ZNF197 antibody - N-terminal region (ARP35820_P050)
- Known as:
- ZNF197 (anti-) - N-terminal region (ARP35820_P050)
- Catalog number:
- arp35820_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF197 antibody - N-terminal region (ARP35820_P050)
Related genes to: ZNF197 antibody - N-terminal region (ARP35820_P050)
- Gene:
- ZNF197 NIH gene
- Name:
- zinc finger protein 197
- Previous symbol:
- ZNF166
- Synonyms:
- P18, D3S1363E, ZKSCAN9, ZSCAN41
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-29
- Date modifiied:
- 2016-10-05
Related products to: ZNF197 antibody - N-terminal region (ARP35820_P050)
Related articles to: ZNF197 antibody - N-terminal region (ARP35820_P050)
- This study investigates the role of the long noncoding RNA (lncRNA) in uveal melanoma (UM), focusing on its function within a competing endogenous RNA (ceRNA) network. Using the UM-related TCGA (The Cancer Genome Atlas) dataset, we analyzed the expression levels of and its correlation with and , an essential autophagy-related gene. Our analysis revealed that acts as a ceRNA by competitively binding to , resulting in the upregulation of . This interaction plays a crucial role in the growth and metastasis of UM. The expression of showed a strong correlation with the clinical outcomes of patients with UM. Furthermore, in vitro assays confirmed that impedes UM cell proliferation, migration, and invasion by modulating the axis. These findings suggest that ZNF197-AS1 can effectively inhibit UM progression through this ceRNA regulatory network. This study provides valuable insights into the molecular mechanisms underlying UM and highlights the potential of targeting the axis as a therapeutic strategy for UM. This study identifies the ZNF197-AS1/miR-425/GABARAPL1 axis as a novel regulatory mechanism in uveal melanoma. ZNF197-AS1 upregulates GABARAPL1 by sponging miR-425, inhibiting UM cell proliferation, migration, and invasion. This discovery highlights a potential therapeutic target, providing new insights into UM progression and patient outcomes. - Source: PubMed
Publication date: 2024/09/23
Zhang ChaoWu Shuai - Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive tract, which accounts for 10% of all the malignant tumors in the world. The aim of this study was to identify key genes and miRNAs in CRC diagnosis, prognosis, and therapy and to further explore the potential molecular mechanisms of CRC. - Source: PubMed
Publication date: 2020/07/07
Wang LiangYang JunHuang JianWen Zheng-QiXu NingLiu XuanZhang Jian-HuaLi Wen-Liang - Copper is an essential trace nutrient and an enzymatic cofactor necessary for diverse physiological and biological processes. Copper metabolism is uniquely controlled in the placenta and changes to copper metabolism have been linked with adverse birth outcomes. We investigated associations between patterns of DNA methylation (DNAm; measured at >485 k CpG sites) and copper concentration measured from placentae in two independent mother-infant cohorts: the New Hampshire Birth Cohort Study (NHBCS, n = 306) and the Rhode Island Child Health Study (RICHS, n = 141). We identified nine copper-associated differentially methylated regions (DMRs; adjusted P < 0.05) and 15 suggestive CpGs (raw P < 1e-5). One of the most robust variably methylated CpGs associated with the expression of the antioxidant, GSTP1. Our most robust DMR negatively associates with the expression of the zinc-finger gene, (FDR = 4.5e-11). Genes co-expressed with , a transcription factor, are enriched for genes that associate with birth weight in RICHS (OR = 2.9, P = 2.6e-6, N = 194), genes that are near a ZNF197 consensus binding motif (OR = 1.34, P = 0.01, N = 194), and for those classified in GO biological processes (P = 3.4e-4), (P = 3.8e-4), and (P = 1.9e-4). Further, putative transcriptional targets for ZNF197 include genes involved in copper metabolism and placentation. Our results suggest that copper metabolism is tied to DNAm in the placenta and that copper-associated patterns in DNAm may mediate normal placentation and foetal development. - Source: PubMed
Publication date: 2019/09/04
Kennedy ElizabethEverson Todd MPunshon TracyJackson Brian PHao KeLambertini LucaChen JiaKaragas Margaret RMarsit Carmen J - The von Hippel-Lindau tumor suppressor (pVHL) is a component of an E3 ubiquitin ligase and targets hypoxia-inducible factor-1alpha (HIF-1alpha) for ubiquitylation and degradation under normoxic conditions. pVHL also directly inhibits HIF-1alpha transactivation by recruiting histone deacetylases. Here, we report a novel pVHL-interacting protein that functions as a negative regulator of HIF-1alpha transactivation. This protein, generated from the ZnF197 locus by alternative splicing, contains a Kruppel-associated box (KRAB)-A domain and a SCAN domain, but lacks the 22 C2H2-type zinc fingers present in ZnF197. Therefore, we named this protein pVHL-associated KRAB-A domain-containing protein (VHLaK). We demonstrate that the KRAB-A domain in VHLaK mediates pVHL binding and functions as a transcriptional repression module. The SCAN domain mediates VHLaK homo-oligomerization, which enhances VHLaK repressive activity. pVHL can recruit VHLaK to repress HIF-1alpha transcriptional activity and HIF-1alpha-induced VEGF expression. Finally, we demonstrate that pVHL, VHLaK and KAP1/TIF-1beta can be recruited into a single complex, indicating that KAP1/TIF-1beta may participate in pVHL-mediated transcriptional repression of HIF-1alpha. Our findings provide a novel mechanism for the modulation of HIF-1alpha transactivation by pVHL. - Source: PubMed
Li ZaiboWang DakunNa XiSchoen Susan RMessing Edward MWu Guan