ZNF224 antibody - middle region (ARP35873_P050)
- Known as:
- ZNF224 (anti-) - middle region (ARP35873_P050)
- Catalog number:
- arp35873_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF224 antibody - middle region (ARP35873_P050)
Related genes to: ZNF224 antibody - middle region (ARP35873_P050)
- Gene:
- ZNF224 NIH gene
- Name:
- zinc finger protein 224
- Previous symbol:
- ZNF255, ZNF27
- Synonyms:
- BMZF-2, KOX22
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-08-13
- Date modifiied:
- 2015-09-09
Related products to: ZNF224 antibody - middle region (ARP35873_P050)
Related articles to: ZNF224 antibody - middle region (ARP35873_P050)
- - Source: PubMed
Publication date: 2026/03/27
- Expression of zinc finger protein 224 (ZNF224) is deregulated in various hematological and solid cancers, where its high protein levels correlate well with faster progression and worse prognosis due to activation of oncogenic pathways involved in promoting cell growth and survival, inhibiting apoptosis, and sustaining invasion and metastasis. In previous works, we identified ZNF224 as one of the mediators of the transforming growth factor beta (TGF-β)-induced pro-tumoral activities in melanoma. In the present study, we thoroughly investigated the molecular mechanisms underlying the oncogenic role of ZNF224 in this kind of cancer. We demonstrated that ZNF224 overexpression caused increased cell growth and reduced drug-mediated apoptosis by enhancing the dysregulated function of cyclin-dependent kinase inhibitor 1 [p21(CIP1/WAF1), also known as CDKN1A]. We provide strong evidence that ZNF224 overexpression in melanoma cell lines positively modulated p21(CIP1/WAF1) gene transcription in a p53-dependent manner and enhanced AKT-triggered p21(CIP1/WAF1) oncogenic effects through its protein cytosolic retention, inhibiting apoptosis and favoring cell proliferation. Analysis of transcriptomic data from human melanoma tissue samples confirmed a close relationship between p21(CIP1/WAF1) and ZNF224 in cells, at least as long as p53 functionality is maintained. The tumorigenic molecular mechanism involving ZNF224, identified in this study, provides new insights into understanding melanoma development and progression, breaking ground in the research for new therapeutic tools. - Source: PubMed
Publication date: 2025/05/05
Sepe LeandraCandia UmbertoSasso Del Verme DarioToscano ElviraToriello MariannaSodaro GaetanoRapuano RobertaRomano SimonaGrosso MichelaPaolella GiovanniLupo AngeloCostanzo PaolaCesaro Elena - Ionizing radiation (IR) exposure poses a significant health risk due to its widespread use in medical diagnostics and therapeutic applications, necessitating rapid and effective biomarkers for assessment. - Source: PubMed
Publication date: 2025/03/17
Zebene Emeshaw DamtewPucci BiagioLombardi RitaMedhin Hagos TesfaySeife EdomDi Gennaro ElenaBudillon AlfredoWoldemichael Gurja Belay - Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, whose presentation and clinical course are highly variable. Identification of novel prognostic factors may contribute to improving the CLL classification and providing indications for treatment options. The zinc finger protein ZNF224 plays a key role in cell transformation, through the control of apoptotic and survival pathways. In this study, we evaluated the potential application of ZNF224 as a novel marker of CLL progression and therapy responsiveness. To this aim, we analyzed ZNF224 expression levels in B lymphocytes from CLL patients at different stages of the disease and in patients showing different treatment outcomes. The expression of ZNF224 was significantly increased in disease progression and dramatically decreased in patients in complete remission after chemotherapy. Gene expression correlation analysis performed on datasets of CLL patients revealed that ZNF224 expression was well correlated with that of some prognostic and predictive markers. Moreover, bioinformatic analysis coupled ZNF224 to NF-κB pathway, and experimental data demonstrated that RNA interference of ZNF224 reduced the activity of the NF-κB survival pathway in CLL cells. Consistently with a pro-survival role, ZNF224 knockdown raised spontaneous and drug-induced apoptosis and inhibited the proliferation of peripheral blood mononuclear cells from CLL patients. Our findings provide evidence for the involvement of ZNF224 in the survival of CLL cells NF-κB pathway modulation, and also suggest ZNF224 as a prognostic and predictive molecular marker of CLL disease. - Source: PubMed
Publication date: 2022/11/09
Catapano RosaSepe LeandraToscano ElviraPaolella GiovanniChiurazzi FedericoBarbato Serafina PatriziaBruzzese DarioArianna RosaGrosso MichelaRomano SimonaRomano Maria FiammettaCostanzo PaolaCesaro Elena - Zinc finger protein family is the largest transcription factor family in the human genome. Studies have shown that the aberrant expression of zinc finger protein (ZNF) had a potential role in tumorigenesis. However, due to the high complexity of the ZNF family genes, the role of the ZNF family genes in breast cancer (BRCA) is still lacking in systematic understanding. - Source: PubMed
Publication date: 2022/04/02
An GailiFeng LuHou LeiLi XuBai JunHe LiGu ShanzhiZhao Xinhan