ZNF771 antibody - N-terminal region (ARP35926_P050)
- Known as:
- ZNF771 (anti-) - N-terminal region (ARP35926_P050)
- Catalog number:
- arp35926_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF771 antibody - N-terminal region (ARP35926_P050)
Related genes to: ZNF771 antibody - N-terminal region (ARP35926_P050)
- Gene:
- ZNF771 NIH gene
- Name:
- zinc finger protein 771
- Previous symbol:
- -
- Synonyms:
- DSC43
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-14
- Date modifiied:
- 2016-01-14
Related products to: ZNF771 antibody - N-terminal region (ARP35926_P050)
Related articles to: ZNF771 antibody - N-terminal region (ARP35926_P050)
- The formation of subendothelial macrophage-derived foam cells is a key driver of atherogenesis and contributes to the onset and progression of atherosclerosis (AS). The METTL3 gene, a central mediator of N6-methyladenosine (m6A) RNA methylation, serves as a critical regulatory node at the inflammation-metabolism nexus in immune pathophysiology. - Source: PubMed
Publication date: 2026/01/14
Tu Yi-FuLi YuanQin Jin-FengChen Wan-YiZhu XiaoSammad AbdulYin Kai - Previous studies have revealed that transcription factors (TFs) play important roles in biparental (BI) early human embryogenesis. However, the contribution of TFs during early uniparental embryo development is still largely unknown. Here we systematically studied the expression profiles of transcription factors in early embryonic development and revealed the dynamic changes of TFs in human biparental and uniparental embryogenesis by single-cell RNA sequencing (scRNA-seq). In general, the TF expression model of uniparental embryos showed a high degree of conformity with biparental embryos. The detailed network analysis of three different types of embryos identified that 10 out of 17 hub TFs were shared or specifically owned, such as ZNF480, ZNF581, PHB, and POU5F1, were four shared TFs, ZFN534, GTF3A, ZNF771, TEAD4, and LIN28A, were androgenic (AG) specific TFs, and ZFP42 was the only one parthenogenetic (PG) specific TF. All the four shared TFs were validated using human embryonic stem cell (hESC) differentiation experiments; most of their target genes are responsible for stem cell maintenance and differentiation. We also found that Zf-C2H2, HMG, and MYB were three dominant transcription factor families that appeared in early embryogenesis. Altogether, our work provides a comprehensive regulatory framework and better understanding of TF function in human biparental and uniparental embryogenesis. - Source: PubMed
Publication date: 2021/09/17
Zhang ChenxiLi ConghuiYang LingLeng LizhiJovic DragomirkaWang JunFang FangLi GuiboZhao DepengLi XuemeiLin LinLuo YonglunBolund LarsHuang JinrongLin GeXu Fengping - Study of epigenetics is currently a high-impact research topic. Multi stage methylation is also an area of high-dimensional prospect. In this article, we provide a new study (intra and inter-species study) on brain tissue between human and rhesus on two methylation cytosine variants based data-profiles (viz., 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) samples) through TF-miRNA-gene network based module detection. - Source: PubMed
Publication date: 2018/01/22
Maulik UjjwalSen SagnikMallik SauravBandyopadhyay Sanghamitra - Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (P = 1.31 × 10) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a clinical index for obesity in children, adolescents, and adults. These sites were also associated with multiple metabolic syndrome (MetS) traits, including central obesity, fat depots, insulin responsiveness, and plasma lipids. The SOCS3 methylation locus was also associated with the clinical definition of MetS. In the validation cohort, SOCS3 methylation status was found to be inversely associated with BMI% (P = 1.75 × 10), waist to height ratio (P = 4.18 × 10), triglycerides (P = 4.01 × 10), and MetS (P = 4.01 × 10), and positively correlated with HDL-c (P = 4.57 × 10). Functional analysis in a sub cohort (333 individuals) demonstrated SOCS3 methylation and gene expression in PBMCs were inversely correlated (P = 2.93 × 10) and expression of SOCS3 was positively correlated with status of MetS (P = 0.012). We conclude that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS. - Source: PubMed
Publication date: 2016/08/26
Ali OmarCerjak DianaKent Jack WJames RolandBlangero JohnCarless Melanie AZhang Yi