HO-1 (Rat) Antibody (OASE00435)
- Known as:
- HO-1 (Rat) Antibody (OASE00435)
- Catalog number:
- oase00435
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- HO-1 (Rat) Antibody (OASE00435)
Related genes to: HO-1 (Rat) Antibody (OASE00435)
- Gene:
- SARNP NIH gene
- Name:
- SAP domain containing ribonucleoprotein
- Previous symbol:
- -
- Synonyms:
- THO1, Hcc-1, CIP29
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2009-04-22
- Date modifiied:
- 2016-11-10
Related products to: HO-1 (Rat) Antibody (OASE00435)
Related articles to: HO-1 (Rat) Antibody (OASE00435)
- Radioresistance remains the primary cause of radiotherapy failure in non-small cell lung cancer (NSCLC). This study investigated the regulatory role of HMOX1-mediated ferroptosis in NSCLC radiosensitivity. Radioresistant cell models (H1650R/H1975R) were established through fractionated irradiation of parental H1650/H1975 cells. Transcriptomic analysis by RNA sequencing revealed significant HMOX1 suppression in resistant cells. Functional validation demonstrated that HMOX1 overexpression enhanced radiation sensitivity via ferroptosis induction, whereas HMOX1 knockdown aggravated radioresistance. Mechanistic investigations identified USP7 as a key deubiquitinating enzyme that stabilizes KEAP1 through K48-linked polyubiquitin chain cleavage, thereby promoting NRF2 ubiquitination and suppressing HMOX1 transcription. Pharmacological inhibition using KI696 blocked KEAP1-NRF2 interaction, restoring HMOX1 expression. Notably, the USP7 inhibitor GNE-6640 destabilized KEAP1, upregulated NRF2/HMOX1 axis activity, and triggered ferroptosis in resistant cells. In vivo studies confirmed that GNE-6640 synergized with radiotherapy to suppress tumor growth and pulmonary metastasis in xenograft and NSG mouse models, as monitored by bioluminescence imaging. These findings establish the USP7-KEAP1-NRF2-HMOX1 axis as a critical determinant of radioresistance, demonstrating that targeted USP7 inhibition with GNE-6640 reactivates ferroptosis and restores radiosensitivity. This dual-mechanistic approach provides a novel therapeutic strategy to overcome treatment resistance in NSCLC. - Source: PubMed
Publication date: 2026/04/23
Tang JianweiXu LeiGong ZetianChen Liang - This study aims to screen potential targets of Curcumin (Cur) in Myocardial ischaemia-reperfusion injury (MIRI) using network pharmacology and molecular docking, and to experimentally validate whether Cur mitigates MIRI by modulating the NLRP3 inflammasome and pyroptosis via the Nrf2/HO-1 pathway. - Source: PubMed
Yao LinglingQin JunShen JunZhang FushengLiu Jinghua - To investigate how Srolo Bzhtang (SBT), a classical Tibetan medicine formula, improves oxidative stress and ultimately alleviates pulmonary fibrosis in rats through the Nrf2/HO-1 and PI3K/AKT/mTOR pathways. - Source: PubMed
DU JinyangBaimalazong Dejibaizhen Basangdeji Bianbaciren Ye Bengui - To explore the medication patterns and mechanisms of action of Shaofu Zhuyu decoction (, SFZYD) in inhibiting ferroptosis through the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1)/glutathione peroxidase 4 (GPX4) pathway to improve diabetes mellitus-induced erectile dysfunction (DMED). - Source: PubMed
Zhuo WangYinhui MaoYueyue ZangShuangyan H EJuntao SunZhitao WeiMingxing WangYong Yang - This study investigated the proteomic characteristics and biological functions of hypoxic exosomes derived from hypoxia-preconditioned feline adipose-derived mesenchymal stem cells (ADMSCs), aiming to reveal the remodeling effect of hypoxic preconditioning on the protein composition of exosomes derived from feline ADMSCs and its potential applications. CoCl was used to mimic a hypoxic environment for ADMSCs, and exosomes were isolated by differential ultracentrifugation. The physical properties of the exosomes were characterized by transmission electron microscopy, nanoparticle tracking analysis, and Western blotting. Proteomic analysis revealed that hypoxic preconditioning significantly altered the exosomal proteomic profile, identifying 120 differentially expressed proteins (116 upregulated and 4 downregulated). Bioinformatic analysis indicated significant enrichment of key pathways including the hypoxia-inducible factor-1 (HIF-1) signaling pathway, adenosine monophosphate-activated protein kinase (AMPK) signaling pathway, autophagy, and proteasome function. Gene ontology (GO) functional annotation demonstrated significant enrichment of biological processes such as metabolic processes, cell cycle regulation, and signal transduction in the hypoxia-preconditioned group. Kyoto encyclopedia of genes and genomes (KEGG) analysis further suggested potential biological functions through the regulation of pathways including the cell cycle and renin-angiotensin system. Notably, hypoxia-responsive proteins such as HMOX1 and TFRC were upregulated, while pathways related to the renin-angiotensin system were suppressed. This study systematically elucidates, for the first time, the remodeling effect of hypoxic preconditioning on the proteome of exosomes derived from feline ADMSCs, providing new molecular insights into exosome-mediated intercellular communication. - Source: PubMed
Lou JiaoChen HaiyanFeng EnhuiLi WeinaChen PanlongChen YunlongFan XinyiXu JingmeiFang PingWang YanLu DezhangZhang Shiqiang