MCM7 Antibody - N-terminal region (ARP36693_P050)
- Known as:
- MCM7 Antibody - N-terminal region (ARP36693_P050)
- Catalog number:
- arp36693_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- MCM7 Antibody - N-terminal region (ARP36693_P050)
Related genes to: MCM7 Antibody - N-terminal region (ARP36693_P050)
- Gene:
- MCM7 NIH gene
- Name:
- minichromosome maintenance complex component 7
- Previous symbol:
- MCM2
- Synonyms:
- CDC47, PPP1R104
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-13
- Date modifiied:
- 2016-10-05
Related products to: MCM7 Antibody - N-terminal region (ARP36693_P050)
Related articles to: MCM7 Antibody - N-terminal region (ARP36693_P050)
- Hepatocellular carcinoma (HCC) exhibits profound molecular heterogeneity and aberrant cellular senescence. This study systematically dissects the senescence-associated molecular landscape to identify key regulators driving HCC progression and immune evasion. - Source: PubMed
Publication date: 2026/05/08
Tuergan TalaitiAbulaiti AimitajiYilihaer YierfanLiu BingweiShao YingmeiJiang TieminAji Tuerganaili - The overexpression of the MCM-7 gene, a key player in the minichromosomal maintenance complex critical for DNA replication initiation, is linked to various aggressive cancers. Despite MCM-7's importance in cancer therapy, its amino acid structure has only recently been elucidated, and no clinical trials with small molecular antagonists have been pursued. The present study highlights the anticancer potential of vitamins D2, D3, and K2-loaded keratin nanoparticles, exploring a novel approach to cancer treatment. We found that NPD3 and NPK2 have more anti-proliferative effects than NPD2 through rigorous in-vitro assays utilizing the MCF-7 human breast cancer cell line, known for MCM-7 overexpression. Mechanistically, NPD3 exerts its anticancer effect by downregulating MCM-7 protein expression, while NPK2 induces intracellular ROS generation. The study involves a nanocarrier system derived from human hair keratin, enhancing the bioavailability and efficacy of these vitamins. These nanocarriers not only improve the anti-proliferative effects of the vitamins but also demonstrated exceptional biocompatibility and controlled drug release in response to pH changes. These findings propose a novel, commercially viable delivery system for water-insoluble vitamins, offering a promising therapeutic avenue against cancers with MCM-7 overexpression. - Source: PubMed
Publication date: 2026/05/04
Mukherjee SunnyBhavya KumariDan SiddharthaPal DurbaSah Mahesh Kumar - Intraorganismal genetic heterogeneity (IGH) arises from the accumulation of somatic mutations during plant growth. Although leaves of exhibit pronounced IGH, its molecular basis remains unclear. Under strictly controlled growth conditions, this study compared a wild population (LC-W) with the cultivated cultivar Zhongke No. 2 (LC-ZK2) to search for DNA repair-related clues associated with leaf nuclear DNA diversity. Genomic DNA amplification and Sanger sequencing of three nuclear loci (, , and ) showed that, compared with LC-W, LC-ZK2 exhibited fewer polymorphic sites and lower haplotype diversity, indicating a more restricted leaf-scale sequence heterogeneity. leaf transcriptome analysis identified 3,833 differentially expressed genes (DEGs; |logFC| ≥ 1, FDR < 0.05; logFC = log[LC-W/LC-ZK2]). GO and KEGG analyses indicated that DEGs were significantly enriched in DNA damage response and DNA repair pathways, with particularly prominent enrichment of base excision repair (BER) and homologous recombination (HR). The BER scaffold gene plays an important role in these pathways and was significantly upregulated in LC-ZK2 (~2.6-fold), suggesting transcriptional differences in repair-related genes between the two materials. Further Sanger sequencing of the BRCT domain indicated that LC-ZK2 possessed a more concentrated haplotype spectrum and exhibited distinct amino acid substitution combinations, providing candidate sites for subsequent functional validation. Overall, this study links differences in nuclear DNA diversity with repair-associated transcriptomic signatures and provides an interpretive framework for understanding leaf-scale heterogeneity divergence in . - Source: PubMed
Publication date: 2026/04/10
Yu HaoyangWang XinxiaNaren GaowaHao RiqingShi HuihuiMa ShumengZhang Lingang - The inference of molecular information from hematoxylin-eosin (HE) specimens may reduce the ancillary testing burden in digital pathology. - Source: PubMed
Publication date: 2026/04/25
Urata TakumiTakeyama SaoriKimura FumikazuOhshima KengoIshii KeikoJi CunyuanTakagi GenYamaguchi Masahiro - - Source: PubMed
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