ZDHHC18 antibody - middle region (ARP42672_P050)
- Known as:
- ZDHHC18 (anti-) - middle region (ARP42672_P050)
- Catalog number:
- arp42672_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZDHHC18 antibody - middle region (ARP42672_P050)
Related genes to: ZDHHC18 antibody - middle region (ARP42672_P050)
- Gene:
- ZDHHC18 NIH gene
- Name:
- zinc finger DHHC-type containing 18
- Previous symbol:
- -
- Synonyms:
- DKFZp667O2416
- Chromosome:
- 1p36.11
- Locus Type:
- gene with protein product
- Date approved:
- 2003-03-21
- Date modifiied:
- 2016-02-15
Related products to: ZDHHC18 antibody - middle region (ARP42672_P050)
Related articles to: ZDHHC18 antibody - middle region (ARP42672_P050)
- The current work focused on elucidating the regulatory mechanisms of palmitoylation-related genes (PRGs) in influencing the occurrence and development of clear cell renal cell carcinoma (ccRCC), and identifying possible biomarkers and therapeutic targets. - Source: PubMed
Publication date: 2026/05/30
Li JunwuChang HaiXu HaoyuBai YuanyuanTang Wei - SARS-CoV-2 accessory protein ORF3a contributes to viral pathogenesis through membrane remodeling, immune evasion, and inflammation induction. However, the molecular mechanisms underlying ORF3a-mediated pathogenesis remain poorly characterized, and no therapeutic strategies targeting ORF3a currently exist. Here, we demonstrate that palmitoylation, a post-translational modification, governs ORF3a-mediated viral pathogenesis. Specifically, ORF3a undergoes ZDHHC18-mediated palmitoylation at evolutionarily conserved Cys130/Cys133 residues, which stabilizes the protein by masking an intrinsic proteasomal degradation signal. This palmitoylation competitively inhibits tripartite motif-containing 16 (TRIM16)-dependent K27-linked polyubiquitination, thereby preventing ORF3a degradation and enhancing viral replication and inflammatory responses. A designed ORF3a-mimicking palmitoylation-inhibitory peptide (OPIP) blocked ORF3a palmitoylation, promoted its degradation, and significantly reduced SARS-CoV-2 pathogenicity. Collectively, these findings establish ZDHHC18-mediated palmitoylation as a central regulator of ORF3a stability and virulence, revealing a potentially druggable axis for disrupting SARS-CoV-2 pathogenesis. - Source: PubMed
Publication date: 2026/05/10
Yang SidiLi KunLiu LihongZeng LinsenDeng QifengHuang JiachengDong XiaoranWang XinLiang JianweiLiu HongchaoPeng HongLin YuxinXie XiaoluYe YuzhenXu TiefengWang ZhaohuanLi Chun-MeiGuo Deyin - Although the acylation modification (AM) significantly influences the development of lung adenocarcinoma (LUAD), the specific mechanisms of acylation modification in this context have not been widely researched. This investigation sought to discover novel therapeutic avenues related to acylation modification for the precision treatment of LUAD. - Source: PubMed
Publication date: 2026/04/07
Xiao QifanBu JianlongLiu MengfengShi LeiQu Changfa - Protein palmitoylation, a key posttranslational modification, is involved in cell signaling, protein stability, and tumor immune microenvironment (TIME) regulation. ZDHHC3 is known to mediate clear cell renal cell carcinoma (ccRCC) immune evasion by enhancing PD-L1 stability, but the roles of other palmitoyltransferases in ccRCC remain unclear. In this study, we analyzed genomic and transcriptomic data via a multiomics approach to investigate the expression patterns and potential regulatory mechanisms of known palmitoylation enzymes in ccRCC. - Source: PubMed
Publication date: 2026/03/06
Guo ABaoLu YaoWang JunJia ZhanKuiYang JinJianNing Xianghui - Clear cell renal cell carcinoma (ccRCC) is a highly aggressive cancer with a poor prognosis. Palmitoylation, a posttranslational modification, plays a key role in regulating cancer progression and immune responses. However, its influence on ccRCC prognosis and immune therapy efficacy remains underexplored. - Source: PubMed
Publication date: 2025/11/29
Zhang DongZhang KeDeng MinghaoMa JiakangZhu JianShen ShuijieXie JianjunChen Chao