KIR2DL1 Antibody (OASA03029)
- Known as:
- KIR2DL1 Antibody (OASA03029)
- Catalog number:
- oasa03029
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- KIR2DL1 Antibody (OASA03029)
Related genes to: KIR2DL1 Antibody (OASA03029)
- Gene:
- KIR2DL1 NIH gene
- Name:
- killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
- Previous symbol:
- -
- Synonyms:
- cl-42, nkat1, 47.11, p58.1, CD158A
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-14
- Date modifiied:
- 2016-11-09
Related products to: KIR2DL1 Antibody (OASA03029)
Related articles to: KIR2DL1 Antibody (OASA03029)
- Host immune responses that can target and eliminate HIV-1 reservoir cells during suppressive antiretroviral therapy are poorly understood. Here, analyzing over 6,000 proviral DNA amplicons from 104 individuals on long-term antiretroviral therapy, we found that carriers of HLA-C2 allotypes, which promote NK cell education via interactions with KIR2DL1, exhibited lower frequencies of intact proviruses. No protective effects of HLA-C2 alleles were observed during untreated infection, suggesting a selective vulnerability of reservoir cells to NK-cell-mediated immune activity under antiretroviral therapy. Supporting this, frequencies of KIR2DL1 NK cells, particularly those coexpressing the activating HLA-E receptor NKG2C, were inversely correlated with frequencies of intact proviruses. Moreover, viral protein U variants that strongly downregulate HLA-C, increasing a missing-self response by KIR2DL1NK cells, were associated with smaller reservoirs in carriers of HLA-C2. Infected cells surviving long-term displayed elevated HLA-C expression, consistent with in vivo selection for resistance to KIR2DL1NK-cell-mediated immune clearance. Immune activity of KIR2DL1 NK cells against viral reservoir cells was enhanced by NKG2C-HLA-E interactions, as sequence variants in HLA-E-restricted HIV-1 epitopes reduced NKG2C-dependent NK cell activation and were associated with higher frequencies of intact proviruses. These findings underscore the critical influence of host and viral genetic variation on reservoir persistence and highlight opportunities for leveraging innate immunity in HIV cure strategies. - Source: PubMed
Publication date: 2026/09/01
Tan Toong SengSun WeiWeiGao CeViard MathiasWalters Lucy CLancien MelanieYuki YukoVan Tram NCasquero CarlosGuo XuanHoh RebeccaHaas David WMichael NelsonKirk Gregory DYendewa GeorgeGandhi Rajesh TKassaye Seble GTien Phyllis CWalker Bruce DPeluso Michael JJacobson Jeffrey MDeeks Steven GCarrington MaryYu Xu GLichterfeld Mathias - Trauma induces significant physiological changes that can lead to substantial morbidity and mortality. Many of these changes alter immune homeostasis, which underlies seemingly disparate syndromes of systemic inflammation and global immune suppression, the causes of which remain unclear. Innate immune cells play a key role in the response to trauma, and recent studies have suggested that natural killer (NK) cells are dynamically responsive to mild versus severe systemic trauma. - Source: PubMed
Publication date: 2026/08/10
Bazzi NaghamStempora LindaHensman HannahQuinones Patricia MartinezNegron Isabel RodriguezKrynychka KaterynaGelbard Rondi BGrey Scott FSchobel Seth AElster EricFernandez-Moure JosephKirk Allan D - Reproductive failures, including recurrent implantation failures (RIF), recurrent pregnancy losses (RPL), and adverse pregnancy outcomes (APO), are increasingly linked to immunological factors at the maternalfetal interface. Killer immunoglobulin-like receptors (KIRs) on natural killer (NK) cells play a key role in regulating maternal immune responses to trophoblast HLA-C antigens. - Source: PubMed
Kovarova TerezaBitoova MartinaLuxova StepankaKoudova MonikaKoucky MichalCerna Karin - The killer-cell immunoglobulin-like receptors (KIR) are a family of activating and inhibitory Class I human leukocyte antigen (HLA-I) binding receptors expressed on natural killer (NK) cells and subsets of T cells. The KIR detect HLA-I molecules in a peptide-dependent manner, with some KIR displaying exquisite peptide specificity. Studying peptide recognition by KIR often uses TAP-deficient cell lines expressing single HLA-I alleles, which are heterogenous and time consuming to generate. Here, we established an alternative approach using peptide-exchange technologies hitherto developed for studying T cell recognition of HLA-I. - Source: PubMed
Publication date: 2026/05/25
Murali Tanusya MLi BeiningHoos EmeryCollinson LucyLong Eric ODushek OmerElliott TimSim Malcolm J W - Immune dysregulation and cognitive deficits are increasingly recognized in adolescent major depressive disorder (MDD), yet their interrelationship remains unclear. This study aimed to investigate peripheral immune-inflammatory alterations and natural killer (NK) cell phenotypes, and explore their association with cognitive function in adolescent MDD. - Source: PubMed
Publication date: 2026/05/16
Wang JiahuiHou LingzhiLi CaiLiu YitongXu YanHe YangYang LeiWang LiLiu QidongCheng JunZhang YanyanMa YunmiaoXu HaiweiLi Hong