RFX1 antibody - C-terminal region (P100690_P050)
- Known as:
- RFX1 (anti-) - C-terminal region (P100690_P050)
- Catalog number:
- p100690_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- RFX1 antibody - C-terminal region (P100690_P050)
Related genes to: RFX1 antibody - C-terminal region (P100690_P050)
- Gene:
- RFX1 NIH gene
- Name:
- regulatory factor X1
- Previous symbol:
- -
- Synonyms:
- EF-C
- Chromosome:
- 19p13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-06
- Date modifiied:
- 2017-05-23
Related products to: RFX1 antibody - C-terminal region (P100690_P050)
Related articles to: RFX1 antibody - C-terminal region (P100690_P050)
- Black Americans face a high burden of cardiovascular disease (CVD), with more than 60% of Black adult women affected. However, sex-specific molecular mechanisms underlying poor cardiovascular health (CVH) in this population remain largely unknown. In this study, we examined sex-specific transcriptomics signatures associated with CVH among Black adult men and women. - Source: PubMed
Publication date: 2026/01/19
Blankson Harriet NaDelmer CeciliaVerma RashiGuven EmineRooney KimberlyPearson AndreaBaltrus PeterQuyumi Arshed APemu PriscillaJordan I KingHerman TaylorMeller RobertSearles Charles D - - Source: PubMed
Publication date: 2026/01/28
Mo JinhuaZhang DongdongCai Ming - Hofbauer cells (HBCs) are fetal macrophages located in the placenta that contribute to antimicrobial defense, angiogenesis, tissue remodeling, and metabolic processes within the chorionic villi. Although their roles in placental biology are increasingly recognized, the mechanisms that regulate HBC identity and function are not yet fully defined. This study aimed to define the core transcriptomic and epigenomic features of HBCs in term placentas and to examine their capacity for transcriptional responsiveness and phenotypic variation. Using chromatin accessibility profiling and bulk RNA-seq, we found that HBCs exhibit a unique gene expression and chromatin accessibility profile compared with other fetal and adult macrophages. We identified a coordinated transcriptional network involving nuclear receptors (NRs) NR4A1-3, the glucocorticoid receptor, and RFX family members (RFX1, RFX2, RFX5) that appears to shape HBC identity, particularly through pathways linked to lipid metabolism and angiogenesis. Although exploratory in nature, in vitro stimulation studies showed that HBCs exhibited increased transcriptional activity in response to combined IL-4 and rosiglitazone treatment, including induction of the lipid transporter CD36. Mass cytometry analysis revealed surface markers indicative of both immature and mature macrophage states. These results together indicate that HBCs are a distinct and diverse population of macrophages with a specialized, adaptable regulatory program in the human placenta. - Source: PubMed
Publication date: 2025/12/23
Baráth Benjámin RBojcsuk DóraBene KrisztianCaballero-Sánchez NoemíCseh Tímeade Freitas João CrTzerpos PetrosToth MartaTang ZhonghuaGuller SethKrasznai Zoárd TiborNeuperger PatríciaSzebeni Gabor JNagy GergelyDeli TamásNagy Laszlo - The plastic role of regulatory factor X1 (RFX1) in colon cancer progression and its impact on the tumor microenvironment remain poorly understood. The study aimed to clarify the molecular and clinical role of RFX1 in colon cancer. - Source: PubMed
Publication date: 2025/11/27
Dai ZhujiangGe XiaoyongTang WenboLiu Chen-YingLiu YunWang Zhongchuan - Cerebral ischemia reperfusion (CIR) is a condition of brain, which is occurred due to insufficient supply of blood. Isofraxidin is a naturally occurring coumarin derivative which showed the strong anti-inflammatory and antioxidant effect in various disease animal models. Its neuroprotective effects against ischemia/reperfusion (I/R)-mediated injuries, however, have not been investigated. The current study was to scrutinize the neuroprotective effect of Isofraxidin against the CIR in rats. - Source: PubMed
Su LongHu XiaofangKumar AnkitYang Li