Tmed1 antibody - N-terminal region (ARP46796_P050)
- Known as:
- Tmed1 (anti-) - N-terminal region (ARP46796_P050)
- Catalog number:
- arp46796_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- Tmed1 antibody - N-terminal region (ARP46796_P050)
Related genes to: Tmed1 antibody - N-terminal region (ARP46796_P050)
- Gene:
- TMED1 NIH gene
- Name:
- transmembrane p24 trafficking protein 1
- Previous symbol:
- -
- Synonyms:
- ST2L, MGC1270, IL1RL1LG, Il1rl1l, p24gamma1, p24g1
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-07
- Date modifiied:
- 2015-08-11
Related products to: Tmed1 antibody - N-terminal region (ARP46796_P050)
Related articles to: Tmed1 antibody - N-terminal region (ARP46796_P050)
- Monieziosis caused by Moniezia spp. is an intestinal parasitic disease that deteriorates the health and productivity of small ruminants and may lead to death. This study aimed to estimate the monieziosis occurrence rate and its systemic impact in Zaraibi goats. Based on microscopic findings, molecular and phylogenetic analysis of the COX1 gene in Moniezia spp. infected goats (n = 380), twelve M. benedeni infected animals (MONZ, accession number OR053794) were enrolled in this study together with twelve healthy goats (Ctrl). The activities of hepatic (SA and SD), biliary (AP and γ-GT), and pancreatic (lipase and amylase) enzymes and the levels of globulin, T. Bilirubin, and creatinine were significantly increased (P ≤ 0.01) in the serum of infected goats. MONZ group displayed a significant increase in lipid profile (TC, TG, VLDL-C, and LDL-C, P ≤ 0.01) and a significant decrease in HDL-C (P ≤ 0.01) and PON-1(P ≤ 0.001). Positive APPs (CRP, haptoglobin, and α1-AGP) and proinflammatory cytokines (IL-33, IL-1β, and TNF-α) were significantly enhanced in the MONZ group. M. benedeni exacerbates a significant increase (P ≤ 0.001) of oxidative stress parameters (TOS, OSI, MDA, and GSSG) and a significant (P ≤ 0.001) consumption of the antioxidant defenses (TAS, SOD, CAT, GSH and GSH/GSSG). This oxidative burden mediates villous atrophy of enterocytes and Th2-biased immune response via the induction of TMED1/CD14+ mediated IL-33 signaling cascades, as well as LITAF-induced activation of TNF-α-dependent mRNA expression of NOX2-regulating subunit NCF4 pathway. This study clarified how M. benedeni could impair hepato-renal function, enterocyte integrity, redox signaling, and allergic inflammation-related genes at the intestinal tissue and systemic levels in goats. - Source: PubMed
Publication date: 2025/06/24
Abdelhamid MahmoudSelim Ahmed MagdyMohamed Ragab HassanMohamed Rasha SalahAteya AhmedAlmasoudi Suad HamdanAlexiou AthanasiosPapadakis MariosEl-Sebaey Ahmed M - Aortic stenosis (AS) is a valvular heart disease that obstructs normal blood flow from the left ventricle to the aorta due to pathological changes in the valve, leading to impaired cardiac function. Echocardiography is a key diagnostic tool for AS; however, its accuracy is influenced by inter-observer variability, operator experience, and image quality, which can result in misdiagnosis. Therefore, alternative methods are needed to assist healthcare professionals in achieving more accurate diagnoses. - Source: PubMed
Publication date: 2025/04/28
Gan YejiaHuang WanzhongDeng YanXie XiaoyingGu YuanyuanZhou YaozhuangZhang QianZhang MaoshengLiu Yangchun - Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with significant genetic heterogeneity. The ZIC gene family can regulate neurodevelopment, especially in the cerebellum, and has been implicated in ASD-like behaviors in mice. We performed bioinformatic analysis to identify the ZIC gene family in the ASD cerebellum. - Source: PubMed
Publication date: 2024/02/22
Li HeliCui JinruHu CongLi HaoLuo XiaopingHao Yan - Several TMED protein family members are overexpressed in malignant tumors and associated with tumor progression. TMED1 belongs to the TMED protein family and is involved in protein vesicular trafficking. However, the expression level and biological role of TMED1 in colorectal cancer (CRC) have yet to be fully elucidated. In this study, the integration of patient survival and multi-omics data (immunohistochemical staining, transcriptomics, and proteomics) revealed that the highly expressed TMED1 was related to the poor prognosis in CRC. Crystal violet staining indicated the cell growth was reduced after knocking down TMED1. Moreover, the flow cytometry results showed that TMED1 knockdown could increase cell apoptosis. The expression of TMED1 was positively correlated with other TMED family members (TMED2, TMED4, TMED9, and TMED10) in CRC, and the protein-protein interaction network suggested its potential impact on immune regulation. Furthermore, TMED1 expression was positively associated with the infiltration levels of regulatory T cells (Tregs), cancer-associated fibroblasts (CAFs), and endothelial cells and negatively correlated with the infiltration levels of CD4+ T cells, CD8+ T cells, and B cells. At last, the CTRP and GDSC datasets on the GSCA platform were used to analyze the relationship between TMED1 expression and drug sensitivity (IC). The result found that the elevation of TMED1 was positively correlated with IC and implied it could increase the drug resistance of cancer cells. This research revealed that TMED1 is a novel prognostic biomarker in CRC and provided a valuable strategy for analyzing potential therapeutic targets of malignant tumors. - Source: PubMed
Publication date: 2024/01/29
Guo XinZhou WeiJin JinmeiLin JiayiZhang WeidongZhang LijunLuan Xin - The members of the transmembrane emp24 domain-containing protein (TMED) family are summarized in human as four subfamilies, α (TMED 4, 9), β (TMED 2), γ (TMED1, 3, 5, 6, 7) and δ (TMED 10), with a total of nine members, which are important regulators of intracellular protein transport and are involved in normal embryonic development, as well as in the pathogenic processes of many human diseases. Here we systematically review the composition, structure and function of TMED family members, and describe the progress of TMED family in human diseases, including malignancies (head and neck tumors, lung cancer, breast cancer, ovarian cancer, endometrial cancer, gastrointestinal tumors, urological tumors, osteosarcomas, etc.), immune responses, diabetes, neurodegenerative diseases, and nonalcoholic fatty liver disease, dilated cardiomyopathy, mucin 1 nephropathy (MKD), and desiccation syndrome (SS). Finally, we discuss and prospect the potential of TMED for disease prognosis prediction and therapeutic targeting, with a view to laying the foundation for therapeutic research based on TMED family causative genes. - Source: PubMed
Publication date: 2023/10/16
Zhou LvLi HuaixuYao HuiDai XingliangGao PengCheng Hongwei