TMF1 antibody - middle region (P100705_P050)
- Known as:
- TMF1 (anti-) - middle region (P100705_P050)
- Catalog number:
- p100705_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- TMF1 antibody - middle region (P100705_P050)
Related genes to: TMF1 antibody - middle region (P100705_P050)
- Gene:
- TMF1 NIH gene
- Name:
- TATA element modulatory factor 1
- Previous symbol:
- -
- Synonyms:
- ARA160, TMF
- Chromosome:
- 3p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-25
- Date modifiied:
- 2014-11-19
Related products to: TMF1 antibody - middle region (P100705_P050)
Related articles to: TMF1 antibody - middle region (P100705_P050)
- Canonical splicing variants (±2) contribute significantly to genetic disorders, yet the clinical significance of non-canonical splicing variants (NCSVs) that occur outside of canonical splicing sites remains unknown in male infertility. A comprehensive evaluation of reported studies on hereditary male infertility revealed that the 2,404 pathogenic variants contained 120 canonical splicing variants and 32 NCSVs. Among the remaining 2,252 variants, the splicing variant analytical strategy identified 17 novel NCSVs that disrupt normal mRNA splicing from previously classified missense variants. This expands the contribution of NCSVs by 53.13% (17/32), with NCSVs accounting for 28.99% (49/169) of all the splicing variants. Moreover, thirteen positively validated NCSVs are identified in 12 of 718 idiopathic male infertility patients with negative results by conventional genetic analysis. The first pathogenic variant in the TATA element modulatory factor 1 (TMF1: c.2859+4A>G) results in TMF1 exon 14 skipping and decreased progressive sperm motility and morphological abnormalities in a patient with male infertility. Tmf1 NCSV knock-in mice recapitulated human phenotype, showing significantly decreased sperm count, motility, ultrastructural head defects, and subfertility. This study provides the first comprehensive landscape of NCSVs in male infertility, suggesting that NCSVs may constitute a hidden etiological factor for male infertility. - Source: PubMed
Publication date: 2025/10/30
Li KuokuoChen YugeTang DongdongSheng YuyingHan XuGeng HaoZhang NaDuan ZongliuWang GuanxiongGao YangGuo RuiHua RongDing ZhimingXu ChuanShen QunshanYu ZhenSong BingLv MingrongXu YupingWu HuanWu JiCao YunxiaHe Xiaojin - The global incidence of diabetic foot ulcers (DFUs) has increased in parallel with the global incidence of diabetes mellitus, leading to a range of pathophysiologic conditions and a poor prognosis. ENTPD1, also known as CD39, is an extracellular nucleotidase associated with immunogenic cell death (ICD), but its role in DFUs remains unclear. Through single-cell RNA sequencing, we obtain the genetic, functional, trajectory, and communication differences between DFUs and healthy subjects. Then, we selected vascular endothelial cells (Vasendo) for further re-clustering to identify DFU-healing-promoted ENTPD1+ Vasendo and related ligand-receptor pairs in cell communication. The study demonstrated that ICD level and ENTPD1 expression were strongly correlated with DFUs, exhibiting greater enrichment in the Healing DFUs group than the Non-healing group. The Vasendo in the Healing group were enriched in the healing of DFUs and exhibited complex cellular communication. Re-clustering of Vasendo further identified the ENTPD1+ subtype. The trajectory and cell communication analysis further confirmed the healing-promoting effects of ENTPD1+ Vasendo, with inhibited ACKR1 receptor and MIF ligand when communicating with macrophages. Finally, expression quantitative trait loci (eQTL) Mendelian randomization and bulk sequencing validation data confirmed that upregulated expression of ANKIB1 and ANP32E with downregulated expression of SLC30A7 and TMF1 genes in DFUs Vasendo increased the risk of secondary diabetic peripheral artery disease (DPAD). Our study demonstrated the molecular mechanisms underlying DFUs healing and secondary DPAD occurrence, providing potential therapeutic targets for DFUs and DPAD therapy. - Source: PubMed
