NEO1 antibody - center region (OAAB13233)
- Known as:
- NEO1 (anti-) - central region (OAAB13233)
- Catalog number:
- oaab13233
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- NEO1 antibody - center region (OAAB13233)
Related genes to: NEO1 antibody - center region (OAAB13233)
- Gene:
- NEO1 NIH gene
- Name:
- neogenin 1
- Previous symbol:
- -
- Synonyms:
- NGN, HsT17534, IGDCC2, NTN1R2
- Chromosome:
- 15q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-26
- Date modifiied:
- 2016-10-05
Related products to: NEO1 antibody - center region (OAAB13233)
Related articles to: NEO1 antibody - center region (OAAB13233)
- While a plethora of studies exist exploring the diverse components of MMD, a multifaceted approach is needed to target new therapeutic interventions and provide a holistic understanding of the genetic and inflammatory components of MMD etiology. - Source: PubMed
Publication date: 2026/05/25
Kashibhatla AnanthZotarelli-Filho Idiberto JoséSreenivasan SanjeevNanda AnilRoychowdhury SudiptaGupta Gaurav - Restoration of vascular structure and function is pivotal for neurological recovery following spinal cord injury (SCI), yet repairing the blood-spinal cord barrier (BSCB) remains a significant challenge. In this study, we demonstrate that exosomes (Exos) derived from endothelialized human umbilical cord mesenchymal stem cells (E‑UCMSCs) markedly enhance angiogenesis, improve vascular function, and promote neurological recovery. Human umbilical cord mesenchymal stem cells were induced to differentiate into endothelial‑like cells, and RNA‑sequencing revealed upregulation of genes associated with angiogenesis and vascular barrier integrity, alongside activation of relevant signaling pathways. In a co‑culture system, E‑UCMSC‑derived Exos significantly enhanced bEnd.3 cell migration and BSCB stability. To enable targeted delivery to neovasculature, Exos were engineered with RGD peptides (RGD‑E‑UCMSC‑Exos) via lentiviral modification. In vivo, these modified Exos preferentially localized to neovascular endothelial cells, promoted angiogenesis, reinforced BSCB integrity, and improved neurological outcomes in SCI mouse models. Proteomic profiling identified key angiogenic and barrier‑stabilizing factors carried by RGD‑E‑UCMSC‑Exos, including MMP2, FLT1, TIMP1, GAS6, CTHRC1, and NEO1, which likely mediate their therapeutic effects. Collectively, these findings provide novel mechanistic insights and establish a novel strong preclinical foundation for exosome‑based therapies in SCI. - Source: PubMed
Publication date: 2026/03/26
Liu QuanboZhang WentaoXue JingboLi XuelinTan JinghuaXu ZhunWang MingLi YunlongOuyang ZhihuaWang ChengYan YiguoJiang LiyuanXie Yong - Cerebral microbleeds (CMBs) are small vascular lesions detectable on MRI and are associated with increased stroke risk and cognitive decline. However, imaging-based diagnosis is limited by cost and accessibility. This study aimed to identify serum protein biomarkers for early CMB diagnosis and to elucidate molecular mechanisms underlying CMB subtypes. - Source: PubMed
Publication date: 2026/03/05
Yin Wu-MengHe Liu-ChangHan Guang-YiLi An-MingZhu Hang-HangCao YuanXue Xin-LiZhang LeiShi Chang-HeXu Yu-MingWang Yun-Chao - Astrocytes coordinate vascular homeostasis and tissue clearance in the brain, yet how these functions are mechanistically integrated remains unclear. Here, we identify neogenin (NEO1) as a cortex-specific astrocytic regulator that links angiogenesis with phagocytosis. Astrocyte-specific deletion of NEO1 in the mouse cortex, but not the hippocampus, leads to elevated HIF1/2α levels, increased expression of the angiogenic factor VEGFa, and reduced expression of the phagocytic receptor MEGF10. Mechanistically, loss of NEO1 induces intracellular iron deficiency, resulting in impaired prolyl hydroxylase-dependent degradation of HIF1/2α. This iron dysregulation is associated with reduced hepcidin expression and increased levels of the iron exporter ferroportin. Stabilized HIF1/2α preferentially engages HIF1β-p300 complexes at the VEGFa promoter to promote angiogenesis while reducing HIF1β-p300 occupancy at the MEGF10 promoter, thereby suppressing phagocytic gene expression. Together, these findings establish NEO1 as a critical cortical astrocytic regulator that balances vascular remodeling and phagocytic capacity through control of iron homeostasis and HIF-dependent transcription. - Source: PubMed
Publication date: 2026/03/10
Yao Ling-LingLee DaehoonWu Min-YiZou Wen-JunRen XiaoHu Jin-XiaWu AnikaXiong LeiMei LinXiong Wen-Cheng - The influence of paternity on progeny quality, particularly during early developmental stages, has long been underappreciated. However, altered sperm phenotypes are increasingly recognized as effective tools for identifying paternal-effect-associated genes (PEAGs), whose expression in the progeny is influenced by genetic or non-genetic factors carried by the sperm. This study investigated the impact of post-thaw sperm storage (PTS) as a stressor to verify its effect on larval performance in common garden rearing trial and to reveal PEAGs in Eurasian perch (Perca fluviatilis) progeny. In vitro fertilizations were performed using cryopreserved sperm that was either used immediately after thawing (0 min; CON) or after 30 min of post-thaw storage at 4 °C. - Source: PubMed
Publication date: 2026/02/20
Panda AbhipsaWałdowska SylwiaPalińska-Żarska KatarzynaDebernardis RossellaNynca JoannaRożyński RafałMajewska Anna MJastrzębski Jan PŻarski Daniel