Human IL11 ELISA Kit
- Known as:
- Human IL11 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- orb50806
- Product Quantity:
- 96 well
- Category:
- Peptides
- Supplier:
- Biorb
- Gene target:
- Human IL11 ELISA Kit
Related genes to: Human IL11 ELISA Kit
- Gene:
- IL11 NIH gene
- Name:
- interleukin 11
- Previous symbol:
- -
- Synonyms:
- IL-11, AGIF
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2016-10-11
Related products to: Human IL11 ELISA Kit
Related articles to: Human IL11 ELISA Kit
- The establishment of endometrial receptivity is a fundamental prerequisite for successful embryo implantation and the maintenance of pregnancy. Decidualization, a critical process in the maturation of endometrial receptivity, is intimately linked to implantation success. The precise molecular regulation of both processes is essential for normal pregnancy outcomes. Within the endometrium, the activation of the transcription factor signal transducer and activator of transcription 3 (STAT3) exhibits strict temporal and spatial specificity. Its phosphorylation levels peak during the mid-secretory phase, aligning perfectly with the window of implantation, thereby establishing STAT3 as a primary indicator of endometrial receptivity. Activated by crucial cytokines-including leukemia inhibitory factor (LIF), interleukin (IL)-11, and epidermal growth factor (EGF)-STAT3 operates through the Janus kinase (JAK)/STAT signaling pathway. It regulates the functional maturation, adhesive capacity, and polarity remodeling of endometrial epithelial cells, creating an optimal environment for blastocyst attachment. Concurrently, STAT3 acts as a central regulator of decidualization by directly driving the proliferation and differentiation of endometrial stromal cells (ESCs) while maintaining the stability of the decidual microenvironment. Furthermore, STAT3 modulates the local immune milieu by orchestrating immune cell polarization and cytokine networks, providing essential immunological support. Conversely, dysregulation of the STAT3 signaling pathway leads to impaired endometrial receptivity and defective decidualization, contributing to adverse reproductive outcomes such as implantation failure and miscarriage. This review comprehensively highlights the pivotal regulatory functions of the STAT3 pathway in endometrial receptivity and decidualization, establishing a robust theoretical foundation for future basic research and targeted clinical strategies. - Source: PubMed
Publication date: 2026/09/22
Zhao HongZou ZongyuanYang Yihua - The immunosuppressive tumor microenvironment (TME) represents a major barrier to effective hepatocellular carcinoma (HCC) therapy. While interleukin-11 (IL-11) has been implicated in cancer progression, its immunomodulatory functions and underlying mechanisms in HCC remain poorly understood. - Source: PubMed
Publication date: 2026/09/17
Gao YangYao XijuanHuang XingWang LianWang YongZhu GuangyuWang ZhenLi LuGuo JinheLu Jian - Excessive conjunctival fibroblast proliferation is a major factor in postoperative scarring following ophthalmic surgery. While Rebamipide is clinically used for dry eye and has anti-inflammatory effects, its direct impact on the transcriptomic profiles and inflammatory signaling of conjunctival fibroblasts remains unclear. We aimed to elucidate the gene expression pathways by which Rebamipide modulates the inflammatory and fibrotic responses of Primary Human Conjunctival Fibroblasts (HCFCs). - Source: PubMed
Publication date: 2026/09/09
Kinari GenTagami MizukiKira YukimiHaruna YusukeMisawa NorihikoMizukami YoichiHonda Shigeru - In this study, we demonstrate that during diabetic wound healing, interleukin-11 (IL-11) promotes the M1 polarization of macrophages, which subsequently triggers fibroblast senescence through the enhanced release of pro-inflammatory cytokines IL-1β and IL-6. Notably, Rhoifolin (Rho) effectively inhibits IL-11-induced M1 polarization, alleviates the secretion of IL-1β and IL-6, and concurrently promotes the release of choline, thereby mitigating fibroblast senescence. Based on these mechanistic findings, we constructed a targeted delivery system by loading Rho into mesoporous silica nanoparticles and coating them with macrophage membranes (M-Rho). The M-Rho were then incorporated into a poly(L-lysine)-grafted hyperbranched poly(amidoamine) (PLL-g-HPA) hydrogel to fabricate microneedles (Gel@M-Rho MN). This integrated system enables macrophage targeting, controlled drug release, favorable mechanical properties, and excellent biocompatibility. Moreover, the system exhibits potent reactive oxygen species (ROS)-scavenging activity and effectively inhibits the growth of Escherichia coli and Staphylococcus aureus. In vivo animal studies confirmed that Gel@M-Rho MN significantly promotes M2 macrophage polarization, suppresses fibroblast senescence, and accelerates wound closure, angiogenesis, and collagen deposition. Collectively, this strategy, which modulates macrophage-fibroblast crosstalk, offers a multi-mechanistic synergistic therapeutic approach for diabetic wounds, holding substantial potential for clinical translation. - Source: PubMed
Publication date: 2026/09/16
Liao JiewenGan LinLu LiOuyang LizhiXiong YuanAl-Smadi FawwazDai GuandongShahbazi Mohammad-AliMi BobinLiu MengfeiLiu Guohui - Pararamosis, or pararama-associated phalangeal periarthritis, is a neglected tropical disease affecting rubber tappers in the Amazon, caused by contact with the urticating bristles of the caterpillar. This condition leads to chronic synovitis and progressive cartilage degradation, key features shared with other osteoarticular conditions such as osteoarthritis. - Source: PubMed
Publication date: 2026/08/25
Pohl Paula CZapotoski Luiza N KSardinha Luiz RVillas-Boas Isadora MPidde GiselleTambourgi Denise V