Zhang HeaoLi YichuanZhou ChuchaoFeng HetingLiu YilingShao ShiyingWu Yiping - Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by vascular remodeling and involves Endothelial-to-Mesenchymal transition (EndMT) in pulmonary artery endothelial cells (PAECs). EndMT is a complex cell differentiation process, mainly showing the detachment of endothelial cell migration and reducing endothelial cell characteristics to varying degrees, acquiring mesenchymal cell characteristics. In addition, numerous studies have reported that eIF3a over expression plays an important role in the occurrence and development of fibrotic diseases, cancer, and degenerative lesions, however, the mechanisms of eIF3a affecting the dysfunction of pulmonary arterial endothelial cells remains largely unknown. Therefore, we aimed to demonstrate the underlying mechanisms of eIF3a-knockdown inhibiting EndMT by regulating TGFβ1/SMAD signal pathway in PAH. - Source: PubMed
Publication date: 2025/05/09
Jiao QiuhongXu XiufengXu LongwuWang YuyingPang ShulanHao JieLiu XiaohongZhao YudanQi WanpengQin LiminHuang TaoLi JingtianWang Tao - Perovskite solar cells (PSCs) have recently achieved over 26 % power conversion efficiency, challenging the dominance of silicon-based alternatives. This progress is significantly driven by innovations in hole transport materials (HTMs), which notably influence the efficiency and stability of PSCs. However, conventional organic HTMs like Spiro-OMeTAD and PTAA, although highly efficient, suffer from thermal degradation, moisture ingress, and high cost. This study explores the potential of iminodibenzyl, a moiety known for its strong electron-donating capabilities in pharmaceutical applications, as a novel HTM. A series of fluorene-based derivatives incorporating iminodibenzyl (TMF-2 and TDF-2) and diphenylamine (TMF-1 and TDF-1) units were synthesized and characterized. The new HTMs demonstrated commendable optical, electrochemical, and thermal properties, as well as enhanced photostability. Among them, TDF-2 achieved a power conversion efficiency (PCE) of 19.38 %, the highest of the new materials. Although these efficiencies are slightly lower than the benchmark PTAA (20.20 %), the study underscores the potential of iminodibenzyl to enhance photostability and increase HOMO levels, making it a promising candidate for future HTM development in PSCs. - Source: PubMed
Publication date: 2025/01/28
Caicedo-Reina MauricioRocha-Ortiz Juan SWu JianchangBornschlegl Andreas JLeon SalvadorBarabash AnastasiaDario Perea JoseWang YunuoArango-Marín VanessaOrtiz AlejandroLüer LarryHauch Jens AInsuasty BraulioBrabec Christoph J - This study presents the phase analysis, microstructural characteristics, and mechanical property evaluation of the as-cast and quenched Ti-15Mo-xFe alloys with high iron content ranging from 4 to 12 weight percent. All the four alloys were produced in a vacuum-arc melting furnace. Heat treatment in the form of solution treatment was performed in a muffle furnace at a temperature of 1100 °C, with 1-h holding time and the samples were rapidly quenched in ice-brine. X-ray diffractometer (XRD) was used to analyses the phases present in each alloy whereas the optical microscope (OM) was employed to track the microstructural evolution and percentage porosity. The mechanical properties of the alloys were evaluated using a tensile test and compression test method while the micro-Vickers hardness measurements were conducted to evaluate hardness of the alloys. The XRD patterns of as-cast showed peaks belonging to the β and α″ phases and intermetallic B2 TiFe phases. The as quenched XRD peaks illustrated β phase only and Fe·Ti·O phases. The as-cast OM micrographs revealed equiaxed β grains, substructures, dendritic structure, and pores forming around the grain boundaries. The quenched OM showed only β equiaxed grains with pores throughout the grain boundaries. The tensile properties such as ultimate tensile strength (UTS) and elastic modulus (E) of as-cast TMF0 were 264 MPa and 79 GPa respectively and these properties changed upon quenching to 411 MPa and 66 GPa respectively. The elastic modulus of TMF1 in as-cast condition was 74 GPa. The UTS and E of TMF1, TMF2, and TMF3 in as-cast and quenched conditions were not recorded due to the fragility of the samples that failed prior to yielding any useful data. The compressive strength in as-cast and in quenched condition decreased with an increase in Fe content. The micro-Vickers hardness in as-cast and quenched conditions showed a similar trend with hardness increasing slightly upon quenching for TMF0, TMF1, and TMF3 alloys but slightly decreased in the case of TMF2. The fracture surfaces of all the as-cast and quenched alloys were comprised of ductile and brittle fracture. - Source: PubMed
Publication date: 2024/05/07
Moshokoa NthabisengMakhatha ElizabethRaganya LeratoMakoana WashingtonChauke HasaniDiale RamogohloPhasha Maje