GRIK5 Antibody (ARP37674_P050)
- Known as:
- GRIK5 Antibody (ARP37674_P050)
- Catalog number:
- arp37674_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- GRIK5 Antibody (ARP37674_P050)
Related genes to: GRIK5 Antibody (ARP37674_P050)
- Gene:
- GRIK5 NIH gene
- Name:
- glutamate ionotropic receptor kainate type subunit 5
- Previous symbol:
- GRIK2
- Synonyms:
- GluK5, KA2
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-21
- Date modifiied:
- 2016-02-05
Related products to: GRIK5 Antibody (ARP37674_P050)
Related articles to: GRIK5 Antibody (ARP37674_P050)
- Treatment-induced neuroendocrine prostate cancer (t-NEPC) is the major form of resistance to androgen receptor signaling inhibitors (ARSI) in advanced prostate cancer, characterized by pronounced invasiveness and lineage plasticity. Through in-depth analysis of prostate cancer cohorts, we found that glutamate ionotropic receptor kainate (GRIK) family members, specifically GRIK2 and GRIK5, are highly expressed in neural lineage plastic prostate cancer cells, NEPC patient-derived xenografts (PDX), and NEPC patient samples. Their expression positively correlates with neuroendocrine markers and inversely correlates with androgen receptor (AR) activity. Additionally, functional analyses indicated that AR has a direct transcriptional inhibitory effect on GRIK2 and GRIK5, and the absence of AR signaling leads to the upregulation of GRIK2 and GRIK5. Further RNA sequencing analysis revealed that GRIK5 silencing reprograms the cellular transcriptome, resulting in significant downregulation of AR signaling and fatty acid metabolism, while simultaneously activating immune and inflammatory responses in enzalutamide-resistant prostate cancer cells. In both cell line and NEPC PDX organoid models, loss of GRIK5 impaired proliferation and clonogenic growth. Notably, GRIK5 also contributes to enzalutamide resistance. Pharmacological evaluation revealed that Pan-GRIK antagonists exhibit anti-tumor activity, although the required relatively high concentrations suggest that more potent therapeutic strategies should be developed. Collectively, this study establishes that GRIK family members play critical roles in enzalutamide resistance and NEPC progression, highlighting GRIK signaling as a potential therapeutic target for overcoming lineage plasticity in prostate cancer. - Source: PubMed
Publication date: 2026/07/02
Qu HuanXu PengfeiYang Joy CWei FanZhao JunweiWang LeyiCorey EvaMitsiades NicholasLam KitIczkowski Kenneth ALi YuanpeiGao Allen CDall'Era MarcLiu Chengfei - Adolescent social isolation is a known risk factor for anxiety and depression related disorders, yet its effects on brain-gut communication and potential sex differences remain unclear. We hypothesised that isolation would heighten anxiety- and depression-related behaviors and consequently impair memory in both sexes. To investigate this we exposed male (M) and female (F) rats to four weeks of social isolation beginning at 3 weeks of age and assessed behavior, brain and gut gene expression and microbiota, in single- (S) or pair-housed (P) animals. Contrary to our hypothesis, the results showed higher novel object recognition memory in socially-isolated females (FS vs FP). No isolation-induced changes in anxiety-related behaviours were detected in either sex. Social isolation in females (FS vs FP) increased expression of hippocampal (glutamate receptor/memory/learning), and decreased expression of prefrontal cortex genes: , , (neuroplasticity), (neuroprotection) and (serotonin synthesis). There was a trend toward lower microbial diversity in socially-isolated females (FS vs FP). Although no behaviour change was detected in isolated males, amygdala c- (neuronal activity) and prefrontal cortex (inhibitory) expression were decreased. , , (immune-related) were increased in the colon (MS vs MP). In both sexes, social isolation increased expression in the colon (FS vs FP; MS vs MP). These findings indicate sex-specific responses to adolescent social isolation, with females showing enhanced novel object recognition memory performance alongside changes in genes linked to neuroplasticity and memory, while males showed altered brain and gut gene expression linked to brain neuro-activity and gut-immune function. - Source: PubMed
Publication date: 2026/06/08
Ahmad RaiseZobel GosiaHannaford RinaMaclean PaulOlson TrentHurst CharlotteBracegirdle JeremyYoung WayneRettedal ElizabethAnderson Rachel CDalziel Julie E - Hyperlipidaemia (HLP) arises from impaired lipid homeostasis in the setting of chronic low-grade inflammation, yet mechanistic comparisons between the edible medicinal fungi Cordyceps militaris and Ophiocordyceps sinensis remain scarce. Here, we combined chemical profiling with target/pathway prioritisation and structure-based modelling to define shared and species-specific lipid-regulatory features of these two fungi, followed by in vivo validation of cordycepin, a representative component of C. militaris, in high-fat diet (HFD)-fed mice. Integrated network analysis identified 72 common HLP-related targets, supporting convergence on inflammation-metabolism crosstalk. C. militaris displayed a more concentrated