KCNK5 antibody - C-terminal region (ARP37679_P050)
- Known as:
- KCNK5 (anti-) - C-terminal region (ARP37679_P050)
- Catalog number:
- arp37679_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- KCNK5 antibody - C-terminal region (ARP37679_P050)
Related genes to: KCNK5 antibody - C-terminal region (ARP37679_P050)
- Gene:
- KCNK5 NIH gene
- Name:
- potassium two pore domain channel subfamily K member 5
- Previous symbol:
- -
- Synonyms:
- K2p5.1, TASK-2
- Chromosome:
- 6p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-17
- Date modifiied:
- 2016-10-05
Related products to: KCNK5 antibody - C-terminal region (ARP37679_P050)
Related articles to: KCNK5 antibody - C-terminal region (ARP37679_P050)
- Endometriosis is a common complex gynecological condition that is difficult to efficiently diagnose and remains poorly understood. Menstrual fluid provides a non-invasive source of disease-relevant tissue and has been identified as promising for endometriosis diagnostics. Peripheral blood-based assays have yielded few clinically relevant targets, thus we hypothesize that cells specific to the uterus will exhibit more disease-related differences and may lead to insights into disease development and potential diagnostic markers. - Source: PubMed
Publication date: 2026/06/30
Leap KatieLepelletier AnthonyLiorzou EulalieDoridot LudivineBrulport AxelleBerthelot Camille - Selenium (Se) is known to improve gut health in animals, yet research on the effects of different dietary Se compounds on the intestinal health of broilers remains limited. Therefore, this study evaluated the effects of sodium selenite (SS), selenium-enriched yeast (SY), selenomethionine (SM), and nano-selenium (NS) on gut microbiota and their metabolites, intestinal antioxidant capacity, immune response, and gut morphology in broilers and investigated the potential molecular mechanisms by which Se influences intestinal function in broilers. A total of 360 1-d-old male yellow-feathered broilers with an average body weight of 37.00 ± 0.17 g were randomly assigned to five treatments, each comprising six replicates with 12 chicks per replicate. Broilers received either a basal diet or a basal diet supplemented with SS, SM, SY, and NS at 0.5 mg Se/kg for 56 d. Data were analyzed using one-way ANOVA with Tukey's post-hoc test for multi-group comparisons, and statistical significance was set at P < 0.05. Supplementation with SY increased ileal concentrations of secretory immunoglobulin A by 74.87% and interleukin-10 (IL-10) by 54.90%, enhanced ileal activities of total superoxide dismutase (T-SOD) by 123.55% and catalase by 197.20%, and elevated cecal acetate by 35.67% and total short-chain fatty acids (SCFAs) by 28.78%, as well as ileal ursodeoxycholic acid concentration by 154.05% (P < 0.05). Dietary SS elevated ileal IL-10 concentration by 44.72% and glutathione peroxidase activity by 93.74% while reducing tumor necrosis factor-alpha level by 26.46% (P < 0.05). Supplemental NS increased cecal concentrations of acetate by 45.56%, propionate by 85.94%, and total SCFAs by 39.68% (P < 0.05). Compared with the SS, SY supplementation improved jejunal total antioxidant capacity by 81.08% and ileal T-SOD activity by 84.22% (P < 0.05). Additionally, dietary Se supplementation increased the abundances of potentially beneficial bacteria, including Lactobacillus, Parabacteroides, Akkermansia, and UCG_005 (P < 0.05). Genes such as CCR9, CD28, MUC2, HTR6, KCNK5, and SLC9A3 were up-regulated, while GIP, SSTR2, SST1, and CRHR1 were down-regulated by SS or SY supplementation, indicating involvement in intestinal function. In summary, SS and SY improved intestinal antioxidant and immune functions in broilers, whereas SY and NS enhanced cecal SCFAs production. Moreover, Se supplementation modulated the cecal microbial community in broilers. - Source: PubMed
Chen JifaDai TianyueDeng JiayaoZhou JiayuPan YueXie HuiXu MingmingZhang HaiboZhang JiaxinQiu Guixiong - This study aims to delineate the molecular mechanisms through which aristolochic acid (AA) exposure drives renal cell carcinoma (RCC) pathogenesis, leveraging an integrated machine learning (ML) and multi-omics approach to systematically identify and validate key targets linking AA to RCC development. - Source: PubMed
Publication date: 2026/04/18
Zhang FanHan ShuaiPan DanGao LinaSong Weijie - The efficacy of nonsteroidal mineralocorticoid receptor blockers (MRBs) in inhibiting the progression of diabetic kidney disease (DKD) is well-known. However, MRB therapy often leads to hyperkalemia and remains a major concern. Recent studies suggest that combining potassium-retaining diuretics, renin-angiotensin system inhibitors, and sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduces the incidence of hyperkalemia. However, how SGLT2i, specifically affecting the proximal tubule (PT), suppresses hyperkalemia is unclear. This study aimed to elucidate the interaction between the aldosterone (Ald)/mineralocorticoid receptor (MR) signaling pathway and SGLT2i specifically in the PT, focusing on the synergistic effects on PT sodium (Na) and potassium (K) transport activity. - Source: PubMed
Publication date: 2025/12/11
Nakamura MotonobuSatoh NobuhikoMizuno TomohitoTakagi MayukoHorita ShokoNangaku Masaomi - Burkitt lymphoma (BL) is a highly aggressive B-cell lymphoma with its occurrence and progression closely associated with Epstein-Barr virus (EBV) status. However, the molecular differences between EBV-positive and EBV-negative BL have not been comprehensively evaluated. Through targeted sequencing of a 475-gene panel in 27 BL cases, and RNA-seq and LncRNA-seq analyses of 25 cases, we found that EBV-negative tumors displayed a higher frequency of chromosomal amplifications, particularly at 7p12.2, 6q25.3 and 7q22.1. Two novel variants of KMT2D were identified in adult patients in the EBV-negative group. Furthermore, EBV-positive BL exhibited enriched FOXO1 mutations, in contrast to CCND3 hotspot variants in EBV-negative cases. Transcriptome profiling revealed 1,612 differentially expressed genes (DEGs), predominantly involved in the PI3K-AKT, Hippo, WNT, and mTOR pathways. LncRNA profiling identified three EBV-associated lncRNAs ((MSTRG.103766.1, MSTRG.33752.11, ENSTO0000400385.2) with potential prognostic relevance in BL. Immune deconvolution (CIBERSORT/xCELL) demonstrated elevated M1 macrophages infiltration in EBV-positive BL, which correlated with improved 24-month overall survival (68% vs. 41%, p = 0.02). SULT1C2P1 and KCNK5 emerged as M1-associated prognostic biomarkers. Our findings establish EBV as a key modulator of BL genomic instability and immune remodeling, leading us to hypothesize that EBV status defines distinct BL subtypes with unique therapeutic vulnerabilities, thereby enabling the future development of EBV-stratified precision therapies. - Source: PubMed
Publication date: 2025/12/10
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