PARVA antibody - C-terminal region (OAAB05910)
- Known as:
- PARVA (anti-) - C-terminal region (OAAB05910)
- Catalog number:
- oaab05910
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- PARVA antibody - C-terminal region (OAAB05910)
Related genes to: PARVA antibody - C-terminal region (OAAB05910)
- Gene:
- PARVA NIH gene
- Name:
- parvin alpha
- Previous symbol:
- MXRA2
- Synonyms:
- FLJ12254, FLJ10793
- Chromosome:
- 11p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-26
- Date modifiied:
- 2018-03-02
Related products to: PARVA antibody - C-terminal region (OAAB05910)
Related articles to: PARVA antibody - C-terminal region (OAAB05910)
- Tick-borne protozoa of the genus Theileria, particularly T. parva, represent a major challenge to cattle production in sub-Saharan Africa. Recent outbreaks clinically ascribable to East Coast fever (ECF) in Maputo Province, southern Mozambique, highlight the need to investigate the occurence of Theileria parva and other Theileria species in local tick populations. This study aimed to investigate the presence and molecular diversity of Theileria spp. in ixodid ticks collected from cattle in the buffer zone of Maputo National Park. Between May 2023 and February 2024, 881 adult ticks were collected from six farms located in three villages. Four species were identified: Rhipicephalus microplus, Rhipicephalus evertsi, Amblyomma hebraeum and Rhipicephalus appendiculatus. A total of 326 ticks were individually subjected to molecular analysis. Screening was performed using a real-time PCR targeting the LSU rRNA gene of Babesia and Theileria genera. Positive samples with a Ct ≤34 were further tested by a specific nested PCR targeting the T. parva p104 gene and by a nested PCR targeting the 18S rRNA gene, followed by Sanger sequencing and phylogenetic analysis. Overall, 62.6% (204/326) of ticks were positive at real-time PCR and further analysed. The p104 assay identified T. parva in 11 ticks and confirmed by sequencing. Most T. parva isolates clustered closely in phylogenetic analysis, indicating low genetic diversity among the analysed isolates, while one divergent isolate was detected in A. hebraeum. The 18S rRNA nested PCR yielded a positive result confirmed by sequencing in 1 specimen that was identified as T. velifera. These findings confirm the circulation of T. parva in tick populations from the study area, suggesting the need for continued clinical, serological and molecular surveillance in southern Mozambique. - Source: PubMed
Publication date: 2026/08/22
Zhang TingxiDotto GiorgiaGrillini MarikaFranzo GiovanniAfonso SoniaNeves LuisCassini RudiMucache Hermogenes - East Coast fever (ECF), caused by , remains endemic in Malawi. ECF vaccines and chemical treatments are regarded as expensive by small-holder farmers. The aims of this study were to clarify the epidemiology of ECF and to evaluate the efficacy of ethnoveterinary medicine, on infection. - Source: PubMed
Publication date: 2026/08/28
Kayira Gift KingsleyIshizaki TakahiroAsakura ShingoMatsuyama RyotaUkita MakotoHayashida KyokoHirata HaruyukiMakita Kohei - A -like bacterial strain, designated HYN0024, was isolated from lake water, and its taxonomic status was characterized in this study. Although the bacterium was isolated from an aerobic water sample, its cells were facultative anaerobes utilizing Fe(III) and oxygen as terminal electron acceptors. Phylogenetic analysis based on both genome and 16S rRNA gene sequences indicated that strain HYN0024 belongs to the family and forms a monophyletic clade with the type strains of , , and ''. However, the type strains of the genera and are currently unavailable from any public culture collections. Among the available type strains with validly published names, shared the highest 16S rRNA gene sequence similarity (98.35%) with strain HYN0024, but their average nucleotide identity (80.13%) was below the threshold for species delineation. The biochemical and physiological features also supported the distinctiveness of the isolate from previously known species. The 16S rRNA gene sequence similarity, genomic relatedness, phylogenetic tree topology, and phenotypic characteristics supported the taxonomic independence of the isolate as a novel species in the genus . Based on the phylogenetic and polyphasic taxonomic data presented in this study, we propose a novel species, sp. nov., for strain HYN0024 (= KACC 19179 = NBRC 112737). - Source: PubMed
