Gria1 antibody - N-terminal region (ARP37670_P050)
- Known as:
- Gria1 (anti-) - N-terminal region (ARP37670_P050)
- Catalog number:
- arp37670_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- Gria1 antibody - N-terminal region (ARP37670_P050)
Related genes to: Gria1 antibody - N-terminal region (ARP37670_P050)
- Gene:
- GRIA1 NIH gene
- Name:
- glutamate ionotropic receptor AMPA type subunit 1
- Previous symbol:
- GLUR1
- Synonyms:
- GluA1, GLURA
- Chromosome:
- 5q33.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-13
- Date modifiied:
- 2016-10-06
Related products to: Gria1 antibody - N-terminal region (ARP37670_P050)
Related articles to: Gria1 antibody - N-terminal region (ARP37670_P050)
- Glutamatergic neuron-to-glioma signaling mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) has emerged as an important mechanism in glioma progression. We analyzed the expression of the AMPAR subunit genes , , , and in lower-grade glioma (LGG). Expression of - was highest in IDH-mutant/1p19q-codeleted tumors and lowest in IDH-wildtype tumors across both The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) cohorts. High expression of each gene was associated with longer overall survival (OS). Transcriptome-wide analyses identified positive correlations between an AMPAR score and genes involved in synaptic organization, neuronal connectivity, and neurotransmission. Co-expression analyses demonstrated coordinated expression between - and genes encoding AMPAR auxiliary proteins. Gene Ontology (GO) enrichment revealed overrepresentation of synaptic signaling, trans-synaptic communication, and synapse organization. Although the AMPAR score was associated with favorable survival in univariate analyses, it did not retain independent prognostic significance after adjustment for key clinicomolecular variables. Elevated expression of AMPAR subunit genes in LGG was associated with favorable molecular subtypes and a synaptic transcriptional program. These findings suggest that - expression is associated with a synaptically enriched transcriptional program in LGG, although its cellular origin remains uncertain. - Source: PubMed
Publication date: 2026/07/23
Rodrigues BrunoDalmolin MatheusDal-Pizzol Henrique RitterMalafaia OsvaldoFernandes Marcelo A CCoelho Karina Munhoz de Paula AlvesRoesler RafaelIsolan Gustavo R - Immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of advanced non-small cell lung cancer (NSCLC), yet ~50% of lung adenocarcinoma (LUAD) patients exhibit primary or acquired resistance, underscoring the urgent need for predictive biomarkers. Hypoxia and metabolic reprogramming (HMR) are intertwined oncogenic hallmarks that reshape the tumor microenvironment (TME) and drive immune evasion, representing promising targets for signature development. Herein, we constructed an integrated HMR gene signature to predict clinical outcomes and therapeutic vulnerabilities in LUAD. - Source: PubMed
Publication date: 2026/06/25
Ma YuquanYang MengmengSun ZhitaoLiu FeiZheng BoyingWang YanweiLiu Junfeng - Schizophrenia is a complex mental disorder with an estimated heritability of 80%, yet its underlying pathophysiology remains poorly understood. Emerging evidence implicates the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) glutamate receptor-a key player in fast excitatory synaptic transmission, encoded by Glutamate Ionotropic Receptor AMPA Type Subunits 1-4 ()-in the disorder's pathophysiology. However, findings from postmortem brain samples regarding expression have been inconsistent. This study aimed to systematically evaluate the differential expression of genes in schizophrenia by integrating transcriptomic data from postmortem brain tissue and patient-derived cerebral organoids. - Source: PubMed
Publication date: 2026/05/21
Baumel AdanYitzhaky AssifHertzberg Libi - Previous studies indicate that dental anxiety (DA) is associated with increased salivary cortisol and alpha-amylase, biomarkers of hypothalamic-pituitary-adrenal (HPA) axis and sympathetic-adrenal-medullary (SAM) activation. However, underlying molecular mechanisms remain unclear. This study aimed to explore whether peripheral blood mRNA expression levels of glucocorticoid receptor (GR), GR transcripts containing exons 1B (GR-1B), glutamate ionotropic receptor AMPA type subunit 1 (GRIA1), oxytocin (OT), oxytocin receptor (OTR), and Poly ADP-Ribose Polymerase 1 (PARP1), together with salivary cortisol and alpha-amylase levels, are associated with dental anxiety. - Source: PubMed
Publication date: 2026/07/01
Wenlong LiuHuai TaoShichen WangChao LiuXianggang HouHongshuang ZhuYige DuanMinghai BaiYong Liu - Brain dysfunction is a primary symptom of Gulf War illness (GWI). The present study investigated the effects of an amorphous formula of curcumin (CUR) and α-glycosyl isoquercitrin (AGIQ) on neurobehaviors and adult neurogenesis and following synaptic plasticity of produced neurons in the hippocampal dentate gyrus (DG) in a rat GWI model. Ten-week-old rats received GWI-related chemicals and restraint stress for 28 days; thereafter, animals were fed either a diet without supplement or mixed with 0.1% CUR or 0.5% AGIQ for 126 days. GWI treatment adversely affected behavioral endpoints, including novel object recognition, sucrose preference, novelty-suppressed feeding, and contextual fear conditioning. CUR ameliorated all these effects, while AGIQ caused anxiety-like behavior and improved fear extinction learning. GWI treatment downregulated NRF2-KEAP1 pathway-related genes in the DG; both phytochemicals reversed most of these changes. GWI treatment increased CD68 and CD163 microglia populations in the DG hilus; both phytochemicals reversed the increase of CD68 microglia. In the neurogenic niche, GWI treatment decreased GFAP neural stem cells but increased DCX and PCNA cells, decreased hilar SST and GAD67 GABAergic interneurons, and downregulated Pvalb. CUR reversed decreases in GFAP cell and SST interneuron numbers. Both phytochemicals increased VGLUT1 immunoreactivity, restored the VGLUT1/VGAT ratio, and upregulated Bdnf, Gria1, Gria2, Gria3, Slc17a7, Ptgs2, and Mapk1. AGIQ further increased COX2 cell numbers and upregulated Grin2a, Grin2b, and Mapk3. In summary, both phytochemicals may have exerted antioxidant effects and modulated excitatory/inhibitory balance via glutamatergic signaling in GWI animals; CUR was superior to AGIQ at normalizing aberrant neurobehaviors and neurogenesis. - Source: PubMed
Publication date: 2026/06/25
Tang QianShobudani MomokaSakamaki YuriEbizuka YuriZou XinyuKobayashi MioKigata TetsuhitoKoyanagi MihokoNakao TomohiroShibutani Makoto