LMO4 Antibody (OAAF06580)
- Known as:
- LMO4 Antibody (OAAF06580)
- Catalog number:
- oaaf06580
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- LMO4 Antibody (OAAF06580)
Related genes to: LMO4 Antibody (OAAF06580)
- Gene:
- LMO4 NIH gene
- Name:
- LIM domain only 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-30
- Date modifiied:
- 2014-11-19
Related products to: LMO4 Antibody (OAAF06580)
Related articles to: LMO4 Antibody (OAAF06580)
- Understanding the molecular mechanisms underpinning convergent traits can provide insight into the predictability of the evolutionary process. The thylacine, an extinct marsupial carnivore, has been long known to have a very similar craniofacial morphology to that of eutherian canids, despite having diverged approximately 160 million years ago. Using a massively parallel reporter assay (MPRA), we test the regulatory potential of a set of previously identified highly conserved craniofacial enhancers that showed convergent sequence acceleration in thylacine and wolf (TWARs). We compare orthologous sequences from six different taxa, including outgroup taxa with nonconvergent craniofacial phenotypes (Tasmanian devil and giant panda) and ancestral reconstructions for marsupial and placental carnivores (Dasyuromorphia and Carnivora). Dense 10 bp tiling allowed us to thoroughly examine features associated with activity, including percentage GC content and transcription factor binding motifs turnover. We identify marked conservation of levels and patterns of regulatory activity across all six taxa, as well as multiple cases of differentially active TWARs within each clade, with both thylacine and wolf driving functional divergence. However, evidence of convergent divergence relevant to craniofacial biology is limited to a TWAR with reduced activity in both the thylacine and wolf near the developmental gene Ultimately our findings suggest that shared gene regulatory potential is not a feature of these convergently accelerated regions in the thylacine and wolf. - Source: PubMed
Publication date: 2026/09/23
Shukla NavyaCook Laura EmilyVespasiani Davide MariaPask Andrew JGallego Romero Irene - To develop and validate a machine learning(ML)-based integrated predictive model combining genetic, epigenetic, and clinical factors for predicting leflunomide (LEF) treatment response in rheumatoid arthritis (RA) patients. - Source: PubMed
Publication date: 2026/06/24
Chen MengLiu HainaJin LeiFeng XinDai BingbingWang FangWang QiaoChen YulanYi ManJia BowenDong KangyiZhang JintaoFan ZhijunLi JiahuiZhao FengJia YuanyuanWang JianpengLiu MiaoXu JiayiFu Lingyu - Ménière disease (MD) is a chronic inner ear disorder characterized by recurrent vertigo, fluctuating sensorineural hearing loss, and tinnitus, but its etiology remains poorly understood. We performed a genome-wide meta-analysis of 8,969 MD case subjects and 1,962,542 control subjects across five biobanks, identifying five independent genome-wide significant loci and estimating an observed-scale SNP heritability of 7% (SE 0.8%), indicating a modest but significant contribution of common genetic variation to MD risk. The genome-wide significant signals comprise two independent variants at EYA4, two at EYA1, and one near CYP26A1, with odds ratios between 1.1 and 1.25. Associations at two additional loci, LMO4 and ALDH1A2, fell just below the genome-wide significance threshold (5 × 10 Publication date: 2026/06/16
Shi ZhuozhengMandla RaviLi JingjingLi XinzheZhang Zixuan EleanorChen SixingLapinska SandraFlynn-Carroll Alexander OPasaniuc BogdanEpstein Douglas JMathieson Iain - Genome-wide DNA methylation patterns in across host environments and developmental stages have not been systematically characterized. We performed whole-genome bisulfite sequencing (WGBS) on worms recovered from permissive C57BL/6 mice and non-permissive Sprague-Dawley rats at 24 and 42 days post infection (dpi). . exhibited globally low methylation levels (2.10%-2.86%). Hierarchical clustering indicated that sampling time explained the largest methylome differences, followed by sex- and host-associated variation. Worms from permissive hosts showed a more pronounced methylation decrease from 24 to 42 dpi, whereas worms from non-permissive hosts displayed attenuated changes alongside stunted growth. Sex-associated patterns shifted with maturation. Differentially methylated genes were enriched for phosphorylation-related terms and included , , , and . We identified 242 host/sex hotspot differentially methylated genes (e.g., ) enriched for transmembrane ion transport. Together, these results delineate host- and sex-associated signatures and nominate candidates for functional validation. - Source: PubMed
Publication date: 2026/04/17
Peng WeixuanCheng ShuangshuangWang YuepengLiu QiXu ShuhuaWang JipengHu WeiLu Yan - Bacterial diarrheal diseases continue to constitute a major burden on global public health, particularly within pediatric populations in low-resource settings. While clinically unified by the symptomology of diarrhea, the primary causative agents; Enterotoxigenic Escherichia coli (ETEC), Shigella species, Salmonella enterica, and Clostridioides difficile employ fundamentally distinct molecular strategies to subvert intestinal homeostasis. This review presents a comparative analysis of these ecosystem engineers, proposing that their pathogenicity is defined by their unique management of the host-microbiota metabolic and signaling conflict. We advance beyond the traditional host-pathogen dyad to explore a mechanistic triangle, integrating recent findings that the microbiota acts as a dynamic third player imposing colonization resistance via secondary bile acids and nutrient competition (proline), or conversely, providing metabolic fuel (formate, tetrathionate) for pathogen expansion. We synthesize advanced molecular insights from including the energetics of the Shigella T3SS sorting platform (Spa47); the multilayered "effector-immunity arms race" involving the Shigella effectors OspC1 and OspD3 in manipulating necroptosis; novel Salmonella T3SS-2 targets such as LMO4 and SteA-mediated ER contact sites; and the receptor diversity of C. difficile TcdB variants. Finally, we map these mechanisms to next-generation therapeutic vulnerabilities, highlighting the transition from broad-spectrum antibiotics to precision bacteriophage biocontrol (LPEK22, LPST94) and AI-discovered lysins (DeepLysin) as the future of intervention. - Source: PubMed
Publication date: 2026/04/20
Bayode Michael TosinOlawale Oluwatoyosi EzekielOlusola-Makinde Olubukola Olayemi