UK114 Antibody - C-terminal region (ARP52117_P050)
- Known as:
- UK114 Antibody - C-terminal region (ARP52117_P050)
- Catalog number:
- arp52117_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- UK114 Antibody - C-terminal region (ARP52117_P050)
Related genes to: UK114 Antibody - C-terminal region (ARP52117_P050)
- Gene:
- RIDA NIH gene
- Name:
- reactive intermediate imine deaminase A homolog
- Previous symbol:
- HRSP12
- Synonyms:
- UK114, P14.5, PSP
- Chromosome:
- 8q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-03
- Date modifiied:
- 2016-10-05
Related products to: UK114 Antibody - C-terminal region (ARP52117_P050)
Related articles to: UK114 Antibody - C-terminal region (ARP52117_P050)
- Growth monitoring and promotion (GMP) programmes have been implemented for decades in almost all countries. Despite this long history of implementation, GMP has been criticised for being ineffective, calling for a rethink of the programme. With a view of contributing evidence towards the redesign of GMP, we conducted a qualitative evaluation of the programme in various contexts of Ethiopia. We conducted focus-group discussions (FGDs; n = 28) and key informant interviews (KIIs; n = 193) with programme managers, service providers and caregivers beneficiaries. Supply-side, service delivery, and barriers hindering effective coverage were identified. Lack of functional weighing scales, budget constraints, limited transportation facilities, overlap of interventions, and the low motivation and performance of health workers were identified as main barriers affecting the quality-of-service delivery. The benefits of participating in GMP were not always clear to beneficiaries. Competing priorities like household chores, long travel distances to health centres, and in some contexts culturally insensitive practices deterred participation. Although GMP can serve as an entry point for mainstreaming nutrition into universal health coverage (UHC), the programme would need to be redesigned and supported by adequate supply, resources (financial and human), planning, and quality service delivery that is contextual and culturally sensitive. - Source: PubMed
Publication date: 2025/10/09
Gebremichael BereketBaye KaleabMaru YetayeshNoor RamadanhiMengistu FirehiwotDarsene HiwotSimachew YilkalDadi Tegene LDereje RahelChitekwe Stanley - Ulcerative colitis (UC) is a chronic inflammatory condition affecting the large intestine that can progress to colorectal cancer if left untreated. Different therapeutic approaches are used for its treatment and cyclosporine is one of them. It has been investigated as a rescue treatment option in cases when patients are unresponsive to steroidal therapy. However, its efficacy and safety remain uncertain. This study aims to conduct a comprehensive analysis of clinical evidence on cyclosporine safety and efficacy for the treatment of UC. - Source: PubMed
Publication date: 2025/10/09
Mehreen AqsaBatool FaizaAwan Uzma AzeemAslam ShaistaHaider AdnanUllah MuneebYoo Jin-WookSaeed Rida FatimaNaeem Muhammad - There is growing evidence of the involvement of gut microbiota in neurodegenerative diseases. However, the relationship between gut microbiota and prion diseases is not yet well understood. Prion diseases are neurodegenerative disorders affecting humans and animals and caused by an infectious misfolded protein known as prion. Among prion diseases, scrapie is the one affecting sheep and goats, and its classical form is typically acquired. In the present work, a 16S rRNA-based microbiome profiling was performed in faecal samples from 10 sheep infected with classical scrapie and 10 control sheep. The phyla Firmicutes and Bacteroidetes appeared as the most abundant phyla in scrapie and control sheep. Moreover, both groups of samples showed similar richness and alpha diversity indices. The gut microbiota profile in terms of beta diversity was significantly different in scrapie-infected sheep compared to the control group. Additionally, similarly to other neurodegenerative diseases, scrapie animals displayed a significant increased abundance of Cyanobacteria and Lentisphaerae phyla. Our results point to an altered gut microbiota in sheep infected with classical scrapie, with a specific increase of two phyla that could be involved in scrapie disease pathogenesis, enabling conceptual advances in the understanding of prion diseases. - Source: PubMed
Publication date: 2025/09/23
Hernaiz AdelaidaGrasa LauraDe Diego Abejón PaulaLeón Huertas CeliaMarín BelénBadiola Juan JoséBolea RosaZaragoza PilarMartín-Burriel Inmaculada - The overuse of carbapenems has driven the rise of carbapenem-resistant (CRPA) and (CRE), against which ceftazidime-avibactam (CAZ-AVI) offers an alternative treatment. This study phenotypically determined resistance profiles of (PA), (EC), and (KP) clinical isolates to CAZ-AVI and investigated molecular resistance mechanisms genotypically. A total of 394 PA, 90 EC, and 84 KP isolates were collected from the American University of Beirut Medical Center. Antimicrobial susceptibility testing (AST) and whole-genome sequencing (WGS) were performed on 30 isolates per species. Results showed that 100% of KP, 63% of EC, and 100% of PA isolates were carbapenem-resistant. Among these, 73% of KP, 79% of EC, and 60% of PA were CAZ-AVI-resistant. WGS revealed diverse sequence types, plasmids, and antimicrobial resistance genes. Additionally, 100% of KP, 93% of EC, and 89% of PA isolates produced metallo-β-lactamases (MBLs). Mutations in , , and were identified in CAZ-AVI-resistant, non-MBL-producing PA, whereas mutations in , , and were detected in CAZ-AVI-resistant, non-MBL-producing EC. While CAZ-AVI remains effective against most CRE and CRPA lacking MBLs, resistance to CAZ-AVI is multifactorial, commonly involving overexpression of efflux pumps and AmpC β-lactamases, loss of porin channels, and the presence of oxacillinases. - Source: PubMed
Publication date: 2025/08/29
Gerges Jose-RitaBarada SaraHussein HadiSleiman AhmadJabbour ZiadEl Rida FatimaKurdi AbdallahMatar GhassanAraj GeorgeAbou Fayad AntoineKanafani Zeina Adnan - Scrapie (classical and atypical) susceptibility in sheep is strongly influenced by gene polymorphisms. In Portugal, limited data exist for native breeds such as Serra da Estrela, despite their relevance to animal conservation and food production. The full coding region of gene of 92 Serra da Estrela sheep was sequenced and SNP frequencies were analysed. The predicted functional impact of nonsynonymous SNPs was assessed using PolyPhen-2 and AMYCO. A total of 27 SNPs were identified, including 20 nonsynonymous variants. Thirteen major haplotypes were observed. The ARR allele, which provides resistance to classical scrapie, was present in 58.7% of the population, with 18.5% of animals being homozygous. Several previously unreported SNPs were identified, and their impact on prion protein aggregation propensity and structure was explored. The high frequency of the ARR allele without full ARR fixation suggests that no selective breeding for scrapie resistance has been applied. These results support the adoption of gradual selection strategies that preserve genetic variability and promote farmer compliance, while increasing classical and atypical scrapie resistance. - Source: PubMed
Publication date: 2025/09/20
Rodrigues SoraiaMoreira GuilhermeSantos-Silva SérgioGomes-Gonçalves SaraAires Pereira MariaBaptista AlexandraCruz RitaEsteves FernandoMesquita João R