signature, characterised by GRIK family and proteasome-associated hubs and prominent enrichment of AMPK-related signalling. In contrast, O. sinensis was preferentially associated with upstream regulatory networks including insulin signalling, PI3K-Akt, MAPK and HIF-1. Molecular dynamics simulations showed relatively stable behaviour for the GRIK5-cordycepin and HCAR2-nicotinic acid complexes, whereas ERBB2-cerevisterol exhibited larger conformational fluctuation. MM-PBSA calculations further provided quantitative support for ligand-target association in the selected representative complexes. HPLC confirmed cordycepin as a characteristic component of C. militaris. In vivo, cordycepin improved fasting glucose and circulating lipid profiles, alleviated hepatic steatosis-like changes, and was accompanied by increased hepatic Prkaa1 and decreased Srebf1 expression. Collectively, these findings provide comparative computational insights into the hypolipidaemic potential of C. militaris and O. sinensis, while supporting cordycepin as a bioactive constituent of C. militaris associated with transcriptional changes related to AMPK/SREBP-1c signalling. The predicted regulatory features of O. sinensis still require direct experimental validation. - Source: PubMed
Publication date: 2026/05/09
Shi HuaijieZhang GuoyingLing Jianya - BACKGROUND: Autism spectrum disorder (ASD) is a genetically inherited, complex neuropsychiatric developmental condition that impacts a person's ability to learn, interact, and communicate. ASD is currently classified as a heterogeneous disorder, given that the pathophysiology of ASD is yet unknown. The GRIK gene family (GRIK1, GRIK2, GRIK3, GRIK4, and GRIK5) has genetic variants associated with many psychiatric illnesses including; depression, obsessive–compulsive disorder, and autism. The present study is the first to determine the possible association of GRIK1 rs363598 and intergenic rs360932 variants with susceptibility to ASD in Egyptian children and to correlate these variants with different parameters. SUBJECT AND METHODS: One hundred children with ASD and one hundred volunteer healthy children served as control group were enrolled. Clinical parameters were measured. The genotyping method was performed in all children using the Tetra-primer Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR) technique. RESULTS: ASD cases were mainly associated with males (77%) than females (23%) (p = 0.014) with lower IQ than the healthy group. The mean score on the Childhood Autism Rating Scale (CARS) was 39.40 ± 6.25. Interestingly, the genotype of the rs360932 SNP showed a significant difference in distribution between the ASD patients and the healthy control group (OR = 2.84, 95% CI = 1.29–6.35, P = 0.008); the genotype (AG) was substantially associated (90%) with ASD. Conversely, no discernible variation was seen in the distribution of the rs363598 SNP (OR = 3.19, 95% CI = 0.83–12.1, P = 0.07). Furthermore, the distribution of alleles for both variations did not differ significantly between the group of people with ASD and the healthy group. CONCLUSIONS: Egyptian children's increased risk of developing ASD is highly correlated with the rs360932 variation. Future research on other SNPs and genes linked to ASD may benefit from this study's increased chances of examining these topics. - Source: PubMed
Publication date: 2025/12/01
Bassiony HebaBaiomy AhmedAhmed DoaaElaraby Nesma MAmmar Tamer H AAshaat Engy A - It has been shown previously that repeated positive fighting experience in daily agonistic interactions is accompanied by the development of psychosis-like behavior, with signs of an addiction-like state associated with changes in the expression of genes encoding the proteins involved in the main neurotransmitter events in some brain regions of aggressive male mice. Fighting deprivation (a no-fight period of 2 weeks) causes a significant increase in their aggressiveness. This paper is aimed at studying-after a period of fighting deprivation-the involvement of genes (associated with neurotransmitter systems within the nucleus accumbens) in the above phenomena. The nucleus accumbens is known to participate in reward-related mechanisms of aggression. We found the following differentially expressed genes (DEGs), whose expression significantly differed from that in controls and/or mice with positive fighting experience in daily agonistic interactions followed by fighting deprivation: catecholaminergic genes , , , , , and ; serotonergic genes , , , and ; opioidergic genes , , and ; and glutamatergic genes , , , , , , , and . The expression of DEGs encoding proteins of the GABAergic system in experienced aggressive male mice mostly returned to control levels after fighting deprivation, except for . In light of the conceptual paradigm for analyzing data that was chosen in our study, the aforementioned DEGs associated with the behavioral pathology can be considered responsible for consequences of aggression followed by fighting deprivation, including mechanisms of an aggression relapse. - Source: PubMed
Publication date: 2025/09/03
Kudryavtseva Natalia NSmagin Dmitry ARedina Olga EKovalenko Irina LGalyamina Anna GBabenko Vladimir N