AFF2 antibody - middle region (ARP38099_P050)
- Known as:
- AFF2 (anti-) - middle region (ARP38099_P050)
- Catalog number:
- arp38099_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- AFF2 antibody - middle region (ARP38099_P050)
Related genes to: AFF2 antibody - middle region (ARP38099_P050)
- Gene:
- AFF2 NIH gene
- Name:
- AF4/FMR2 family member 2
- Previous symbol:
- FMR2
- Synonyms:
- FRAXE
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-27
- Date modifiied:
- 2019-03-26
Related products to: AFF2 antibody - middle region (ARP38099_P050)
Related articles to: AFF2 antibody - middle region (ARP38099_P050)
- Sinonasal carcinomas encompass a molecularly heterogeneous group of malignancies. fusion-associated carcinoma is a recently recognized subtype of nonkeratinizing squamous cell carcinoma characterized by deceptively bland morphology yet clinically aggressive behavior. We report the case of a 67-year-old woman who presented with a rapidly enlarging sinonasal mass with extensive local invasion involving both the intracranial compartment and orbit. Histologically, the tumor was composed of cytologically bland cells with monotonous nuclei and exhibited a combination of exophytic and endophytic growth patterns that closely mimicked a sinonasal papilloma. Although the tumor shows predominantly squamous differentiation, focal extracellular mucin was also present. The brain-invasive foci demonstrated tumor cells in sheets and nests floating within pools of mucin, a pattern focally reminiscent of mucinous adenocarcinoma. RNA sequencing identified a fusion with breakpoints at exon 7 and exon 6, confirming the diagnosis. The tumor demonstrated positive PD-L1 expression with a combined positive score (CPS) of 40 and a low tumor mutational burden (TMB) of 0.5 mutations/Mb. This case highlights the diagnostic challenges posed by fusion-associated carcinoma, underscores the importance of molecular profiling for accurate classification, and demonstrates the aggressive clinical behavior of this rare entity. - Source: PubMed
Publication date: 2026/09/15
Golden Katelyn ElizabethBarlow JoshYu HongHernandez David JEl-Dana FouadZarrin-Khameh NedaZhang SonglinLiang Li - Although the association between high-risk (HR) subtypes of human papillomavirus (HPV) and oropharyngeal carcinoma (OC) is well established, the role and biologic significance of low-risk (LR) HPV in these tumors remains poorly understood. In this series, we present 4 OCs with LR-HPV positivity by in situ hybridization (ISH). The cases occurred in 3 males and 1 female with a mean age of 67.8 years. All tumors demonstrated a papillary/exophytic architecture, and 2 showed overt stromal invasion. Morphologically, the tumors exhibited a spectrum ranging from keratinizing neoplasms with relatively low-grade cytologic features to predominantly non-keratinizing tumors with higher-grade cytology. Glandular differentiation was identified in one case. Koilocytic change was present in all tumors, while prominent intraepithelial neutrophils were identified in two cases. A possible squamous papilloma precursor lesion was present in two cases. All tumors were positive for LR-HPV RNA ISH and negative for HR-HPV RNA ISH. p16 immunohistochemistry was negative in 3 cases and equivocal in one. HPV6 DNA was confirmed in both tumors subjected to sequencing, which additionally identified alterations involving TERT, PIK3CA, FAT1, KRAS, and EP300. Rare OCs may demonstrate transcriptionally active LR-HPV expression and harbor molecular alterations commonly encountered in conventional HPV-independent squamous cell carcinoma. These tumors exhibit morphologic overlap with squamous papilloma, Schneiderian-like papilloma, adenosquamous carcinoma, mucoepidermoid carcinoma, and DEK::AFF2-rearranged carcinoma. While the significance of LR-HPV in these neoplasms remains uncertain, the findings expand the spectrum of HPV-associated lesions encountered in the oropharynx and provide a foundation for future mechanistic studies. - Source: PubMed
Publication date: 2026/09/07
Kmeid MichelGriffith Christopher CShah Akeesha ABishop Justin A - DEK::AFF2 fusion-associated carcinoma is a recently recognized subtype of nonkeratinizing squamous cell carcinoma that may be underdiagnosed due to overlap with benign sinonasal lesions and reliance on molecular confirmation. - Source: PubMed
Publication date: 2026/08/28
El Shatanofy MuhammadPena StefanieAaron TonyaTadesse Ammanuel KVelez Torres Jaylou MSweeny LarissaKaye Erin R - Copy number variations (CNVs) represent an important source of structural genomic variation contributing to genomic diversity in livestock species. The Nagami Mithun (Bos frontalis), a semi-domesticated bovid indigenous to the forested hill regions of Northeast India, remains poorly characterized at the level of genome structural variation. In this study, whole-genome resequencing data from 12 Nagami Mithun individuals were analyzed to establish the first genome-wide copy number variation (CNV) map for this indigenous population. After quality filtering and alignment to the Bos taurus ARS-UCD2.0 reference genome, CNVs were detected using the read-depth-based tool CNVnator v0.4.1 with stringent filtering criteria (e-value < 0.05, q0 < 0.5, length > 1 kb). A total of 7273 CNVs were identified, including 5005 deletions (68.8%) and 2,268 duplications (31.2%), which were subsequently integrated into 1135 CNV regions (CNVRs). Population-level integration of individual CNVs resulted in 1135 CNVRs spanning approximately 173.4 Mb of the autosomal genome. Functional annotations identified 2281 genes overlapping CNVRs. Gene Ontology enrichment analysis identified overrepresentation of genes annotated to chemosensory perception, immune-related processes, and amino-acid transport functions, while KEGG pathway analysis identified enrichment of pathways annotated as natural killer cell-mediated cytotoxicity and antigen processing and presentation. CNV-QTL overlap analysis identified hypothesis-generating candidate genomic regions harboring genes (e.g., AFF2, EDA, COL4A5, TRPC5) that are associated with production, reproduction, and conformation traits in bovines, representing putative positional overlaps requiring future validation in Mithun populations. This study provides a foundational structural variation resource for future comparative, conservation, and functional genomic studies in Mithun. These findings provide a valuable genomic resource for future marker-assisted selection, comparative genomics, and conservation breeding programs aimed at preserving Nagami Mithun populations. - Source: PubMed
Publication date: 2026/08/20
Kichu BendangkokbaKumar HarshitMondal RajkrishnaChotso KuluveChamuah J KHanah S SShivanagowda Girish Patil - DEK::AFF2 fusion-associated papillary squamous cell carcinoma is a recently characterized sinonasal neoplasm that closely mimics Schneiderian papilloma. Although one report has described fine-needle aspiration cytology of a metastatic lymph node, scrape cytological features from the primary site remain undocumented. - Source: PubMed
Publication date: 2026/08/17
Satomi HidetoshiHonma KeiichiroKukita YojiAshimura MinakoKoyanagi YukiKodama YoshinoriTanada Satoshi