ZNF581 antibody - N-terminal region (ARP37771_P050)
- Known as:
- ZNF581 (anti-) - N-terminal region (ARP37771_P050)
- Catalog number:
- arp37771_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF581 antibody - N-terminal region (ARP37771_P050)
Related genes to: ZNF581 antibody - N-terminal region (ARP37771_P050)
- Gene:
- ZNF581 NIH gene
- Name:
- zinc finger protein 581
- Previous symbol:
- -
- Synonyms:
- HSPC189, FLJ22550
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-15
- Date modifiied:
- 2014-11-19
Related products to: ZNF581 antibody - N-terminal region (ARP37771_P050)
Related articles to: ZNF581 antibody - N-terminal region (ARP37771_P050)
- The selective molecules for targeted therapy of triple-negative breast cancer (TNBC) are limited. Several kinases play pivotal roles in cancer development and malignancy. The study aims to determine if any kinases confer to malignancy of TNBC cells, which could serve as a theranostic target for TNBC. - Source: PubMed
Publication date: 2021/11/18
Chang Chia-CheChiu Chien-ChihLiu Pei-FengWu Chih-HsuanTseng Yen-ChiangLee Cheng-HsinShu Chih-Wen - Previous studies have revealed that transcription factors (TFs) play important roles in biparental (BI) early human embryogenesis. However, the contribution of TFs during early uniparental embryo development is still largely unknown. Here we systematically studied the expression profiles of transcription factors in early embryonic development and revealed the dynamic changes of TFs in human biparental and uniparental embryogenesis by single-cell RNA sequencing (scRNA-seq). In general, the TF expression model of uniparental embryos showed a high degree of conformity with biparental embryos. The detailed network analysis of three different types of embryos identified that 10 out of 17 hub TFs were shared or specifically owned, such as ZNF480, ZNF581, PHB, and POU5F1, were four shared TFs, ZFN534, GTF3A, ZNF771, TEAD4, and LIN28A, were androgenic (AG) specific TFs, and ZFP42 was the only one parthenogenetic (PG) specific TF. All the four shared TFs were validated using human embryonic stem cell (hESC) differentiation experiments; most of their target genes are responsible for stem cell maintenance and differentiation. We also found that Zf-C2H2, HMG, and MYB were three dominant transcription factor families that appeared in early embryogenesis. Altogether, our work provides a comprehensive regulatory framework and better understanding of TF function in human biparental and uniparental embryogenesis. - Source: PubMed
Publication date: 2021/09/17
Zhang ChenxiLi ConghuiYang LingLeng LizhiJovic DragomirkaWang JunFang FangLi GuiboZhao DepengLi XuemeiLin LinLuo YonglunBolund LarsHuang JinrongLin GeXu Fengping