LASS5 antibody - N-terminal region (ARP37810_P050)
- Known as:
- LASS5 (anti-) - N-terminal region (ARP37810_P050)
- Catalog number:
- arp37810_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- LASS5 antibody - N-terminal region (ARP37810_P050)
Related genes to: LASS5 antibody - N-terminal region (ARP37810_P050)
- Gene:
- CERS5 NIH gene
- Name:
- ceramide synthase 5
- Previous symbol:
- LASS5
- Synonyms:
- Trh4, MGC45411, FLJ25304
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-11
- Date modifiied:
- 2015-08-27
Related products to: LASS5 antibody - N-terminal region (ARP37810_P050)
Related articles to: LASS5 antibody - N-terminal region (ARP37810_P050)
- A comprehensive bioinformatics analysis of the expression of sphingosine-related genes and prognosis of patients with head and neck squamous cell carcinoma (HNSCC) was performed using TCGA data and TIMER. A keyword search using sphingosine identified 29 genes, 10 of which were associated with patient survival. The expression of CERS2, CERS5, PLPP3, SGPP1, and S1PR4 significantly differed between tumors and normal tissue. A protein-protein interaction analysis revealed a dense network of these genes. Survival rates decreased in patients with the high expression of CERS2, CERS5, and SGPP1, and increased in those with the high expression of PLPP3 and S1PR4. An examination of the relationship between the expression of these five genes and classical clinical risk factors revealed that the high expression of CESR5 negatively correlated with survival for all classical clinical risk factors, while that of S1PR4 positively correlated with survival. The TIMER analysis showed that CERS5 and S1PS4 expression on tumor-infiltrating immune cells from HNSCC patients was associated with survival. Collectively, these results indicate the potential of CERS5 as a marker of a poor prognosis, and the contribution of S1PR4 to a favorable prognosis through its expression on immune cells. Therefore, the expression of sphingosine-related genes on tumor cells and infiltrating immune cells is important for the prognosis of HNSCC patients. - Source: PubMed
Publication date: 2026/05/21
Hamada MasakazuYura YoshiakiUzawa Narikazu - Coffin-Siris syndrome (CSS) is predominantly attributed to variants in ARID1B gene, however, the molecular pathways connecting ARID1B to myelination and neural development are not well elucidated. - Source: PubMed
Publication date: 2026/04/10
Yang XingkunGan ZhongzhiZhou YasiZhang MingmingWu ShuijuanHe FeiShen ZongruiMa ShunfeiSu XiXiong Fu - Ceramide kinase (CerK) catalyzes the phosphorylation of ceramide to ceramide-1-phosphate (C1P), a bioactive sphingolipid with diverse signaling roles. While CerK has been identified in several cellular compartments, its presence and functional significance in kidney proximal tubules remain unexplored. Herein, we report the first characterization of CerK activity in basolateral membranes (BLMs) from porcine proximal tubule cells. We demonstrate that BLM fractions contain neutral and acidic sphingomyelinases, providing local substrate for CerK, which efficiently generates C1P under physiological pH (6.5-7.2) and temperature (30-37 °C) conditions. Enzyme activity was stimulated by cAMP in a protein kinase A-dependent manner but was not affected by angiotensin II. Lipidomic analysis confirmed the presence of C1P in human proximal tubule (HK-2) cells under basal conditions and revealed changes during ischemic stress. Transcriptomic analysis of kidney biopsies from patients with chronic kidney disease (CKD) further uncovered coordinated remodeling of sphingolipid metabolism genes, with increased expression of ceramidases (ASAH1 and NAAA) and downregulation of ceramide synthases (CERS4, CERS5), consistent with adaptive regulation of the Cer/CerK/C1P axis. Together, these findings identify for the very first time CerK activity in renal BLM, establish its biochemical requirements, and highlight its potential role in modulating transporter function and sphingolipid signaling in physiology and kidney disease. - Source: PubMed
Publication date: 2025/10/24
Grelle Gloria M R SCabral Lindsey M PAlmeida Fernando GTortelote Giovane GGarrett RafaelVieyra AdalbertoValverde Rafael H FCaruso-Neves CelsoEinicker-Lamas Marcelo - : Recent studies suggest that plasma ceramide levels may be better predictors of CVD risk than LDL cholesterol. Ceramides are part of the sphingolipid class of lipids and are the central intermediates in complex sphingolipid biosynthesis. Sphingolipids are crucial for cellular structure and have important biological roles as complex signaling lipids, structurally and functionally differentiated by their acylated fatty acid. Higher plasma concentrations of 16:0 ceramide are associated with increased risk of heart failure. In contrast, higher concentrations of 22:0 plus 24:0 ceramide are associated with lower risk. We aim to address how alterations in these lipids can affect the human cardiac hypertrophic response. : We silenced the ceramide synthase genes () responsible for the production of 16:0 ceramide (/) or 22:0 and 24:0 ceramide () in immortalized human ventricular cardiomyocytes and examined the altered cardiac hypertrophic response to phorbol 12-myristate 13-acetate treatment by examining changes in the transcriptome. : We discovered that silencing or / drastically altered the cardiac cell hypertrophic response. We demonstrated that human cardiomyocytes with silenced appeared to have an exacerbated hypertrophy response, while cardiomyocytes with silenced / had a more favorable response, suggesting that and / and their gene product metabolites may have opposing roles in the development and progression of CVD. : The exact mechanisms through which various ceramides contribute to CVD progression are still unknown. This study will help elucidate the role of specific ceramides during cardiac hypertrophy and suggests that drugs targeting specific sphingolipids can potentially be a viable treatment option for the prevention of CVD. - Source: PubMed
Publication date: 2025/09/22
Wiley Alexandra MKrueger Melissa ASotoodehnia NonaUmans Jason GHoofnagle Andrew NLemaitre Rozenn NTotah Rheem AGharib Sina A - Sphingolipids are a class of lipids that play important structural and functional roles in the cell. Specific ceramide species are distinguishable through the fatty acid that is acylated to the sphingosine backbone, leading to distinct biological activities. Generally, long-chain (LC) ceramides (16:0 and 18:0) drive metabolic dysfunction resulting in the progression of different disease states, while very long-chain (VLC) ceramides (22:0 and 24:0) are thought to be either beneficial against disease progression or benign. In this study, we sought to alter the cellular composition of LC and VLC ceramides in ventricular HCMs to investigate how alterations in these lipids can affect the transcriptome of otherwise healthy HCMs. Here, we used specific siRNA to knockdown the ceramide synthases responsible for the production of LC and VLC ceramides in ventricular HCMs and investigated the changes in the transcriptome of HCMs with or silenced compared to control conditions. Knocking down led to an increase in cell death as well as widespread reductions in cellular VLC sphingolipids. Additionally, we demonstrated that VLC sphingolipid species may play a protective role in maintaining cardiovascular function and that reducing these lipids may contribute to cardiac dysfunction. Similarly, knocking down CERS5 and CERS6 led to reduced LC ceramides and also resulted in profound changes in gene transcription. Interestingly, multiple genes and pathways were affected in the opposite direction when compared to the changes observed with the knockdown. Taken together, our results suggest pathways through which VLC ceramides may contribute to cardiac protection, and pathways where LC ceramides may promote HCM stress and the development of cardiac disease. - Source: PubMed
Publication date: 2025/08/31
Wiley Alexandra MKrueger Melissa ABecker Jessica OKarasu MatthewSotoodehnia NonaUmans Jason GHoofnagle Andrew NGharib Sina ATotah Rheem ALemaitre Rozenn N