GRIK5 Antibody (ARP37674_P050)
- Known as:
- GRIK5 Antibody (ARP37674_P050)
- Catalog number:
- arp37674_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- GRIK5 Antibody (ARP37674_P050)
Related genes to: GRIK5 Antibody (ARP37674_P050)
- Gene:
- GRIK5 NIH gene
- Name:
- glutamate ionotropic receptor kainate type subunit 5
- Previous symbol:
- GRIK2
- Synonyms:
- GluK5, KA2
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-21
- Date modifiied:
- 2016-02-05
Related products to: GRIK5 Antibody (ARP37674_P050)
Related articles to: GRIK5 Antibody (ARP37674_P050)
- Hyperlipidaemia (HLP) arises from impaired lipid homeostasis in the setting of chronic low-grade inflammation, yet mechanistic comparisons between the edible medicinal fungi Cordyceps militaris and Ophiocordyceps sinensis remain scarce. Here, we combined chemical profiling with target/pathway prioritisation and structure-based modelling to define shared and species-specific lipid-regulatory features of these two fungi, followed by in vivo validation of cordycepin, a representative component of C. militaris, in high-fat diet (HFD)-fed mice. Integrated network analysis identified 72 common HLP-related targets, supporting convergence on inflammation-metabolism crosstalk. C. militaris displayed a more concentrated signature, characterised by GRIK family and proteasome-associated hubs and prominent enrichment of AMPK-related signalling. In contrast, O. sinensis was preferentially associated with upstream regulatory networks including insulin signalling, PI3K-Akt, MAPK and HIF-1. Molecular dynamics simulations showed relatively stable behaviour for the GRIK5-cordycepin and HCAR2-nicotinic acid complexes, whereas ERBB2-cerevisterol exhibited larger conformational fluctuation. MM-PBSA calculations further provided quantitative support for ligand-target association in the selected representative complexes. HPLC confirmed cordycepin as a characteristic component of C. militaris. In vivo, cordycepin improved fasting glucose and circulating lipid profiles, alleviated hepatic steatosis-like changes, and was accompanied by increased hepatic Prkaa1 and decreased Srebf1 expression. Collectively, these findings provide comparative computational insights into the hypolipidaemic potential of C. militaris and O. sinensis, while supporting cordycepin as a bioactive constituent of C. militaris associated with transcriptional changes related to AMPK/SREBP-1c signalling. The predicted regulatory features of O. sinensis still require direct experimental validation. - Source: PubMed
Publication date: 2026/05/09
Shi HuaijieZhang GuoyingLing Jianya - Autism spectrum disorder (ASD) is a genetically inherited, complex neuropsychiatric developmental condition that impacts a person's ability to learn, interact, and communicate. ASD is currently classified as a heterogeneous disorder, given that the pathophysiology of ASD is yet unknown. The GRIK gene family (GRIK1, GRIK2, GRIK3, GRIK4, and GRIK5) has genetic variants associated with many psychiatric illnesses including; depression, obsessive–compulsive disorder, and autism. The present study is the first to determine the possible association of GRIK1 rs363598 and intergenic rs360932 variants with susceptibility to ASD in Egyptian children and to correlate these variants with different parameters. - Source: PubMed
Publication date: 2025/12/01
Bassiony HebaBaiomy AhmedAhmed DoaaElaraby Nesma MAmmar Tamer H AAshaat Engy A - It has been shown previously that repeated positive fighting experience in daily agonistic interactions is accompanied by the development of psychosis-like behavior, with signs of an addiction-like state associated with changes in the expression of genes encoding the proteins involved in the main neurotransmitter events in some brain regions of aggressive male mice. Fighting deprivation (a no-fight period of 2 weeks) causes a significant increase in their aggressiveness. This paper is aimed at studying-after a period of fighting deprivation-the involvement of genes (associated with neurotransmitter systems within the nucleus accumbens) in the above phenomena. The nucleus accumbens is known to participate in reward-related mechanisms of aggression. We found the following differentially expressed genes (DEGs), whose expression significantly differed from that in controls and/or mice with positive fighting experience in daily agonistic interactions followed by fighting deprivation: catecholaminergic genes , , , , , and ; serotonergic genes , , , and ; opioidergic genes , , and ; and glutamatergic genes , , , , , , , and . The expression of DEGs encoding proteins of the GABAergic system in experienced aggressive male mice mostly returned to control levels after fighting deprivation, except for . In light of the conceptual paradigm for analyzing data that was chosen in our study, the aforementioned DEGs associated with the behavioral pathology can be considered responsible for consequences of aggression followed by fighting deprivation, including mechanisms of an aggression relapse. - Source: PubMed
Publication date: 2025/09/03
Kudryavtseva Natalia NSmagin Dmitry ARedina Olga EKovalenko Irina LGalyamina Anna GBabenko Vladimir N - Cancer stem cells are associated with tumorigenesis, aggression, and drug resistance. We aimed to identify stem cell-related subtypes and a prognostic tool, and to investigate potential stem cell-related genes contributing to high-grade serous ovarian cancer (HGSOC). - Source: PubMed
Publication date: 2025/07/23
Wu HuijuanLi DanSun LuSong HualinWang Ke - The biological damage caused by ionizing radiation (IR) depends not only on the time and doses of exposure to tissue components but also on the developmental state of the cells. Currently, amifostine is the only radiation-protective agent used for clinical indications related to radiation therapy, but this compound has multiple drawbacks including high toxicity, short half-life and no protective effect on the nervous system. Ursolic acid (UA), a natural pentacyclic triterpenoid that exhibits multiple protective effects including anti-inflammatory, anticarcinogenic, and antioxidant effects. Due to its poor solubility and bioavailability, UA is mostly administered with liposomes. In this study we investigated the impact of UA312, an optimized derivative of UA, on radiation-induced developmental toxicity in zebrafish embryos and larvae. Embryo and larvae survival were observed at 4, 24, 48, and 72 hpf. UA312 was administered at 3 hpf, while embryos were irradiated with 6 Gy of γ-irradiation (dose rate: 0.88 Gy/min) at 4 hpf, then the embryos were moved to a fresh buffer. We determined that 40 µM of UA312 was a safe concentration for zebrafish embryos and larvae. We found that treatment with UA312 (40 µM) restored IR-induced early developmental dysplasia of the zebrafish embryos and larvae. Transcriptomic analysis revealed that exposure to IR inhibited multiple pathways related to neurodevelopment and cardiomyocyte function in zebrafish, which were validated by assessing abnormal cardiac morphology, variations in neurotransmitter levels and alterations in locomotor behavior; and that UA312 treatment ameliorated these alterations. We demonstrated that UA312 treatment significantly reversed the related signaling pathways by targeting chrna3 and grik5. In conclusion, this study identified a promising radioprotective drug, UA312, which alleviates IR-induced cardiotoxicity and neurodevelopmental toxicity in zebrafish by targeting chrna3 and grik5. UA312 may be developed as a novel radioprotective agent against acute IR damage in humans. - Source: PubMed
Publication date: 2025/04/28
Xu Fei-FeiShang YueWei Hui-QiangZhang Wei-YingWang Li-XingHu TongZhang Shu-QinLi Yan-LiShang Hai-HuaHou Wen-BinGou Wen-FengFan Sai-JunLi Yi-Liang