NCoR1 Antibody (OAAF01953)
- Known as:
- NCoR1 Antibody (OAAF01953)
- Catalog number:
- oaaf01953
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- NCoR1 Antibody (OAAF01953)
Related genes to: NCoR1 Antibody (OAAF01953)
- Gene:
- NCOR1 NIH gene
- Name:
- nuclear receptor corepressor 1
- Previous symbol:
- -
- Synonyms:
- N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216, PPP1R109
- Chromosome:
- 17p12-p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-17
- Date modifiied:
- 2018-02-13
Related products to: NCoR1 Antibody (OAAF01953)
Related articles to: NCoR1 Antibody (OAAF01953)
- Chromosomal instability (CIN), a hallmark of malignancy, remains poorly understood in clear cell renal cell carcinoma (ccRCC). Here, we identify spindle and kinetochore-associated protein 3 (SKA3) as a critical regulator of CIN in ccRCC. BAP1 loss-of-function mutations, prevalent in ccRCC, drive aberrant SKA3 overexpression. Mechanistically, BAP1 deubiquitinates nuclear receptor co-repressor 1 (NCOR1) to enhance its recruitment to the SKA3 promoter, thereby repressing SKA3 transcription. Additionally, BAP1-mediated histone H2AK119 deubiquitination at the TRIM25 promoter activates the expression of TRIM25, facilitating ubiquitin-proteasome-mediated degradation of SKA3. BAP1 deficiency disrupts both regulatory pathways, leading to aberrant accumulation of SKA3, which fuels CIN and correlates with metastasis progression and poor prognosis. In conclusion, our findings establish dysfunction of the BAP1-SKA3 axis as a molecular driver of CIN in ccRCC and suggest SKA3 as a potential therapeutic target for BAP1-mutant ccRCC. - Source: PubMed
Publication date: 2026/07/15
Wang YueyangLai ChongWang LinglingDeng JingwenTian ZhouLiang ZhiyongZhang Honghe - Ovarian senescence is the fundamental cause of reduced fertility in female animals,however, the molecular characteristics of ovarian ageing in sheep remain insufficiently defined. In this study, ovarian tissues were collected from 12 Qira Black sheep and assigned to group D (1-2 years, = 6) and group H (5-6 years, = 6) for LC-MS/MS-based proteomic profiling. A total of 458 differentially expressed proteins (DEPs) were identified between the two groups, including 211 upregulated and 247 downregulated proteins. Functional enrichment analyses indicated that these DEPs were mainly involved in cell-cycle regulation, oocyte maturation, amino acid metabolism, and inflammation-related signalling pathways, with the Rat Sarcoma(Ras) and Mitogen-Activated Protein Kinase Pathway(MAPK) signalling pathways showing particularly strong enrichment. Protein-protein interaction (PPI) network analysis revealed close interactions among Intraflagellar transport 80(IFT80), Insulin receptor(INSR), Angiopoietin-like 4(ANGPTL4), Receptor interacting serine/threonine kinase 3(RIPK3), Nuclear receptor corepressor 1(NCOR1), and Fms-Related Tyrosine Kinase 4(FLT4), with Insulin receptor(INSR) occupying a central hub position. Collectively, this study establishes a differential proteomic atlas of ovarian ageing in Qira Black sheep, highlights the potential importance of Rat Sarcoma(Ras) and Mitogen-Activated Protein Kinase Pathway(MAPK) signalling in this process, and identifies Insulin receptor(INSR) as a candidate target, thereby providing a theoretical basis for subsequent mechanistic studies and the development of molecular markers. - Source: PubMed
Publication date: 2026/06/30
Guo PeilinPei LinlinLiu NingjieWang WenhaoQiao AndiXu XinLiu Chunjie - Genomic complexity and small case numbers make statistically robust assessment of mutational patterns in osteosarcoma difficult. The authors analyzed a large cohort of targeted next-generation sequencing data from osteosarcoma cases from young patients submitted for clinical testing to Foundation Medicine. - Source: PubMed
Bousquet Hannah GKuang ZhengVega Lorena Lazo de laCeca EvelinaSchiantarelli JuliaHonecker JuliusHiemenz Matthew CForrest Suzanne JJaneway Katherine A - Hepatocellular carcinoma (HCC) remains a therapeutic challenge due to the limited efficacy of current systemic therapies. To identify potential therapeutic approaches, computational analysis of HCC datasets and drug screening were integrated, leading to the repurposing of hematological malignancy drug selinexor (an XPO1 inhibitor) for HCC treatment. Functional studies revealed that XPO1 inhibition triggers oxidative stress and cell cycle arrest in HCC cells through nuclear sequestration of NCOR1, disrupting redox homeostasis through FOXK1-dependent transcriptional activation of genes associated with reactive oxygen species (ROS). A genome-wide CRISPR-Cas9 screen further identified the KEAP1-NRF2 axis as a key determinant of sensitivity to XPO1 inhibition. Furthermore, high-throughput compound screening demonstrated that disulfiram, a clinically used aldehyde dehydrogenase inhibitor, synergizes with XPO1 inhibitor through exacerbation of ROS accumulation. Collectively, these findings demonstrate the therapeutic repurposing of selinexor for HCC while uncovering its mechanism of action, establishing a predictive biomarker, and proposing an immediately translatable combination therapy. - Source: PubMed
Publication date: 2026/07/07
Wang WeiZhang LinmengZuo QiaozhuMa XuhuiCao YingZhu LiliJi ShuyiQin WenxinWang HuiYuan ShengxianBernards RenéWang Cun - Lagopsis supina is a traditional Chinese medicinal herb used for activating blood circulation and nourishing the blood. This study aims to investigate the pro-angiogenic constituents of L. supina and their mechanisms of their action. 30 compounds derived from the active fraction LS-D (L. supina 60% ethanol-water extract) were screened, of which 15 showed angiogenesis-promoting activity, were screened in a PTK787-induced vascular injury zebrafish model. The active constituents were primarily phenolic acids and phenylpropanoids, among which compounds LS21 (vanillic acid) and LS22 (syringic acid) exhibited the most potent pro-angiogenic effects. These constituents (LS21 and LS22) were selected for further investigation of mechanisms of promoting angiogenesis. Transcriptomic analysis followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment revealed differentially expressed genes and predicted involved pathways. Molecular docking simulated interactions between compounds and key pathway proteins, and RT-qPCR validated gene expression patterns. Mechanistic studies integrating transcriptomics, molecular docking, and RT-qPCR revealed that both LS21 and LS22 downregulated immune-related cell adhesion molecules, while upregulating cdh5 and pecam1a. Additionally, LS21 specifically downregulated the signaling molecules smad2 and smad3a, and upregulated the transcriptional corepressors skila and ncor1. In contrast, LS22 downregulated extracellular matrix-related adhesion molecules and itga2b, while upregulating thbs1a and integrin itgb3b. In conclusion, the L. supina constituents LS21 and LS22 that are primarily phenolic acids and phenylpropanoids, exert their angiogenesis-promoting effects mainly via modulating cell adhesion and suppressing TGF-β signaling pathway. - Source: PubMed
Publication date: 2026/07/06
Yu JiahaoWang XiaoyiJia LiyanFu LuluHe JunweiZhang ShanshanHe QiuxiaLiu KechunLi XiaobinLi Na