Gata5 antibody - N-terminal region (ARP37853_P050)
- Known as:
- Gata5 (anti-) - N-terminal region (ARP37853_P050)
- Catalog number:
- arp37853_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- Gata5 antibody - N-terminal region (ARP37853_P050)
Related genes to: Gata5 antibody - N-terminal region (ARP37853_P050)
- Gene:
- GATA5 NIH gene
- Name:
- GATA binding protein 5
- Previous symbol:
- -
- Synonyms:
- bB379O24.1, GATAS
- Chromosome:
- 20q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-17
- Date modifiied:
- 2015-09-11
Related products to: Gata5 antibody - N-terminal region (ARP37853_P050)
Related articles to: Gata5 antibody - N-terminal region (ARP37853_P050)
- Abscisic acid (ABA) is a key phytohormone that regulates seed germination, stomatal closure, and responses to abiotic stresses. The biosynthesis and signaling of ABA are controlled by a complex gene network, with serving as the rate-limiting enzyme in ABA biosynthesis and acting as a central transcription factor in ABA signaling. However, upstream regulators that coordinately control both processes during seed germination remain incompletely understood. In this study, we investigated the role of , a GATA transcription factor in , in ABA-mediated seed germination. To assess the germination phenotype under ABA treatment and the expression of ABA-related genes, we performed a transient activity assay (TAA) using protoplasts and gene expression analysis in transgenic plants. -overexpression (-OX) plants exhibited significantly reduced germination rates under exogenous ABA compared with wild type (WT), and mutant, generated by CRISPR/Cas9-mediated genome editing, showed a similar ABA-hypersensitive phenotype. The expression levels of and were markedly elevated in -OX plants, and TAA confirmed that AtGATA5 upregulates the promoter activities of both and . These findings suggest that plays a functional role in ABA-mediated seed germination by modulating and expression, and that AtGATA5 may represent a novel regulator of ABA homeostasis in plants. - Source: PubMed
Publication date: 2026/06/11
Kim ByeonggyuKim KihwanKim Won-Chan - Enhancing cotton yield remains a paramount breeding objective. Given limited arable land, increasing planting density is an effective strategy to boost cotton yield. However, the genetic basis of plant architecture suitable for high-density planting, particularly the molecular mechanism controlling fruit branch angle (FBA), remains largely unknown. This study identified qFBA-A11, a major QTL regulating FBA, using a Gossypium hirsutum × G. mustelinum introgression lines population. Map-based cloning revealed that GhFBA1_At was the major gene positively regulating FBA. GhFBA1_At encodes a protein with no known functional domains. Further investigations identified that GATA5, a light-responsive transcription factor, is a positive regulator of GhFBA1_At expression. The GhFBA1_At protein inhibited KNAT7 accumulation through direct protein-protein interaction and downregulated the expression of cell wall biosynthesis-related genes. This process promoted cell expansion while reducing cell wall thickness, ultimately weakening the mechanical strength of the cell wall and leading to a loose plant architecture. A structural variation (SV) at the GhFBA1_At locus in G. mustelinum caused complete gene loss, resulting in a compact plant architecture. Phylogenetic analysis showed that this SV was unique to G. mustelinum. CRISPR-Cas9 editing of GhFBA1_At generated a compact plant architecture and enhanced cotton yield under high-density planting. Our findings established GhFBA1_At as a crucial regulator of FBA, elucidated its molecular mechanism, and provided valuable germplasm resources for ideal plant architecture breeding in cotton. - Source: PubMed
Publication date: 2026/06/08
Xu ZhiyongFu ChaoLe YuChen MeilinLi YuanxueYang NingyuHui LiuyangZhang XianlongYang YangLin Zhongxu - To define CSC genetic architecture and identify implicated ocular tissues, cell types, genes, and circulating proteins. - Source: PubMed
Publication date: 2026/05/22
Chen LiyinKim Soo HyunTruong BuuRämö Joel TGorman Bryan Rvan Dijk Elon H CBrinks JoostNikopensius TiitChoi Seung HoanKajanne RistoMehtonen JuhaKaarniranta KaiSobrin LuciaKurki MitjaYzer Suzanne Wu Wen-ChihTurunen Joni ASegrè Ayellet JMercader Josep MariaHuerta AliciaDaly Mark JPalotie AarnoEllinor Patrick TBoon Camiel JfIyengar Sudha KPeachey Neal SNatarajan PradeepRossin Elizabeth J - To characterize age-associated alterations in intestinal barrier homeostasis by integrating host transcriptomic profiles and mucosa-associated microbial sequence signals recovered from human colonic biopsy RNA-seq datasets. - Source: PubMed
Publication date: 2026/06/02
Akinsuyi Oluwamayowa SOjeda AmandaXhumari JessicaRuggles Jarrod VSantos de Freitas AndersonRoesch Luiz F W - Understanding the development and differentiation of cardiac progenitor cells during the initial stages of embryogenesis is central to a complete understanding of vertebrate heart development. In zebrafish, cardiac specification begins during gastrulation; however, the single-cell transcriptional dynamics of initial cardiac lineage commitment remain not fully defined. In this case, we integrated single-cell RNA sequencing datasets of zebrafish embryos at 4 and 6 h post-fertilisation (hpf) to investigate early cardiac lineage specification. The unsupervised clustering of the integrated dataset identified 12 distinct cell clusters, which made it possible to identify a transcriptionally distinct population of cells characterised by the coordinated expression of transcription factors associated with cardiac development. A further subclustering of the cells expressing cardiac-associated transcription factors showed a significant level of early diversification of the cardiac progenitor group. A projection onto low-dimensional embedding revealed a structured transcriptional organisation of the cardiac subclusters, marked by the differential expression of key cardiac transcription factors, including Gata5, Gata6, Hand2, Nkx2.5, and Tbx5a. A pseudotemporal trajectory analysis uncovered a continuous developmental progression within the cardiac lineage and indicated the gene-specific dynamic regulation and temporal hierarchy of cardiac transcriptional programs. Collectively, these results indicate that zebrafish cardiac progenitors are transcriptionally diverse and acquire cardiac fate through a sustained, continuous regulatory process rather than an abrupt fate transition. This work provides an informative, high-resolution model of early cardiac lineage specification and highlights the power of single-cell transcriptomics for analysing dynamic events in vertebrate embryogenesis. - Source: PubMed
Publication date: 2026/05/15
Khalaf Samer NAl-Okhedi Mundher JabbarAlayed Amal SaeedJaddah Mariam MAbdul-Jalil Asra'a Adnan