Human IL20RA ELISA Kit
- Known as:
- Human IL20RA Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- orb55228
- Product Quantity:
- 5 plates
- Category:
- Peptides
- Supplier:
- Biorb
- Gene target:
- Human IL20RA ELISA Kit
Related genes to: Human IL20RA ELISA Kit
- Gene:
- IL20RA NIH gene
- Name:
- interleukin 20 receptor subunit alpha
- Previous symbol:
- -
- Synonyms:
- ZCYTOR7, IL-20R1
- Chromosome:
- 6q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-23
- Date modifiied:
- 2015-12-11
Related products to: Human IL20RA ELISA Kit
Related articles to: Human IL20RA ELISA Kit
- Degenerative lumbar spine disorders (DLSD), including intervertebral disc disorders (IDD), degenerative spondylolisthesis, and lumbar spinal stenosis (LSS), are major contributors to low back pain and disability. Associations among gut microbiota (GM), inflammatory proteins, and DLSD have been demonstrated in prior studies. Yet, two key questions persist: whether specific circulating inflammatory proteins (IPs) mediate this association, and whether such mediation is shared across different diseases. - Source: PubMed
Publication date: 2026/06/03
Lou YongfuMa DaoyiGan QingquanXu XianyueXiao YimingWang JunzhuoLi ZhibingZhang TaoQi LeiFeng Shiqing - Circular RNAs (circRNAs) are increasingly recognized as key post-transcriptional regulators. However, their functions within the avian hypothalamic-pituitary-ovarian (HPO) axis remain poorly understood. To investigate potential associations of circRNAs with breed differentiation and reproductive traits, we constructed cross-tissue circRNA profiles through whole-transcriptome sequencing of the HPO axis in Zi and Xianghai flying geese. A total of 90, 80, and 90 DE-circRNAs were identified in the hypothalamus, ovary, and pituitary, respectively, corresponding to 248 non-redundant DE-circRNA IDs across the three tissues. Functional enrichment analysis revealed that their host genes were significantly enriched in reproduction-related signaling pathways, including cAMP, PI3K-Akt, FoxO, JAK-STAT, GnRH, and VEGF signaling pathways. GO terms related to reproduction, reproductive process, and growth were significantly enriched, with protein interaction analysis identifying CYP19A1, FSHR, BMP15, and ESR1 as central network hubs. Furthermore, through systematic integration of cross-tissue circRNA, miRNA, and mRNA expression profiles and a series of analytical steps including correlation-based filtering and hypergeometric testing, we thereby constructed a cross-tissue ceRNA network. Several functional modules were identified, including novel_circ_000988-miR-1451-y/miR-216-x/miR-735-x-IL20RA, novel_circ_019479-miR-1338-y/miR-1388-y-GLRA2, and novel_circ_010669-miR-143-z-Med27. Our results indicate that circRNAs may be associated with a cross-tissue neuroendocrine-ovarian regulatory network through putative ceRNA-associated interactions, providing candidate molecular insights into reproductive trait variation in geese. - Source: PubMed
Xie LinhongZhao ZhonglongZhang YonghongZhan KunYuan ManSun HaoZhang XiaojunYang SibaoYang Yuwei - Type 2 diabetes (T2D) and its complications are linked to cognitive decline over time, accompanied by cortical abnormalities. The causality between T2D and cortical modifications, however, remains elusive. - Source: PubMed
Huang HongHuang HanyuGong YanlinZhou TengtengLiang YundanWang Yichao - Previous studies have found that circulating inflammatory proteins may play an essential role in the occurrence and development of neuropathic pain. However, the majority of existing evidence is derived from observational studies, which are prone to confounding factors and reverse causality, and the inflammatory profiles associated with different types of neuropathic pain remain poorly understood. Consequently, more robust methodologies are urgently required to elucidate the causal relationships between these variables. Therefore, a bidirectional Mendelian randomization analysis was performed to assess the causal relationship between inflammatory proteins and neuropathic pain, specifically focusing on neuralgia and neuritis, including glossopharyngeal neuralgia, phantom limb syndrome with pain,small fiber neuropathy, and unspecified neuralgia. - Source: PubMed
Publication date: 2026/02/17
Zhong JiajunLi HuanminHuang ChongboZhang PengfeiPang XiaoyuLuo ZimengLi Chunguang - The Republic of Korea is the global leading producer of olive flounder (Paralichthys olivaceus), accounting for approximately 49% of national aquaculture production. Acute low-temperature stress poses a major challenge to this industry, causing substantial economic losses through impaired growth, increased mortality, and compromised immune function. This study aimed to identify genetic markers associated with acute low-temperature stress tolerance using a genome-wide association study (GWAS) and determine optimal genomic prediction parameters. A total of 576 healthy olive flounders (average weight 419.57 ± 9.56 g) were subjected to acute low-temperature stress at 9 °C for 20 min. Serum cortisol levels were measured and caudal fin samples were collected from 384 individuals for genomic DNA isolation. Genotyping using a 70 K single-nucleotide polymorphism (SNP) chip yielded 57,638 high-quality SNPs from 375 individuals, which were analyzed using a linear mixed model. Eighteen putative SNPs exhibiting suggestive significance level (p < 1 × 10) were identified on chromosomes 8, 20, and 21; however, none surpassed the Bonferroni-corrected genome-wide significance threshold (p < 8.6 × 10). These suggestive associations, therefore, require validation in independent populations. Among them, SNPs AX-419197258 and AX-419200963 explained 3.44% and 3.25% of the phenotypic variance, respectively. Functional annotation indicated that putative candidate genes, including gbe1, serta, lpgat1, and il20ra, are involved in key biological and immune-related pathways. Genomic prediction analyses demonstrated that the random forest model achieved the highest accuracy for predicting serum cortisol levels. Moreover, GWAS-based marker selection outperformed random marker selection, with approximately 1000 markers identified as optimal for reliable prediction. Collectively, these findings provide insights into the genetic architecture of low-temperature stress tolerance in olive flounder and support the application of genomic approaches in selective breeding programs to enhance resilience and sustainability in aquaculture. - Source: PubMed
Publication date: 2026/02/05
Hanchapola H A C RKim GaeunOmeka W K MGong PoLiyanage D SUdayantha H M VKodagoda Yasara KavindiDilshan M A HRodrigo D C GGanepola G A N PiyumikaJo YuhwanLee JeongyongMassault CecileJerry Dean RLee JihunKim JeongeunLee Jehee