proliferation, preventing premature activation of proliferation- and cell cycle-related genes and ensuring orderly and efficient liver regeneration. Our findings on the role of GCs in liver regeneration may further support their future therapeutic application in liver diseases such as liver fibrosis, alcoholic cirrhosis, and hepatocellular carcinoma (HCC). - Source: PubMed
Publication date: 2026/04/13
Ye BingyuXie DejianShen WenlongYue MeijuanJin QinpengGuo XinjieZhang YanLi PingZhao Zhihu - Ankylosing spondylitis (AS) is a chronic inflammatory disorder with poorly defined pathogenic mechanisms. The integrated stress response (ISR), an evolutionarily conserved signaling network, is implicated in AS development. This research endeavored to identify biomarkers for AS, thereby offering novel targets and approaches for therapeutic intervention. - Source: PubMed
Publication date: 2026/03/26
Wang ShuaiZhu JingliangZhang HonghuiHu ShengxuanMei JiaxinZhou ChusongShi Benchao - RORA can affect lambing numbers and cell proliferation in sheep. MiRNAs are important for post-transcriptional gene regulation, but how they function during follicular development is currently unknown. In this study, miR-4670-3p was identified as a key microRNA targeting RORA using bioinformatics analysis. In ovarian tissues from sheep with high-fertility, miR-4670-3p abundance was substantially increased in comparison to the low-fertility group, demonstrating an inverse association with RORA levels. To validate this interaction, dual luciferase assay showed that miR-4670-3p suppressed RORA expression. To explore the functional roles of miR-4670-3p and RORA during development and growth of sheep granulosa cells, we generated specific overexpression and interference (inhibition) plasmids targeting each molecule. Enhanced expression of miR-4670-3p markedly increased the rate of granulosa cell proliferation, whereas inhibition of miR-4670-3p repressed granulosa cell proliferation. RORA overexpression or inhibition exhibited opposite effects to those mediated by miR-4670-3p on granulosa cell proliferation. Moreover, RORA overexpression also suppressed the expression of TGF-β/SMAD signalling pathway marker genes, whereas RORA inhibition produced the opposite effect. Co-transfection experiments with miR-4670-3p and RORA suggested that miR-4670-3p modulates granulosa cell proliferation through direct targeting of RORA to modulate the TGF-β/SMAD signaling pathway. Collectively, our findings deepen the understanding of how microRNAs influence sheep fertility and elucidate the molecular mechanism whereby miR-4670-3p promoted granulosa cell proliferation through targeting the RORA/TGF-β/SMAD molecular axis. - Source: PubMed
Publication date: 2026/04/06
Han HaiyinGu ShiyuChi RunqingPu XiufenSong YizeXiang YupingLiu YufangChu Mingxing - Nuclear receptors are modular transcription factors regulated by ligands, chromatin context, and expression level. Wang et al. 2026, in this issue of Stem Cell Reports show that Rora controls OKS-mediated reprogramming in a dose-dependent manner: moderate expression enhances iPSC formation, while high levels inhibit it, linking quantitative Rora control to immune and WNT signaling during cell fate conversion. - Source: PubMed
Publication date: 2026/04/02
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