Publication date: 2026/08/24
Baek Min-GyungSon Ji-HyeonYi HanaPark Sangcheol - Cancer hallmarks are characterized by wide-scale changes in gene expression programs. Pioneering studies showed how viral oncogenes target regulatory pathways, but little is known about tumorigenic mechanisms of non-viral pathogens. Theileria annulata is an intracellular parasite (related to apicomplexa parasites causing malaria) which remarkably transforms bovine leukocytes, hijacking host signaling pathways to induce cancer phenotypes, akin to human leukemias. While some host genes contribute to the proliferative or invasive hallmark phenotypes, there is still limited comprehensive understanding of the impact of Theileria infection on host transcription and transformation. We performed a multi-omics meta-analysis to investigate the effect of Theileria infection on cancer hallmarks in bovine B lymphocytes. Combining transcriptomic, proteomic and epigenomic analysis across multiple datasets, we show that Theileria infection suppresses host immune pathways. Specifically, genes encoding innate and adaptive immune mediators are repressed in T. annulata-infected B cells (and in T. parva infected T cells), including downregulation of genes for Toll-like receptors (TLR), inflammasome components of the guanylate binding protein (GBP) family and major histocompatibility complex class (MHC) II genes. Treatment with distinct theilericidal drugs could partially rescue immune gene expression. Mechanistically, we describe alterations in the host epigenome, including loss of activating histone modifications (e.g., H3K18ac, H3K4me3, H3K27ac) on the promoters of repressed immune genes, and enrichment of silencing marks (H3K27me3) on promoters of the BOLA genes and the gene encoding CIITA, the master transcriptional regulator of MHC class II gene expression. Our results suggest that intracellular T. annulata and T. parva parasites could drive an immune evasion cancer hallmark in host lymphocytes by epigenetic silencing of genes for innate and adaptive immunity. - Source: PubMed
Publication date: 2026/08/28
Giacomini MarisolPanagiotou AristeidisOdette Steve GHonfozo ArianeBerthelet JeremyAmo AngeliqueDybas Joseph MOrio-Tejada JuliaKulej KatarzynaVillares MarieGarcia Benjamin AHennion MagaliWeitzman Matthew DWeitzman Jonathan B - Ectoparasites cause skin lesions, anemia, and mortality in wild animals and act as vectors of zoonotic pathogens. This study reports ectoparasites detected during an opportunistic survey on wild mammals admitted to the Van Yuzuncu Yil University Wildlife Protection and Rehabilitation Center in eastern Türkiye during 2024-2025. Due to the opportunistic nature of sampling, the findings primarily reflect parasite burdens in injured or debilitated individuals and may not be representative of healthy free-ranging populations. Of the 28 animals examined, 20 (71.4%) were infested. A total of 449 ectoparasites were collected: 370 fleas (82.4%), 58 ticks (12.9%), and 21 lice (4.7%). Identified species included four fleas (, , , ), four ticks (, , , ), and one louse (). This study provides new host-ectoparasite association records for Türkiye: and on beech marten (); and on Eurasian badger (); and on Eurasian lynx () and brown bear (). Bipartite network analysis revealed moderate specialization (H2' = 0.52) and marked variation in host specificity, with , , and showing high host specificity (d' > 0.85), whereas and acted as generalists (d' < 0.30). Some identified ectoparasites are known or suspected vectors of zoonotic pathogens. These findings provide baseline data for future research on wildlife health and disease transmission risks in the region. - Source: PubMed
Publication date: 2026/08/04
Yılmaz Ali BilginAfşar MiladYasul MuhammedAfshar Mahsa TorkamanianAyan AdnanAyan Özge OktayGöz YaşarAslan Loğman