HSPB2 (MKBP) Antibody (OASE00422)
- Known as:
- HSPB2 (MKBP) Antibody (OASE00422)
- Catalog number:
- oase00422
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- HSPB2 (MKBP) Antibody (OASE00422)
Related genes to: HSPB2 (MKBP) Antibody (OASE00422)
- Gene:
- HSPB2 NIH gene
- Name:
- heat shock protein family B (small) member 2
- Previous symbol:
- -
- Synonyms:
- Hs.78846, MKBP
- Chromosome:
- 11q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-12-23
- Date modifiied:
- 2015-11-19
Related products to: HSPB2 (MKBP) Antibody (OASE00422)
Related articles to: HSPB2 (MKBP) Antibody (OASE00422)
- infection is closely associated with the tumor microenvironment (TME) in gastric cancer (GC), yet its underlying mechanism is elusive. Hence, it is imperative to explore the microenvironment and drug resistance arising from to enhance therapeutic strategies for GC. - Source: PubMed
Publication date: 2025/05/30
Tan JinshuiWu ZhengxinLiu YuankunWang WeiQin WenjuanPan GuangchaoXiong YuboMa JingsongZhao JiabaoZhou HuiwenLiu ZhengJinLu HaijieZhuo HuiqinHong Xuehui - Metabolic disorder and endothelial dysfunction (ED) are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of Cardiovascular disease (CVD). The pathophysiology remains incompletely understood. - Source: PubMed
Publication date: 2025/05/15
Sun QiXie LongchuanAn HeChen WeiYang QirongWang PengTang YijunPeng Chunyan - Alzheimer's disease (AD) has been largely prevalent among the older population. With the increasing incidence of cancer over the years, scientists have explored the relationship between these two conditions which were formerly associated with aging. Interestingly, an inverse relationship between cancer and AD has been observed in large cohort studies which has garnered substantial interest. While this inverse relationship presents a fascinating scientific puzzle, there is limited data on the molecular mechanisms that govern this phenomenon. This study aims to investigate the fundamental molecular mechanisms driving the inverse association between AD and three common cancers: breast, prostate, and colorectal cancers. Gene expression data for AD were obtained from the Gene Expression Omnibus (GEO) repository, specifically the GSE122063 data set. Differentially expressed genes (DEGs) between AD and nondemented controls were identified using the GEO2R tool. Genes associated with breast, prostate, and colorectal cancer were obtained from the Genecards database. Shared genes between cancers and AD-upregulated genes were identified using the Venny 2.1 tool. The UALCAN analysis portal was used to evaluate the mRNA expression of shared genes in cancer types. The DAVID tool, ShinyGO and SRplotter tools were used for functional enrichment analyses and gene ontology annotations. We found 20 genes upregulated in AD but significantly downregulated in breast cancer, 11 significantly downregulated in prostate cancer and 5 genes downregulated in colon cancer. Key genes were involved in pathways related to muscle structure, DNA repair, protein stability, and gene expression regulation. Three (3) of these genes, , , and , were downregulated in all three cancers and may play an important role in reduced risk of cancer development while upregulated in AD. This study serves as a foundational effort to delve deeper into the molecular connections between AD and various cancer types, using the identified genes as a promising starting point for future experimental investigations to fully elucidate the mechanisms involved in the inverse interaction and protection of AD patients against cancer development. - Source: PubMed
Publication date: 2025/04/24
Anyomi Bright KwakuFosu KwadwoLamptey Emmanuel LanteAgegnehu Solomon BaynesagneQuarshie Jude TettehKampo SylvanusWei Jianshe - In the central nervous system, glioma stands as the predominant primary brain tumor. Heat shock proteins exerted a critical influence on tumor progression and tumor immune microenvironment. However, research on heat shock proteins in glioma remained ambiguous. We analyzed data from the CPTAC, TCGA, and GTEx databases, identifying seven heat shock protein genes critical to glioma prognosis. Subsequently, through Lasso regression, a model based on heat shock protein genes (DNAJC7, DNAJC12, HSPB2, HSP90B1, HSPA5) was constructed. And the risk score showed a positive correlation to the immune score. Further investigation into immune cells revealed that HSPA5 and HSP90B1 were expressed at higher levels in glioma and significantly linked to M2 macrophage infiltration. Considering the limited research on HSP90B1 in glioma, we further revealed that HSP90B1 might have a connection with two crucial signaling pathways within tumors: PI3K/AKT and Wnt/β-catenin. Given that lactate could promote the M2 polarization of macrophages, we further found that HSP90B1 could enhance the transcription of glycolysis-related genes, including LDHA. Overall, our study demonstrated that heat shock protein genes were significantly linked to glioma patient prognosis. Additionally, we observed that HSP90B1 had a significant relationship with M2 macrophage infiltration and potentially regulated LDHA level in glioma. - Source: PubMed
Publication date: 2025/04/15
Xu JiachengGuo YuduoNing WeihaiWang JunChen YujiaLiu DeshanYang JingjingSong YongmeiZhang Hongwei - Cisplatin (CP) has been used as an effective chemotherapy drug for different types of cancers. Despite its therapeutic benefits, the clinical utility of CP is often hindered by adverse effects, notably acute kidney injury (AKI), which restricts its widespread application. Dihydromyricetin (DHM) is a flavonoid acquired from , exhibiting a range of pharmacological activities. The major objective of this research was to examine the possible molecular mechanism involved in CP-induced AKI and the protective function of DHM. - Source: PubMed
Publication date: 2025/04/14
Xu ZhemingZhang MinjingZhang XueHan HuirongYe WeifengChen ZhenjieLv ZhisuLiu YangLiu ZhengyeGong JianguangZhu BinZhou SuhanZhu RunzhiTao ChangZhang GenshengYan Xiang