CDX1 antibody - N-terminal region (ARP38075_P050)
- Known as:
- CDX1 (anti-) - N-terminal region (ARP38075_P050)
- Catalog number:
- arp38075_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CDX1 antibody - N-terminal region (ARP38075_P050)
Related genes to: CDX1 antibody - N-terminal region (ARP38075_P050)
- Gene:
- CDX1 NIH gene
- Name:
- caudal type homeobox 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-05
- Date modifiied:
- 2014-11-18
Related products to: CDX1 antibody - N-terminal region (ARP38075_P050)
Related articles to: CDX1 antibody - N-terminal region (ARP38075_P050)
- To observe the effect of electroacupuncture (EA) on gastric mucosal injury and necroptosis receptor-interacting protein kinase (RIPK)1/RIPK3/mixed lineage kinase domain-like (MLKL) signaling pathway in rats with precancerous lesions of gastric cancer, so as to explore its possible mechanism underlying improvement of gastric precancerous lesions (GPL). - Source: PubMed
Jiang TingLi Guan-YingWang XinTian Zhi-WenZhang Sheng-XiongPan Hua-ShanLiu Wei - Newborns' intestinal adhesions have been reported in 4.7% infants who underwent a laparotomy, but adhesions can also appear idiopathically. Etiology and pathogenesis of adhesions is still to be determined, but evidence shows relation to inflammation, formation of fibrin bands, hypoxia and tissue remodelation. Multiple candidate genes have been associated with adhesion development. The aim of this study was to evaluate the appearance of Sonic Hedgehog (SHH), Indian Hedgehog (IHH), Forkhead-box F1 (FOXF1), caudal type homeobox 1 (CDX1), HCLS1-associated protein X-1 (HAX-1), GATA Binding Protein 4 (GATA4) and Granzyme-B (GZMB) proteins in infant adhesions and to describe possible interfactorial correlations. Adhesion affected tissue samples were collected from 14 patients under one year of age that underwent abdominal surgery to treat partial or complete intestinal obstruction. The control group consisted of 6 individuals that had surgical repairment of inguinal hernia. Routine staining and immunohistochemistry were performed. Immunopositive fibroblasts, macrophages, endotheliocytes, smooth muscle myocytes of blood vessel wall and mesotheliocytes were investigated. The relative distribution of all factors was evaluated by the semiquantitative counting method. Statistical analysis was done using non-parametric tests and correlations were calculated based on Spearman's correlation analysis. A statistically significant decrease was observed for SHH, IHH, FOXF1, GATA4 and partially for GZMB in the adhesion group. There were also decreased HAX-1 and CDX1 immunopositive structures in the adhesion group, however, without any statistical significance. SHH, IHH, FOXF1, GATA4 and GZMB might have a role in adhesion development among infant patients which could suggest a dysregulation of cellular events. Abundance of correlations between the gene protein appearances in different structures indicate the affected blood vessels, fibroblasts and macrophages, however, mesothelium seems not to be the key driver in the morphopathogenesis of adhesion development. - Source: PubMed
Publication date: 2026/02/10
Pauliņš ArvisJunga AnnaPilmane Māra - Marek's disease virus (MDV) is a highly contagious oncogenic alphaherpesvirus that continues to threaten global poultry production, highlighting the need for next-generation vaccines. Although in ovo delivery of conventional MDV vaccines has been effective, vaccine leakiness has accelerated viral evolution by promoting the selection of more virulent, immune-evasive strains. mRNA vaccines offer a flexible and rapidly adaptable platform capable of inducing potent immune responses, yet their application against MDV remains unexplored in the in ovo context. Here, we report the first in ovo administration of a bivalent MDV mRNA vaccine encoding glycoprotein B (gB) and phosphoprotein 38 (pp38). RNA sequencing of the spleen and bursa of Fabricius at 12-, 24-, and 48-hours