Hsp90 (P. Falciparum) Antibody (OASE00418)
- Known as:
- Hsp90 (P. Falciparum) Antibody (OASE00418)
- Catalog number:
- oase00418
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- Hsp90 (. Falciparum) Antibody (OASE00418)
Related genes to: Hsp90 (P. Falciparum) Antibody (OASE00418)
- Gene:
- HSP90AA1 NIH gene
- Name:
- heat shock protein 90 alpha family class A member 1
- Previous symbol:
- HSPC1, HSPCA
- Synonyms:
- Hsp89, Hsp90, FLJ31884, HSP90N
- Chromosome:
- 14q32.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-27
- Date modifiied:
- 2016-10-11
Related products to: Hsp90 (P. Falciparum) Antibody (OASE00418)
Related articles to: Hsp90 (P. Falciparum) Antibody (OASE00418)
- Tributyl citrate (TBC), a widely used substitute for phthalate plasticizers, has shown increasing environmental accumulation, raising concerns about its potential human health risks. However, its toxicological effects, particularly regarding gastrointestinal disease progression, remain largely unexplored. In this study, animal experiments first demonstrated that TBC aggravates colonic inflammation in a mouse model of microplastic-induced colitis. Computational toxicology analysis further predicted TBC to possess potential carcinogenic properties, suggesting its role in promoting colitis-associated carcinogenesis. Using integrated bioinformatics approaches, we combined network toxicology, molecular docking, and molecular dynamics simulations to identify the putative toxicological targets and molecular pathways involved in TBC-induced inflammation-to-cancer transition. A total of 299 TBC-related targets were identified from multilevel databases, and 13 core targets were highlighted through STRING and Cytoscape analyses, including AKT2, MAPK1, MAPK3, HSP90AA1, PIK3CD, BCL2, PIK3R1, PIK3CB, ESR1, CASP3, KRAS, and ERBB2. GO and KEGG enrichment analyses indicated that TBC may drive carcinogenic progression via pathways associated with oxidative stress and inflammatory responses. Molecular docking and dynamics simulations validated the stable interactions between TBC and key targets. To further confirm TBC's role in colitis-associated tumorigenesis, we employed an AOM/DSS-induced colorectal cancer mouse model and found that TBC significantly exacerbated both intestinal inflammation and tumor formation. Transcriptomic analysis further validated the enrichment of ROS-mediated chemical carcinogenesis pathways and revealed that intestinal barrier disruption may also be a critical contributor to TBC-mediated cancer progression. Collectively, this study provides a theoretical basis for understanding the molecular mechanisms by which TBC aggravates inflammation-associated colorectal cancer, and offers a framework for risk assessment and regulatory strategies addressing plasticizer exposure in digestive health. - Source: PubMed
Publication date: 2025/10/08
Chen HaosongCheng YixianZhou YaoFu RuiJia JianguangZhang ShuyuanChen JunjieCao HaikunZhang PengGeng QilongGu JinghuaChen BoHan WenxiuXiong MaomingLi TingCao Guodong - Current therapy for Parkinson's disease (PD), a neurodegenerative disorder that progresses over time marked by protein aggregation, dopaminergic neuronal death and oxidative stress, only provides symptomatic alleviation. By using an integrative computational strategy that combines molecular dynamics simulations, molecular docking and network pharmacology, this study sought for the investigation of the neuroprotective potential of methoxylated flavonoids (MFs). Drug-likeness and ADMET profiling of ten MFs revealed favorable pharmacokinetics, including good oral bioavailability and low predicted toxicity. Network pharmacology identified 172 putative targets, of which 118 overlapped with PD-associated genes, highlighting the multi-targeted nature of these compounds. Protein-protein interaction analysis revealed important hub proteins like HSP90AA1, MMP9, GSK-3β and AKT1 involved in neurodegeneration, oxidative stress regulation, and apoptotic signaling. Analysis of KEGG and GO pathway enrichment revealed significant modulation of the signaling pathway PI3K-Akt and the cellular elements necessary for neuronal survival and repair. Molecular docking revealed high-affinity interactions of Eupatilin and Norwogonin with key PD targets, particularly HSP90AA1 and MMP9. Molecular dynamics simulations confirmed the Eupatilin-HSP90AA1 complex's stability over a 100 ns period, indicating stable interactions and minimal conformational fluctuations. These findings suggest that methoxylated flavonoids possess multi-target therapeutic potential against PD, contributing to broader goals in public health and mental health by modulating interconnected neuroprotective pathways. However, as the results are predictive in nature, confirming their translational value requires experimental confirmation through and research. Study highlights Eupatilin as a potential lead substance for additional pharmacological research aimed at disease modification in Parkinson's disease. - Source: PubMed
