SLC25A34 antibody - middle region (ARP44183_P050)
- Known as:
- SLC25A34 (anti-) - middle region (ARP44183_P050)
- Catalog number:
- arp44183_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- SLC25A34 antibody - middle region (ARP44183_P050)
Related genes to: SLC25A34 antibody - middle region (ARP44183_P050)
- Gene:
- SLC25A34 NIH gene
- Name:
- solute carrier family 25 member 34
- Previous symbol:
- -
- Synonyms:
- DKFZp781A10161
- Chromosome:
- 1p36.21
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-03
- Date modifiied:
- 2016-10-05
Related products to: SLC25A34 antibody - middle region (ARP44183_P050)
Related articles to: SLC25A34 antibody - middle region (ARP44183_P050)
- Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature. Yet how these diverse signals are molecularly integrated remains unknown. Here we show that clock, diet, and temperature cues converge on the orphan mitochondrial transporter, SLC25A34, to orchestrate thermogenic cycling of lipid synthesis and oxidation. During sleep, the clock suppresses transcription through REV-ERBα. Waking, lipid-rich diets, or cold exposure abolish this repression, allowing lipolytic signals to stimulate expression via PPARα. SLC25A34 then imports oxaloacetate into mitochondria to accelerate the export of substrates used for acetyl-CoA production in the cytosol. This feeds into cytosolic lipid synthesis and transcriptional induction of mitochondrial biogenesis, which collectively promote mitochondrial lipid oxidation. Thus, SLC25A34 confers circadian, dietary, and environmental control of thermogenic metabolism through interorganellar lipid cycling. - Source: PubMed
Publication date: 2026/06/03
Karavaeva IuliiaBasse Astrid LindeTrammell Samuel A JHussain Mohammed FaizMarkussen Lasse KruseHavelund Jesper FIsidor Marie SophieRichter Hannah JChubanava SabinaDeleye YannKaiser ZafirShen YachenNeess DitteSass FrederikeFinger FabianMuntadas Lidia ArgemiTandio DavidMa TaoSustarsic Elahu GosneyEmbring HannesKristensen Cecilie KyndingMcIntyre Rebecca LMartinez Genesee JHusted Anna SofieEmmett Matthew JKipp Zachary AFrost MikkelJedrychowski Mark Pvan Weeghel MichelMajd HomaZhuravleva EkaterinaMcGarrah Robert WPlucinska KajaMidha Mohit KProkesch AndreasCohen PaulGranneman James GSeale PatrickHoutkooper Riekelt HHansen Jacob BGygi Steven PSchwartz Thue WGillum Matthew PaulHinds Terry DSoccio Raymond EdwardWhite Phillip JKunji Edmund R SMoritz ThomasTreebak Jonas TMandrup SusanneEmanuelli BriceKazak LawrenceFærgeman Nils JLazar Mitchell AGerhart-Hines Zachary - Colorectal cancer (CRC) is one of the most common malignancies of the digestive tract globally, characterized by high incidence, difficulty in early diagnosis, and poor prognosis. Traditional screening methods have limitations in sensitivity and specificity, thus necessitating the development of novel, efficient molecular diagnostic approaches. Recent studies have highlighted the crucial role of mitochondrial dysfunction in the initiation and progression of various cancers, suggesting that mitochondria-related genes (MRGs) could serve as promising diagnostic targets for CRC. In this study, we integrated transcriptomic data from 1174 samples across The Cancer Genome Atlas (TCGA) and multiple Gene Expression Omnibus (GEO) public datasets (GSE21510, GSE44076, and GSE9348) and combined it with MRG data from the MitoCarta3.0 database for a systematic analysis of differentially expressed genes (DEGs). Using LASSO regression and SVM-RFE, two machine learning algorithms, we identified eight key MRGs (ABCG2, ANK2, MACC1, PMAIP1, SLC22A5, SLC25A34, ACAT1, and PDK4) and constructed an early diagnostic model for CRC. Receiver operating characteristic (ROC) curve analysis confirmed the diagnostic efficacy of the model. Gene interaction networks were constructed using GeneMANIA, demonstrating the potential synergistic roles of these genes in regulating cellular metabolism, drug efflux, and immune modulation. CIBERSORT immune cell infiltration analysis revealed significant correlations between these genes and various immune cell subtypes, including T cells, macrophages, and dendritic cells. Further integration of single-cell RNA sequencing data (GSE245552) identified the specific expression patterns of the diagnostic model genes across different cell types. Additionally, we conducted an in-depth investigation of the ANK2 gene. Immunohistochemistry (HPA database), qRT-PCR, and western blotting confirmed the significantly low expression of ANK2 in CRC tissues and cell lines. Moreover, TUNEL and angiogenesis assays showed that overexpression of ANK2 significantly promoted cell apoptosis and inhibited angiogenesis, suggesting that ANK2 may function as a key tumor suppressor in CRC. In conclusion, this study proposes and validates a CRC diagnostic model based on differentially expressed mitochondrial genes. We systematically explored the molecular mechanisms and immune microenvironment correlations of the model and confirmed the biological effects through single-cell and molecular biology experiments. Notably, we highlight the potential regulatory role of ANK2 in the progression of CRC. This research provides theoretical support and new directions for early screening, diagnostic biomarker identification, and targeted therapy strategies for CRC. - Source: PubMed
Publication date: 2026/01/31
Ding XiangyuWu HuanhuanYang JiyuanSong HanGuo JianhuiWang XudongZhang XiaopengLi Zhengrui - Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by a dysregulated mucosal immune response in the intestine. The disease poses significant challenges for both diagnosis and treatment. This study aims to identify reliable biomarkers for UC and investigate its immunological characteristics, with the goal of improving diagnostic accuracy and informing treatment strategies. - Source: PubMed
Publication date: 2025/10/07
Qi YingchaoWang YichenZhang SiyaoPan XinxinLi WenkaiCheng MeijiaMa WenjingLi JiajiaPei YueLiu YunenYu Yongduo - The activation of macrophages or microglia in patients' whole body or local eyes play significant roles in diabetic retinopathy (DR). Mitochondrial function regulates the inflammatory polarization of macrophages. Therefore, the common mechanism of mitochondrial related genes (MRGs) and macrophage polarisation related genes (MPRGs) in DR is explored in our study to illustrate the pathophysiology of DR. - Source: PubMed
Publication date: 2025/01/06
Liu WeifengTong BinXiong JianZhu YanfangLu HongweiXu HaonanYang XiWang FeifeiYu PengHu Yunwei - The SLC25 family of transport proteins has been implicated in colorectal cancer (CRC) tumorigenesis. However, the potential role of SLC25A34 in CRC remains unclear. This study was designed to elucidate the role and mechanism of SLC25A34 in CRC. - Source: PubMed
Publication date: 2024/12/11
Li ChaoYu GangChen WanjingOuyang JijieWang XiaoshanWang Zhengguang