ENaC Gamma Antibody (OASE00462)
- Known as:
- ENaC Gamma Antibody (OASE00462)
- Catalog number:
- oase00462
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ENaC Gamma Antibody (OASE00462)
Related genes to: ENaC Gamma Antibody (OASE00462)
- Gene:
- SCNN1A NIH gene
- Name:
- sodium channel epithelial 1 alpha subunit
- Previous symbol:
- SCNN1
- Synonyms:
- ENaCalpha
- Chromosome:
- 12p13
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-12
- Date modifiied:
- 2018-03-02
- Gene:
- SCNN1B NIH gene
- Name:
- sodium channel epithelial 1 beta subunit
- Previous symbol:
- -
- Synonyms:
- ENaCbeta
- Chromosome:
- 16p12.2-p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-20
- Date modifiied:
- 2018-03-02
- Gene:
- SCNN1D NIH gene
- Name:
- sodium channel epithelial 1 delta subunit
- Previous symbol:
- -
- Synonyms:
- ENaCdelta, dNaCh
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-16
- Date modifiied:
- 2016-10-05
- Gene:
- SCNN1G NIH gene
- Name:
- sodium channel epithelial 1 gamma subunit
- Previous symbol:
- -
- Synonyms:
- ENaCgamma, SCNEG
- Chromosome:
- 16p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-10
- Date modifiied:
- 2018-03-02
Related products to: ENaC Gamma Antibody (OASE00462)
Related articles to: ENaC Gamma Antibody (OASE00462)
- The epithelial sodium channel (ENaC) plays a key role in osmoregulation in tetrapod vertebrates and is a candidate receptor for salt taste sensation. There are four ENaC subunits (α, β, γ, δ) which form αβγ- or δβγ ENaCs. While αβγ-ENaC is a 'maintenance protein' controlling sodium and potassium homeostasis, δβγ-ENaC might represent a 'stress protein' monitoring high sodium concentrations. The δ-subunit emerged with water-to-land transition of tetrapod vertebrate ancestors. We investigated the evolutionary path of ENaC-coding genes in Cetartiodactyla, a group comprising even-toed ungulates and the cetaceans (whales/dolphins) which transitioned from terrestrial to marine environments in the Eocene. The genes (α-ENaC), (β-ENaC) and (γ-ENaC) are intact in all 22 investigated cetartiodactylan families. While (δ-ENaC) is intact in terrestrial Artiodactyla, it is a pseudogene in 12 cetacean families. A fusion of exons 11 and 12 under preservation of the open reading frame was observed in the Antilopinae, representing a new feature of this clade. Transcripts of and were present in kidney and lung tissues of Bottlenose dolphins, highlighting αβγ-ENaC's role as a maintenance protein. Consistent with loss, Bottlenose dolphins and Beluga whales did not show behavioural differences to stimuli with or without sodium in seawater-equivalent concentrations. These data suggest a function of δ-ENaC as a sodium sensing protein which might have become obsolete in cetaceans after the migration to high-salinity marine environments. Consistently, there is reduced selection pressure or pseudogenisation of in other marine mammals, including sirenians, pinnipeds and sea otter. - Source: PubMed
Publication date: 2024/11/19
Zahnow FynnJäger ChiaraMohamed YassminVogelhuber GianlucaMay FabianCiocan Alexandra MariaManieri AriannaMaxeiner StephanKrasteva-Christ GabrielaCobain Matthew R DPodsiadlowski LarsCrespo-Picazo José LuisGarcía-Párraga DanielAlthaus Mike - The epithelial Na channel (ENaC) is intrinsically linked to fluid volume homeostasis and blood pressure. Specific rare mutations in , , and , genes encoding the α, β, and γ subunits of ENaC, respectively, are associated with extreme blood pressure phenotypes. No associations between blood pressure and , which encodes the δ subunit of ENaC, have been reported. A small number of sequence variants in ENaC subunits have been reported to affect functional transport in vitro or blood pressure. The effects of the vast majority of rare and low-frequency ENaC variants on blood pressure are not known. - Source: PubMed
Publication date: 2022/10/04
Blobner Brandon MKirabo AnnetKashlan Ossama BSheng ShaohuArnett Donna KBecker Lewis CBoerwinkle EricCarlson Jenna CGao YanGibbs Richard AHe JiangIrvin Marguerite RKardia Sharon L RKelly Tanika NKooperberg CharlesMcGarvey Stephen TMenon Vipin KMontasser May ENaseri TakeRedline SusanReiner Alexander PReupena Muagututi'a SSmith Jennifer ASun XiaoVaidya DhananjayViaud-Martinez Karine AWeeks Daniel EYanek Lisa RZhu Xiaofeng Minster Ryan LKleyman Thomas R - The epithelial sodium channel (ENaC) is composed of three homologous subunits and allows the flow of Na(+) ions across high resistance epithelia, maintaining body salt and water homeostasis. ENaC dependent reabsorption of Na(+) in the kidney tubules regulates extracellular fluid (ECF) volume and blood pressure by modulating osmolarity. In multi-ciliated cells, ENaC is located in cilia and plays an essential role in the regulation of epithelial surface liquid volume necessary for cilial transport of mucus and gametes in the respiratory and reproductive tracts respectively. The subunits that form ENaC (named as alpha, beta, gamma and delta, encoded by genes SCNN1A, SCNN1B, SCNN1G, and SCNN1D) are members of the ENaC/Degenerin superfamily. The earliest appearance of ENaC orthologs is in the genomes of the most ancient vertebrate taxon, Cyclostomata (jawless vertebrates) including lampreys, followed by earliest representatives of Gnathostomata (jawed vertebrates) including cartilaginous sharks. Among Euteleostomi (bony vertebrates), Actinopterygii (ray finned-fishes) branch has lost ENaC genes. Yet, most animals in the Sarcopterygii (lobe-finned fish) branch including Tetrapoda, amphibians and amniotes (lizards, crocodiles, birds, and mammals), have four ENaC paralogs. We compared the sequences of ENaC orthologs from 20 species and established criteria for the identification of ENaC orthologs and paralogs, and their distinction from other members of the ENaC/Degenerin superfamily, especially ASIC family. Differences between ENaCs and ASICs are summarized in view of their physiological functions and tissue distributions. Structural motifs that are conserved throughout vertebrate ENaCs are highlighted. We also present a comparative overview of the genotype-phenotype relationships in inherited diseases associated with ENaC mutations, including multisystem pseudohypoaldosteronism (PHA1B), Liddle syndrome, cystic fibrosis-like disease and essential hypertension. - Source: PubMed
Publication date: 2016/01/07
Hanukoglu IsraelHanukoglu Aaron - To focus on the asthmatic pathogenesis and clinical manifestations related to epithelial sodium channel (ENaC)/chlorine ion channel. - Source: PubMed
Wang WenJi Hong-Long - Eggshell quality is important for the poultry industry. During eggshell formation a mass of inorganic minerals is deposited. The Sodium Channel (SCNN1) gene family plays an essential role in cation transportation. The objective of this study was to investigate the pattern of expression of members of the SCNN1 gene family, their variation and their effects on eggshell quality. - Source: PubMed
Publication date: 2013/09/24
Fan Yan-FengHou Zhuo-ChengYi Guo-QiangXu Gui-YunYang Ning