SOX8 antibody - C-terminal region (P100732_P050)
- Known as:
- SOX8 (anti-) - C-terminal region (P100732_P050)
- Catalog number:
- p100732_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- SOX8 antibody - C-terminal region (P100732_P050)
Related genes to: SOX8 antibody - C-terminal region (P100732_P050)
- Gene:
- SOX8 NIH gene
- Name:
- SRY-box 8
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-03-14
- Date modifiied:
- 2015-11-23
Related products to: SOX8 antibody - C-terminal region (P100732_P050)
Related articles to: SOX8 antibody - C-terminal region (P100732_P050)
- The freshwater snail is both ecologically and economically significant, exhibiting notable sexual dimorphism in growth and nutritional traits that underscore the importance of breeding of monosex stocks. However, the genetic basis of sex determination remains unclear. Herein, genome-wide association studies (GWASs) combined with transcriptomic analysis were conducted to identify sex-linked markers and candidate genes for this species. GWAS generated 571 significantly sex-associated SNPs and 1853 InDels, corresponding to 44 candidate genes. Multiple significant SNP peaks were detected on chromosomes 1 and 2, with and as key candidate genes. A sex-linked InDel marker located within can distinguish males and females cost-effectively. Genotype analysis of the sex-associated loci revealed that most females were homozygous while males were heterozygous, suggesting that has a primarily XX/XY sex determination system. Comparative gonadal transcriptome analyses identified 2996 female-biased and 4281 male-biased genes. Among them, , , and may be critical in male sex differentiation, while , , and may be important in female sex differentiation. Integration of GWAS and transcriptomic data highlighted four pronounced sex-associated candidate genes, including , , and . These results provide a valuable foundation for elucidating the genetic mechanisms underlying sex determination and for the development of monosex stocks in . - Source: PubMed
Publication date: 2026/03/14
Gao YajunWen YanhongYi ShaokuiLin YongPeng JinxiaPan XianhuiZhou Xiaoyun - Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders. SoxE proteins play critical roles during the development of multiple tissues in vertebrate embryos, including the neural crest, inner ear, cartilages, and glia cells of diverse origins, heart, gonads, and gastrointestinal tract. Because they recognize the same DNA sequence, possess conserved functional domains, and have overlapping expression profiles, SoxE proteins act partly redundantly in many contexts. However, Sox8, Sox9, and Sox10 also have many unique and tissue-specific functions. In particular, Sox9 plays an essential role in chondrogenesis, whereas Sox10 is a central regulator of pigment and glia cells. The highly context-specific regulation of different sets of target genes by SoxE factors is due to their ability to interact and cooperate with many other proteins including other transcription factors, cofactors, and enzymes, which modulate their regulatory activity. The activity of SoxE proteins is also frequently altered in a context-dependent fashion by post-translational modifications such as phosphorylation, acetylation, and SUMOylation. - Source: PubMed
Publication date: 2026/03/25
Lawrence MerinSchlosser Gerhard - The neural crest is a vertebrate stem cell population with broad developmental potential. While a gene regulatory network describing establishment of these cells has been generated, much remains to be learned about the dynamics of this process. Here, we use fluorescent in situ hybridization chain reaction to quantify the spatiotemporal dynamics of neural crest formation in Xenopus. We find that the initial onset of neural crest genes is broad and partially overlapping, with distinct anterior-posterior and medio-lateral biases. A shared neural crest domain emerges, but some genes retain relative expression differences that persist into migratory stages, producing stream-specific gene expression patterns. These differences correlate with dynamic expression of the neural plate border factors pax3 and zic1. Correlating relative intensities of pax3 and zic1 with the presence or absence of nascent neural crest transcripts predicts that these factors can differentially regulate snai2 and sox8, which we confirm experimentally. Strikingly, later stages display an inverse correlation between neural crest and neural plate border factors, suggesting that pax3 and zic1 initially promote neural crest gene activation but are downregulated as neural crest identity emerges. - Source: PubMed
Publication date: 2026/02/20
Montequin AndrewLaBonne Carole - Although androgen receptor (AR)-targeted therapies have shown notable clinical efficacy in prostate cancer (PCa), the emergence of drug resistance remains a critical factor driving the clinical prognosis in castration-resistant prostate cancer (CRPC). Aberrant tumor lipid metabolism not only fulfills the energetic and biosynthetic requirements of rapidly proliferating cancer cells but also contributes to the development of therapeutic resistance. - Source: PubMed
Publication date: 2026/02/10
Liu SongsongZhang DingyongJiang ChaoChen XinJin LiangXin ShiyongSun Xianchao - The mechanisms of metastasis and invasion in pancreatic cancer are promoted by the interaction between KRAS mutations and the transforming growth factor-β (TGF-β) pathway. However, the molecular mechanisms linking these pathways remain unclear. Downstream genes of KRAS pathway were identified by RNA sequencing in Panc-1 and MIA-PaCa2 cells. The function of the identified SOX8 was analyzed by using migration assays, western blotting of epithelial-mesenchymal transition (EMT) markers, and chemotherapy sensitivity. The correlation between SOX8 and TGF-β signaling was examined under recombinant TGF-β or TGF-β inhibitor treatment. SOX8 expression was also analyzed in resected specimens. SOX8 expression suppressed by KRAS knockdown, identifying it as a downstream regulated gene. SOX8 knockdown inhibited TGF-β signaling, reduced cell migration, altered EMT marker expression, and enhanced chemotherapy sensitivity. Furthermore, SOX8 knockdown activated the AKT/mTOR pathway, which was reversed by TGF-β inhibition. Clinically, high SOX8 expression correlated with poor prognosis. In conclusions, SOX8 functions as a molecular hub linking KRAS and TGF-β pathways, promoting epithelial-mesenchymal transition (EMT), invasive capacity, and chemotherapy resistance. This novel KRAS-SOX8-TGF-β axis plays the important role in invasion and metastasis of pancreatic cancer, suggesting SOX8 as a useful prognostic biomarker and therapeutic target. - Source: PubMed
Publication date: 2026/01/15
Chiba NaokazuKojima HirotakaSuda RyotaNakagawa MasashiOchiai ShigetoGunji TakahiroSano ToruTabuchi SatoshiIshizaki TetsuoKawachi Shigeyuki