DONSON antibody - middle region (ARP45862_P050)
- Known as:
- DONSON (anti-) - middle region (ARP45862_P050)
- Catalog number:
- arp45862_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- DONSON antibody - middle region (ARP45862_P050)
Related genes to: DONSON antibody - middle region (ARP45862_P050)
- Gene:
- DONSON NIH gene
- Name:
- downstream neighbor of SON
- Previous symbol:
- C21orf60
- Synonyms:
- B17, C2TA, DKFZP434M035
- Chromosome:
- 21q22.11
- Locus Type:
- gene with protein product
- Date approved:
- 2000-02-18
- Date modifiied:
- 2017-03-30
Related products to: DONSON antibody - middle region (ARP45862_P050)
Related articles to: DONSON antibody - middle region (ARP45862_P050)
- Ependymoma (EPN) is an aggressive pediatric CNS tumor with poor survival and significant morbidity. As immune factors are associated with outcome, the potential for effective immunotherapy in posterior fossa (PF) EPN has been suggested. Based on the success of immune stimulants combined with an anti-GD2 monoclonal antibody in high-risk pediatric neuroblastoma, we hypothesized that a similar approach would be a plausible immunotherapy strategy for recurrent PF EPN. - Source: PubMed
Publication date: 2026/03/31
Griesinger Andrea MWidener MelissaDonson Andrew MMettetal AshleyHankinson Todd CHandler MichaelLevy Jean M MulcahyLindsay Holly BMacy Margaret EForeman Nicholas KDorris Kathleen - ZFTA-RELA is the most recurrent genetic alteration seen in paediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumours in mice. Despite its oncogenic potential, ZFTA-RELA (ZR) is observed nearly exclusively in childhood EPN, with tumours located distinctly in the supratentorial brain of the central nervous system. We proposed that specific chromatin modules accessible during brain development would render distinct cell lineage programs at direct risk of transformation by ZR. To test this hypothesis, we performed combined single-nucleus assay for transposase-accessible chromatin and RNA (snMultiome) sequencing of the developing mouse forebrain compared with ZR-driven mouse and human EPN. We demonstrated that specific developmental lineage programs present in transient progenitor cells and regulated by PLAG/L family transcription factors were at risk of neoplastic transformation. Binding of this chromatin network by ZR or other PLAG/L family motifs targeting fusion oncoproteins led to persistent chromatin accessibility at oncogenic loci and oncogene expression. Cross-species analysis of mouse and human ZR EPN revealed significant cell type heterogeneity indicating incomplete neurogenic and gliogenic differentiation, with a small percentage of cycling progenitor-like or radial glial-like cells that established a putative tumour cell hierarchy. In vivo lineage tracing studies identified neoplastic clones that aggressively dominated tumour growth and established the entire EPN cellular hierarchy. These findings identify developmental epigenomic states that are critical for fusion-oncoprotein-driven transformation and show how these states continue to shape tumour progression. - Source: PubMed
Publication date: 2026/03/25
Kardian Alisha SSun HuaIppagunta SiriLaboe NicholasVaradharajan SrinidhiYu KwanhaChen Hsiao-ChiEmanus ErikZheng TuyuDeneen Riley MConnelly Jon PWang Yong-DongZhan JiangshanLiu HengxiLowe KimberleyBugbee TaylorPathak RakeshBland AmandaMehta SanyaCochiolo SophieArabzade AmirHolcomb BlakeBudd Kaitlin MKembuan GabrieleWright TristenCaesar EmmaPark MaxwellHancock AmeliaGee DavidMurdoch JoelXiao YiMcBrayer Samuel KMerchant Thomas EQi JunDurbin Adam DSchwarz Lindsay AWang LiDonson Andrew MForeman Nicholas KAgnihotri SameerLavado AlfonsoBaker Suzanne JEllison David WLee Hyun KyoungPruett-Miller Shondra MBertrand Kelsey CDeneen BenjaminMack Stephen C - A substantial body of literature exists on the perioperative management of pharmacological agents specifically prothrombotic agents, antiplatelets, anticoagulants and disease-modifying antirheumatic drugs (DMARDs) aimed at mitigating risks associated with both the medications themselves and the comorbidities they treat. However, a clear and consistent consensus on best practice is either lacking or poorly defined especially in foot surgery. To address this gap, a working group of podiatric surgeons convened to develop a Clinical Consensus Statement (CCS) for the perioperative management of these drugs in foot and ankle surgery. - Source: PubMed
Tang JadePosmyk LesleyCowden JamesLang RichardMilnes HelenDonson Lorna - Meier-Gorlin syndrome (MGORS) is a rare primordial dwarfism characterized by microtia, patellar hypoplasia/aplasia, and short stature. Additional features may include skeletal, respiratory, urogenital, and endocrine abnormalities. 13 genes have been implicated, with , essential for replication fork stability and intra-S phase checkpoint activation, being the most recently identified. Only six patients with -related MGORS have been reported. This study expands the phenotype by presenting long-term follow-up and prenatal data in two affected siblings. - Source: PubMed
Publication date: 2026/02/02
Sezer AbdullahYalçın Fatma ZehraKolkıran AbdulkerimÇetinkaya Semra - Astroblastomas are rare brain tumors predominantly affecting children and young adults, for which molecular subtypes and clinical management remain undefined. - Source: PubMed
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