ZNF146 antibody - middle region (ARP35828_P050)
- Known as:
- ZNF146 (anti-) - middle region (ARP35828_P050)
- Catalog number:
- arp35828_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF146 antibody - middle region (ARP35828_P050)
Related genes to: ZNF146 antibody - middle region (ARP35828_P050)
- Gene:
- ZNF146 NIH gene
- Name:
- zinc finger protein 146
- Previous symbol:
- -
- Synonyms:
- OZF
- Chromosome:
- 19q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-01
- Date modifiied:
- 2014-11-19
Related products to: ZNF146 antibody - middle region (ARP35828_P050)
Related articles to: ZNF146 antibody - middle region (ARP35828_P050)
- This study aimed to investigate the role of ZNF146 in osteosarcoma progression and its potential as a therapeutic target and prognostic biomarker, focusing on its interaction with the HMGB1-NF-κB signaling pathway. - Source: PubMed
Publication date: 2025/12/24
Yang RuiFeng HuLi ShengXu ShenglinWang QianxiWang HaoXiao LongzeHu Yong - Lung adenocarcinoma (LUAD) remains a significant contributor to cancer incidence and mortality, with transcription factors playing pivotal roles in its progression and serving as potential therapeutic targets. - Source: PubMed
Publication date: 2025/06/28
Zhu JunkanRen ShenchengYi YanjunWu ZhiyaoLin HanShan GuangyaoHuang XiaolongPan BinyangHu ZhengyangSui QihaiZhan ChengWang ShuaiLiang Jiaqi - Aberration in cell cycle progression is one of the essential mechanisms underlying tumorigenesis, making regulators of cell cycle reasonable anti-cancer therapeutic targets. Here, we dissected the regulatory mechanism involving the novel axis ZNF146/TFDP1/DEPDC1B in the cell cycle in ovarian cancer. - Source: PubMed
Publication date: 2024/05/31
Zhao RuixueSong NanaNing XinChen XihaiMa Rong - Long noncoding RNAs (lncRNAs) have been implicated in tumorigenesis, including lung adenocarcinoma (LUAD). However, the functional and regulatory mechanisms of lncRNAs in LUAD remain poorly understood. In this study, we investigated the role of lncRNA ZBED5-AS1 in LUAD. We found that ZBED5-AS1 was upregulated in LUAD specimens and overexpressed in LUAD cell lines. ZBED5-AS1 promoted LUAD cell proliferation, migration, and invasion in vitro and promoted LUAD cell growth in vivo. ZBED5-AS1 promoted ZNF146 expression, activating the ATR/Chk1 pathway and leading to LUAD progression. We observed that exosomes from LUAD cells have a higher expression of ZBED5-AS1 compared with exosomes from the normal cell line BEAS-2B. Coculture experiments with exosomes showed that ZBED5-AS1 expression was downregulated after coculture with Si-ZBED5-AS1 exosomes, and coculture with exosomes with low ZBED5-AS1 expression inhibited proliferation and invasion of LUAD cells. Our results indicate that ZBED5-AS1 functions as an oncogenic factor in LUAD cells by targeting the ZNF146/ATR/Chk1 axis. - Source: PubMed
Publication date: 2023/09/10
Jiang FengHuang XiaoluLing LiqunTang ShiyiZhou HuixinCai XuedingWang Yumin - Hepatocellular carcinoma (HCC) is the most common type of liver malignancy with high incidence and poor prognosis. Transmembrane protein 147 (TMEM147) has been implicated in the development of colon cancer. However, the role of TMEM147 in HCC remains unclear. In this study, data of 371 HCC tissues, 50 adjacent nontumor tissues, and 110 normal liver tissues were retrieved from the TCGA and GTEx databases. TMEM147 expression was found to be increased in HCC tissues. High expression of TMEM147 was related to poor prognosis, and TMEM147 was confirmed to be an independent prognostic factor for HCC patients. A receiver operating characteristics (ROC) analysis was performed and showed that the diagnostic efficacy of TMEM147 was significantly higher than that of AFP (0.908 versus 0.746, p < 0.001). Furthermore, TMEM147 promoted tumor immune infiltration, and macrophages were the immune cells that predominantly expressed TMEM147 in HCC. Further analysis revealed that TMEM147 mainly impacted the ribosome pathway, and CTCF, MLLT1, TGIF2, ZNF146, and ZNF580 were predicted to be the upstream transcription factors for TMEM147 in HCC. These results suggest that TMEM147 serves as a promising biomarker for diagnosis and prognosis and may potentially become a therapeutic target for HCC. - Source: PubMed
Publication date: 2023/06/16
Fan Wen-JieZhou Meng-XiWang Di-DiJiang Xin-XinDing Hao