Publication date: 2026/04/01
Ashok ChetanJeyabalan SrikanthPavadai ParasuramanM VigneshS Devaraja Dravida PandiyanMohan DurgaSugumar RevathiSugumar RamyaJabaris Sugin LalSubramaniyan VetriselvanWong Ling ShingSekar Mahendran - Bisphenol A (BPA), an industrial compound widely used in plastics and food packaging, has been implicated in the development of various diseases. This study aims to elucidate the molecular toxicity mechanisms of BPA in hepatocellular carcinoma (HCC), providing a theoretical foundation for the prevention and treatment of HCC. - Source: PubMed
Publication date: 2026/04/02
Zhang YananWu YangWu ChujiangHe YuxinZhai YujieZhou ZihanZhang JiucongZheng Xiaofeng - Pyrethroid insecticides are widely used globally, but their potential nephrotoxicity has gained increasing attention. Although previous studies suggest pyrethroids may induce acute kidney injury (AKI), the underlying mechanisms remain unclear. This study employed a network toxicology approach to elucidate the molecular mechanisms of pyrethroid-induced AKI. Eight commonly used pyrethroids were analyzed individually. A total of 3203 AKI-related genes were retrieved from public databases, and intersection analysis identified 157-196 common targets for each pyrethroid. Protein-protein interaction (PPI) network integration further identified 18 shared hub targets across the eight pyrethroids, among which 15 were further supported by GEO validation in AKI samples. Notably, 7 targets - SRC, CASP3, ESR1, CCND1, MMP9, BCL2, and HSP90AA1-were consistently shared across all compounds and were therefore considered as core targets. Enrichment analyses indicated that these targets were mainly involved in oxidative stress-, inflammation- and apoptosis-related processes. GEO validation further suggested that these alterations were particularly prominent in renal tubular cells and endothelial cells. Molecular docking supported potential interactions between pyrethroids and the core targets. The findings suggested that pyrethroid-induced AKI may involve processes related to oxidative stress, inflammation, and apoptosis, accompanied by impaired repair responses, ultimately disrupting the balance between injury and regeneration in renal tubular epithelial cells. - Source: PubMed
Publication date: 2026/04/19
Xue XuhangWu YuqingSheng PeiGeng LianyiTang YuxinZhu XinlongWang XufangAn XiaofeiGao Kun - This study aims to explore the mechanism of Cangfu Daotan decoction (CFDT) in treating polycystic ovary syndrome, insulin resistance, obesity, and infertility with homotherapy for heteropathy based on network pharmacology methods. The active components and corresponding protein targets of CFDT were identified through a systematic screening of the Traditional Chinese Medicine Systems Pharmacology database, while disease-associated targets were retrieved from OMIM, Genecards, and DrugBank databases. Common targets were derived from Venn analysis and utilized to construct a protein-protein interaction network via STRING and Cytoscape 3.8.0, through which core targets were identified. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway assessment were subsequently performed on these key targets using R 4.1.1. Molecular docking simulations were finally conducted to evaluate binding interactions between pivotal bioactive compounds and the identified core targets. A total of 151 active ingredients, 238 drug targets and 2722 disease targets were screened. Among them, quercetin, kaempferol, luteolin, and wogonin are the main active ingredients. TP53, AKT1, STAT3, IL6, and HSP90AA1 are the core therapeutic targets. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis screened 178 pathways, including lipid and atherosclerosis and advanced glycation end product (AGE)-receptor for AGE signal pathways in diabetes complications. Gene Ontology functional enrichment analysis yielded 2423 Gene Ontology entries, mainly involving biological processes including heterologous stimulation, lipopolysaccharide response, oxidative stress, glandular development, as well as cellular composition including membrane rafts and vesicles, and molecular functions including DNA binding transcription factor binding and cytokine activity. Molecular docking shows that the active ingredients of CFDT have good affinity for core disease targets. Molecular docking confirmed strong binding affinity between key compounds and targets. It is preliminarily revealed that the main active ingredients of CFDT are quercetin, kaempferol, luteolin and wogonin, which may improve polycystic ovary syndrome, insulin resistance, obesity, and infertility by regulating lipid and atherosclerosis and AGE-receptor for AGE signal pathways in diabetes complications. - Source: PubMed
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