CDH23 Antibody (OAAF02851)
- Known as:
- CDH23 Antibody (OAAF02851)
- Catalog number:
- oaaf02851
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CDH23 Antibody (OAAF02851)
Related genes to: CDH23 Antibody (OAAF02851)
- Gene:
- CDH23 NIH gene
- Name:
- cadherin related 23
- Previous symbol:
- DFNB12, USH1D
- Synonyms:
- CDHR23
- Chromosome:
- 10q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-10-19
- Date modifiied:
- 2016-06-03
- Gene:
- DCHS2 NIH gene
- Name:
- dachsous cadherin-related 2
- Previous symbol:
- CDH27, PCDH23
- Synonyms:
- CDHJ, FLJ20047, PCDHJ, CDHR7
- Chromosome:
- 4q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-09-11
- Date modifiied:
- 2016-10-05
Related products to: CDH23 Antibody (OAAF02851)
Related articles to: CDH23 Antibody (OAAF02851)
- BACKGROUND: Chinese indigenous goat breeds exhibit rich genetic diversity and a long history of domestication, endowing these native populations with superior traits in environmental adaptation, forage utilization, and disease resistance. The identification of selection signatures through comparative genomic analysis could facilitate the understanding of breed differentiation and enables the discovery of functionally important genes. Using whole-genome sequencing data (23.87× Average coverage), we assessed genetic variation, population stratification, runs of homozygosity (ROH), and selection signatures in two Chinese goat breeds: Inner Mongolia cashmere goats (IMCGs, n = 200) and Zhongwei goats (ZWGs, n = 200). RESULTS: The results showed that the two goat breeds exhibited distinct separation in the phylogenetic tree and the Principal component analysis (PCA) and the IMCG population exhibited a faster LD decay rate. A total of 11,484 and 7240 ROH fragments were detected in ZWGs and IMCGs respectively by homozygosity analysis of all chromosomes. Subsequently, the investigation of regions of homozygosity (ROH) was performed utilizing the PLINK software. In ZWGs and IMCGs, there were 5 and 14 genomic regions with high frequency of ROH island (ROHi) respectively, leading to the identification of 77 genes, containing 10 shared genes. Taking Fst (screening for population differentiation sites), π-Ratio (reflecting genetic diversity differences), and XP-CLR (detecting cross-population selection sweeps) as the core methods, cross-screening for strong selection signal regions; Tajima’s D is used to verify whether the candidate regions deviate from neutral evolution (to exclude genetic drift interference), and finally results to obtain 10 (ROHi) and 38 (Fst, π-Ratio, XP-CLR) shared candidate genes. Among these candidate genes are related to carcass and muscle development (CTNNA1, BIRC6, SIL1, BMPER, CACNA2D1, DGKB, MED13), fat deposition (BMPER, MAP3K3, PDGFD, FREBF2), growth and body size (DCHS2, GALNTL6, PDGFD, SHROOM3), cashmere (NBEA, TGFBR3, GALNTL6), reproduction (BRIC6, CDH23) and environmental adaptation (NBEA, CNGB3) of goats. Among them, PDGFD and TGFBR3 genes showed highly significant differentiation and haplotype patterns between the two groups. These results provide suggestive evidence that PDGFD and TGFBR3 genes may play an important role in the differentiation of goat body size and cashmere characteristics, which is worth further investigation. CONCLUSION: In summary, we conducted a genome-wide exploration of goats from two regions in China. Our analysis of the population structure, genetic diversity and selection signature of these two groups revealed several selection regions and candidate genes that could influence goat important traits and characteristics through various selection signal analysis methods. The findings of this study provide a basis for further conservation and utilization of goat resources and offer valuable materials for genetic improvement of goats. - Source: PubMed
Publication date: 2026/01/20
Han MingxuanRong YoujunWang XinleAo XiaofangShang FangzhengWang ZhiyingSu RuiWang RuijunLiu YongbinZhang Yanjun - Impaired function of brain morphogenic genes is considered one of the predisposing factors for the manifestation of psychiatric and cognitive disorders, such as paranoid schizophrenia (SCZ) and major depressive disorder (MDD). Identification of such genes (genes of neurotrophic factors and guidance molecules among them) and their deleterious genetic variants serves as a key to diagnosis, prevention, and possibly treatment of such disorders. In this study, we have examined the prevalence of genomic variants in brain morphogenic genes in individuals with SCZ and MDD within a Russian population. - Source: PubMed
Publication date: 2024/04/18
Karagyaur MaximPrimak AlexandraBozov KirillSheleg DmitriyArbatsky MikhailDzhauari StalikIllarionova MariaSemina EkaterinaSamokhodskaya LarisaKlimovich PolinaVelichko ArkadiyDrach MikhailSotskaya EkaterinaPopov VladimirRubina KseniyaParfenenko MariiaMakus JuliaTsygankov BorisTkachuk VsevolodNeyfeld Elena