FLNA Antibody (Phospho-Ser2152) (OAAF00047)
- Known as:
- FLNA Antibody (Phospho-Ser2152) (OAAF00047)
- Catalog number:
- oaaf00047
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- FLNA Antibody (Phospho-Ser2152) (OAAF00047)
Related genes to: FLNA Antibody (Phospho-Ser2152) (OAAF00047)
- Gene:
- FLNA NIH gene
- Name:
- filamin A
- Previous symbol:
- FLN1, FLN, OPD2, OPD1
- Synonyms:
- ABP-280
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1993-03-18
- Date modifiied:
- 2019-04-23
Related products to: FLNA Antibody (Phospho-Ser2152) (OAAF00047)
Related articles to: FLNA Antibody (Phospho-Ser2152) (OAAF00047)
- Pediatric wheezing diseases are linked to the risk of progression to persistent wheezing or asthma, particularly in cases with chronic airway inflammation and genetic predisposition. Early identification of high-risk children is crucial for timely intervention, yet the recovery phase of wheezing episodes, a transitional period, is often overlooked. - Source: PubMed
Publication date: 2026/08/24
Ben JianhuaWu LingyanTong LuyunJin Yi - Post-COVID-19 condition (PCC) with secondary adrenal insufficiency (SAI) involves multiorgan dysfunction, potentially linked to renin-angiotensin-aldosterone system dysregulation. The molecular basis of renin-associated pathology remains unclear. Here, PCC+SAI patients were stratified by upright renin into low- (<38.8 pg/mL) and high-renin (≥38.8 pg/mL) groups. Clinical, endocrine, and proteomic analyses were performed. We found that high-renin patients showed increased BMI, lipids, renin, and aldosterone, but reduced aldosterone-to-renin ratio. Proteomic annalysis identified 20 differentially expressed proteins (DEPs), including 17 upregulated and 3 downregulated proteins in Ren-H patients. Functional annotation revealed that 15 DEPs were immune-related (e.g., APOC4, APOE, C4BPA, CFAH, CFHR3, PF4V, PLF4), while FLNA and COF1 represented cytoskeletal proteins. These DEPs were primarily involved in immune response, complement and coagulation cascades, and MAPK signaling pathways. Correlation analyses indicated that upright renin was positively correlated with complement-related proteins and platelet-derived immune factors, while cytoskeletal proteins (FLNA, COF1) showed positive associations with serum Na+ levels. Additionally, white blood cell and platelet counts were positively correlated with the majority of DEPs. In conclusion, exploratory proteomic analyses suggest that elevated upright renin in PCC+SAI may be associated with immune dysregulation, complement activation, and cytoskeletal remodeling, offering novel insights into the endocrine-immune interactions driving postviral sequelae. - Source: PubMed
Bai GuirongXie XiaominJi WenruiHe YantingZhang LiLi HuanYang YazhiWu YawenPei SiqiLi LingPing Rui - Spontaneous coronary artery dissection (SCAD) is characterized by a separation of the coronary artery wall, causing myocardial infarction and sudden death. This study is one of the first to clarify the impact of pathological genetic variants in candidate SCAD-related genes on the histopathological and morphological properties of human SCAD lesions. - Source: PubMed
Publication date: 2026/09/01
Tanaka TakamasaKawakami RikaGaynor Brady JWilliams DesireeAugenstreich JacquesSakamoto AtsushiJinnouchi HiroyukiKawai KenjiKonishi TakaoShiraki TatsuyaSekimoto TeruoNakayama TakafumiFujiyoshi KazuhiroHamana TomoyoAdachi YusukeDiaz Keisha MedinaHong Charles CGrogan AlyssaMitchell Braxton DVirmani RenuFinn Aloke V - FLNA encodes filamin A, a ubiquitously expressed actin-binding cytoskeletal protein that cross-links actin filaments and links them to membrane-associated signaling complexes. Although FLNA has been implicated in T-cell signaling and regulatory T-cell development in murine models, its role in human immune-cell function remains incompletely understood. Here, we investigated the immunological phenotype associated with a novel hemizygous FLNA variant identified in a pediatric patient presenting with recurrent infections and inflammatory manifestations. Whole-exome sequencing revealed a hemizygous c.7405C>T (p.Pro2469Ser) variant in FLNA, which was confirmed by Sanger sequencing. Its potential impact on immune-cell function and cytoskeletal organization was evaluated using confocal microscopy, flow cytometry, and molecular assays. Patient-derived T cells showed impaired activation and proliferation following CD3/CD28 and IL-2 stimulation, accompanied by reduced CD25 and CD69 upregulation. CD4+ T cells also exhibited reduced IFN-γ, TNF-α, and IL-2 production after stimulation. Despite elevated basal phospho-STAT5 levels, IL-2-induced STAT5 phosphorylation and TCR-associated signaling responses, including pZAP70, pLCK, and p38 MAPK activation, were attenuated. Confocal imaging together with image-based quantification demonstrated altered cortical cytoskeletal organization in patient T cells despite preserved FLNA expression. In parallel, NK cells showed impaired activation responses and reduced cytotoxic activity under the assay conditions used. Increased apoptosis was observed in CD4⁺, CD8⁺, and NK-cell populations. Inflammatory cytokines were elevated in plasma and colonic tissue, whereas colonic ZO-1 and FLNA expression were reduced. Collectively, these findings indicate that the FLNA p.Pro2469Ser variant is associated with altered immune-cell signaling, disturbed cortical cytoskeletal organization, and immune dysregulation. This study expands the phenotypic spectrum linked to FLNA variants and supports a role for filamin A in human immune-cell regulation. - Source: PubMed
Publication date: 2026/08/31
Erdem ŞerifeKısaarslan Ayşenur PaçAcar Mustafa BurakDoğan Muhammet EnsarÇiçek Sümeyra ÖzdemirGaripcin PınarAyaz Güner ŞerifeÖzcan AlperHaskoloğlu ŞuleÇetin Benhur ŞirvanAltay DeryaKöse MehmetDaldaban Sarıca BuketBelkaya SerkanBaşaran Kemal ErdemDoğu Figenİkincioğulları Kamile AydanÜnal EkremEken Ahmet - Hepatocellular carcinoma (HCC) is characterized by frequent recurrence, therapeutic resistance, and marked metabolic adaptability. Disulfidptosis is a recently described form of regulated cell death associated with glucose deprivation and disulfide stress. This study aimed to identify disulfidptosis-related genes associated with HCC progression and to investigate the potential biological role of SLC5A6. - Source: PubMed
Publication date: 2026/08/14
Fu ChongFang ZejingZhang YanpingXu Wei