FBN1 antibody - N-terminal region (ARP37969_P050)
- Known as:
- FBN1 (anti-) - N-terminal region (ARP37969_P050)
- Catalog number:
- arp37969_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- FBN1 antibody - N-terminal region (ARP37969_P050)
Related genes to: FBN1 antibody - N-terminal region (ARP37969_P050)
- Gene:
- FBN1 NIH gene
- Name:
- fibrillin 1
- Previous symbol:
- FBN, MFS1, WMS
- Synonyms:
- MASS, OCTD, SGS
- Chromosome:
- 15q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1987-09-11
- Date modifiied:
- 2019-04-23
Related products to: FBN1 antibody - N-terminal region (ARP37969_P050)
Related articles to: FBN1 antibody - N-terminal region (ARP37969_P050)
- To explore the correlation between clinical manifestations and variants of fibrillin-1 (FBN1) gene in eight patients with Marfan syndrome (MFS). - Source: PubMed
Wu RenhuaSun LeiLiu BaozhuFu XiaoLi XiaoyanWang Yueli - Marfan syndrome is a connective tissue disorder affecting the cardiovascular, skeletal, and ocular systems. Here, we generated and characterized induced pluripotent stem cell (iPSC) lines derived from two Marfan syndrome patients with mutations in the FBN1 gene (c.3333C > A and c.8854_8562delinsTATCAC). Both lines exhibited typical iPSC morphology, normal karyotype, undifferentiated states, and trilineage differentiation capacity. These iPSCs serve to enable investigation into the mechanisms underlying Marfan syndrome for therapeutic discovery. - Source: PubMed
Publication date: 2026/08/22
Mui Byron W HChorsi Mey-SamYan Christopher DChao Jade TWu Joseph C - Colorectal cancer (CRC) is a common and aggressive malignancy with poor prognosis. The efficacy of radiotherapy is often limited by the development of radioresistance, which can be attributed to various factors, including the extracellular matrix (ECM). The effect of radiotherapy on the ECM proteome remains poorly understood. We investigated changes in the proteome composition of CRC tumors after radiation therapy. Quantitative LC-MS/MS analysis of the purified ECM fraction was performed, that was supplemented by transcriptomic analysis of clinical samples obtained from patients after neoadjuvant radiochemotherapy. Radiotherapy markedly increased the number of identified ECM proteins, with the number of identified matrisome proteins rising from 45 to 87. In the irradiation group, 12 proteins showed significant upregulation (FDR-adjusted < 0.01), with fibrillin-1 (Fbn1) showing the greatest increase (632-fold). Structural ECM components, in particular glycoproteins, constituted the majority of proteins with significantly increased abundance. Transcriptomic analysis confirmed the upregulation of key ECM proteins in clinical samples and their positive correlation with the gene signatures of cancer-associated fibroblasts. We conclude that radiotherapy causes significant remodeling of the CRC ECM with predominant upregulation of structural components, indicating the induction of a fibrotic response. The identified proteins may serve as new biomarkers of the response to radiation and potential targets for overcoming radioresistance in CRC. - Source: PubMed
Amikishiev Sahil VKuzmina Darya OYuzhalin Arseniy E - Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated pleiotropic protective effects beyond glycemic control; however, their pharmacological impact on cytoskeletal remodeling and proteostatic regulation remains poorly defined. This study investigated whether SGLT2 inhibition modulates cytoskeletal-proteostatic signaling through the AGE-RAGE axis in diabetic conditions. - Source: PubMed
Publication date: 2026/08/14
Yeh Tung-ChenSun Gwo-ChingTseng Ching-JiunnChen Ying-YingCheng Pei-Wen - The vascular system is the largest organ in the body and underlies most chronic diseases, yet the molecular mechanisms that govern its plasticity remain poorly defined. - Source: PubMed
Publication date: 2026/08/13
Amrute Junedh MJiang LihuaBolar NikhitaHiga KellyZhu ChenchenJian RuiqiKim JenniferDuda MatthewPuaala Anna MarieKlinder AvaniDalal AlexPedroza AlbertReinhardt Dieter PCheng PaulSnyder MichaelFischbein Michael P