FOXJ1 antibody - N-terminal region (ARP38038_P050)
- Known as:
- FOXJ1 (anti-) - N-terminal region (ARP38038_P050)
- Catalog number:
- arp38038_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- FOXJ1 antibody - N-terminal region (ARP38038_P050)
Related genes to: FOXJ1 antibody - N-terminal region (ARP38038_P050)
- Gene:
- FOXJ1 NIH gene
- Name:
- forkhead box J1
- Previous symbol:
- FKHL13
- Synonyms:
- HFH-4, HFH4
- Chromosome:
- 17q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-11-13
- Date modifiied:
- 2015-08-25
Related products to: FOXJ1 antibody - N-terminal region (ARP38038_P050)
Related articles to: FOXJ1 antibody - N-terminal region (ARP38038_P050)
- Tubal infertility is one of the major causes of female infertility. This study aimed to investigate the mechanism of action of tubal patency decoction (TPD) and its active ingredient β-sitosterol on tubal infertility. - Source: PubMed
Shao LiangWang NansuYan YanTan QiongfangHuang YuyingWu QinTan YaliZhu YueXia YaqiongLiu Ling - Chronic rhinosinusitis (CRS) often recurs after surgery due to biofilms and inflammation, as current therapies have poor mucosal retention and limited biofilm penetration. We developed a natural hydrogel combining xylitol and hyaluronic acid (HA) to enhance drug delivery and antibiofilm efficacy. - Source: PubMed
Publication date: 2026/06/29
Huang JibinWang JiayanWang WeiXu Ming - In Xenopus laevis, multiciliated cells (MCCs) in epidermis produce coordinated motile cilia to promote fluid flow across epithelial surfaces. In a previous study, it has been reported that Bmp signaling negatively regulates the multiciliated cell formation. However, Bmp signaling is required for the early ectodermal patterning and epidermal specification. - Source: PubMed
Publication date: 2026/06/29
Kaushik NehaRehman Zia UrPark SoochulLee Seung-HwanLee UnjooKim Jaebong - Primary human basal bronchial epithelial cells (HBECs) are an important population of progenitor cells capable of self-renewal and differentiation to maintain airway homeostasis. In air-liquid interface (ALI) culture, HBECs undergo mucociliary differentiation, providing a robust physiologic model to evaluate novel therapeutics such as in vitro-transcribed messenger RNA (IVT-mRNA). However, the impact of IVT-mRNA delivery on the differentiation potential of basal HBECs remains poorly characterised. Poly(beta amino) ester (PBAE) nanoparticles have demonstrated effective airway delivery of IVT-mRNA in various preclinical studies. Here, we aimed to understand the impact of PBAE-mediated mRNA transfection on basal HBEC differentiation at the ALI. We investigated IVT-mRNA encoding the ciliogenesis transcription factor Forkhead box J1 (FOXJ1) as a model tool for transient overexpression in primary basal HBECs and characterised its subsequent impact on epithelial integrity and differentiation at the ALI. PBAE-mediated delivery of FOXJ1 mRNA to submerged primary HBECs resulted in approximately 50% FOXJ1-positive cells and transient upregulation of key ciliogenesis-related genes, including DNALI1 and RSPH9. Following 28 days of differentiation at the ALI, FOXJ1- or reporter mRNA-transfected cultures displayed normal epithelial morphology, with tight junction and differentiation markers, proportions of secretory and ciliated cells, and ciliary ultrastructure comparable to those of non-transfected controls. These data indicate that PBAE-mediated IVT-mRNA delivery can transiently increase encoded protein expression in basal primary HBECs without impeding mucociliary differentiation. - Source: PubMed
Publication date: 2026/06/12
Konstantinidi RafaelaSubramanian MiraYates LauraLloyd Clare MSaglani SejalPatel Asha K - Ciliated epithelial change in endometrial lesions is a recognized morphologic finding, but its immunophenotypic correlates and biological significance remain insufficiently defined. We investigated whether endometrial lesions with ciliated epithelial change show reproducible immunohistochemical alterations across benign, premalignant, and malignant diagnostic categories. We performed a retrospective immunohistochemical study of 315 formalin-fixed paraffin-embedded eutopic uterine endometrial specimens (no endometriotic/ectopic lesions included) collected between 2019 and 2024 and distributed equally across seven diagnostic categories ( = 45 each): normal endometrium, endometrial polyp, hyperplasia with cystic/disordered glands, hyperplasia with crowded glands, atypical hyperplasia/EIN, endometrioid carcinoma, and serous carcinoma. Marker expression was quantified by digital image analysis and compared between lesions with and without ciliated epithelial change, including lesions with ciliated epithelial change showing cytological atypia. Ciliated epithelial change (CEC) was identified in 86/315 cases (27.3%), including 41 cases (13.0%) with atypical CEC. In benign categories, lesions with CEC showed lower E-cadherin expression and higher β-catenin expression, including more frequent nuclear β-catenin localization. In carcinomas, these patterns were not recapitulated and instead showed an opposite or attenuated profile, supporting a context-dependent rather than linear model. Vimentin was consistently reduced in lesions with CEC across diagnostic categories. p53 and CD44 showed heterogeneous findings and were less informative than the adhesion- and phenotype-related markers. Endometrial lesions with CEC show reproducible, context-dependent immunohistochemical alterations, most consistently involving E-cadherin, β-catenin, and vimentin. In particular, nuclear β-catenin reactivity in this setting should not be interpreted as evidence of canonical Wnt-pathway activation in the absence of CTNNB1 sequencing or validated downstream readouts, and the carcinoma findings cannot be assigned to a specific TCGA/ProMisE molecular subgroup using immunohistochemistry alone. The observations should therefore be regarded as exploratory and warrant validation in studies incorporating molecular classification, direct ciliogenesis markers (FOXJ1, acetylated α-tubulin, basal body markers), and outcome data. - Source: PubMed
Publication date: 2026/05/27
Turashvili TeonaTevdorashvili GeorgeBurkadze George