post-vaccination revealed distinct, time- and tissue-specific transcriptional programs. In the spleen, differential expression analysis (fold-change ≥ 2, padj < 0.05) demonstrated early activation of caudal-type homeobox 1 (CDX1) and signal transducer and activator of transcription 1 (STAT1), together with interferon-stimulated antiviral genes MX dynamin-like GTPase 1 (MX1), 2'-5'-oligoadenylate synthetase-like (OASL), and interferon-induced protein with tetratricopeptide repeats 5 (IFIT5). In contrast, the bursa exhibited persistent modulation of colipase (CLPS), chymotrypsinogen B1 (CTRB1), and deoxyribonuclease I (DNASE1), indicating metabolic and apoptotic remodeling. These results demonstrate that in ovo mRNA vaccination against MDV rapidly activates organ-specific immune and metabolic pathways, providing a transcriptomic framework for the rational design of poultry mRNA vaccines. - Source: PubMed
Publication date: 2025/12/26
Shoja Doost JananYitbarek AlexanderWootton Sarah KBehboudi ShahriarSharif Shayan - Drug resistance remains a major clinical challenge in the treatment of colorectal cancer (CRC) with conventional chemotherapy regimens. Analyzing post-treatment changes in tumor cells and the tumor microenvironment (TME) is essential to understanding resistance development. We analyzed single-cell RNA sequencing (scRNA-seq) data derived from 50 colorectal cancers (CRCs). This cohort included 30 treatment-naïve tumors (25 microsatellite stable (MSS) and five microsatellite unstable (MSI)) and 20 tumors that had previously received standard chemotherapy (comprising 14 responders and 6 progressors). Compared to MSS tumors, MSI tumors exhibited an immune-enriched tumor microenvironment (TME), marked by higher cytotoxic T cell activity and a less pronounced mesenchymal phenotype. Primary left-sided CRCs were associated with metastatic potential and depleted B cells. In post-treatment CRC, responders showed a high prevalence of a dendritic cell (DC) TME signature, which correlated with better survival in TCGA. Progressors showed TME enrichment of pericyte-like fibroblasts (associated with poor survival) and elevated exhausted CD8 T cells, suggesting a pro-inflammatory TME. Progressor tumor cells also expressed two chemo-protective markers, MTRNR2L1 and CDX1, co-expressed with the stemness-related immune-checkpoint CD24. In summary, scRNA-seq reveals distinct prognostic markers and features underlying progression to chemotherapy in MSS CRC. - Source: PubMed
Publication date: 2025/11/09
Puzanov Grigory AAstier ClémencePapakonstantinou DimitrisQuiroga Londoño MarianaBlériot CamilleYurchenko Andrey ABani Mohamed AmineJules-Clement GérômeAndre FabriceMarabelle AurélienHollebecque AntoineNikolaev Sergey I - Oral squamous cell carcinoma (OSCC) is a highly prevalent head and neck malignancy with a poor prognosis, often exhibiting resistance to conventional therapies. This highlights an urgent need for reliable biomarkers to facilitate early detection and effective management of recurrent or metastatic cases. Leveraging multi-omics analysis, we identified the HOX gene family as significantly overexpressed and closely associated with OSCC progression. Among these, HOXC9 was prioritized as a key regulator using machine learning algorithms. Mechanistic investigations revealed a strong correlation between HOXC9 expression and DNA hypomethylation at the CDX1 motif, which play a crucial role in regulating MMP13 expression. Single-cell RNA sequencing further elucidated the role of HOXC9 in driving OSCC malignant transformation. Clinical evidence demonstrates that HOXC9 promotes OSCC invasion and metastasis through the ITGA6/PI3K/Akt/MMP13 signaling axis. Additionally, HOXC9 expression appears to be modulated by miR-196, presenting a potential target for therapeutic intervention in OSCC. - Source: PubMed
Publication date: 2025/09/10
Xu MengyuSun ZewenWang DandanLi GuoxinFeng WeiQiao ChunyanShi CeLiu QilinChen PengAn Zhengwen