THRB antibody - N-terminal region (ARP35636_P050)
- Known as:
- THRB (anti-) - N-terminal region (ARP35636_P050)
- Catalog number:
- arp35636_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- THRB antibody - N-terminal region (ARP35636_P050)
Related genes to: THRB antibody - N-terminal region (ARP35636_P050)
- Gene:
- THRB NIH gene
- Name:
- thyroid hormone receptor beta
- Previous symbol:
- ERBA2, PRTH
- Synonyms:
- THRB1, THRB2, NR1A2, THR1, ERBA-BETA, GRTH
- Chromosome:
- 3p24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-31
- Date modifiied:
- 2016-02-23
Related products to: THRB antibody - N-terminal region (ARP35636_P050)
Related articles to: THRB antibody - N-terminal region (ARP35636_P050)
- Calcification often occurs as a characteristic pathological manifestation in the progression of atherosclerosis (AS) plaques, but its mechanism is not fully understood yet. The purpose of this research was to supplement the exploration of key candidate genes and key cells involved in the calcification process of AS, building on existing insights into its underlying mechanisms. Through the examination of our internally generated single‑cell RNA sequencing (scRNA-seq) dataset derived from human carotid plaque samples, pivotal cellular populations associated with AS calcification were successfully identified. Following this identification, a comprehensive analytical approach was employed, incorporating differential gene expression profiling alongside the establishment of protein-protein interaction (PPI) networks, thereby enabling the extraction of critical genetic markers within these cellular subsets. Furthermore, a molecular regulatory framework was assembled, aiming to elucidate the mechanistic pathways through which these genetic determinants contribute to the calcification phenomena in AS pathology. Moreover, analysis of cell communication was applied to explore the interactions among cells. Pseudo-time analysis was employed to explore the expression of key candidate genes during the differentiation of key cells. Finally, monocytes were identified as key cells. WARS1, IFITM1, ANXA1, ADGRE2, and S100P were identified as key candidate genes. Moreover, 115 transcription factors such as THRB and 118 miRNAs such as hsa-miR-196a-5p were predicted to be associated with the key candidate genes. Across both calcified and non-calcified control specimens, the cellular communication between endothelial cells and natural killer (NK) T cell populations was consistently orchestrated via the PPBP-CXCR2 signaling axis. During monocytic differentiation trajectories, ADGRE2 expression exhibited a biphasic pattern characterized by initial gradual elevation followed by subsequent decline. Conversely, both ANXA1 and S100P demonstrated progressive upregulation throughout the differentiation process. The expression of IFITM1 and WARS1 first decreased, then increased, and finally decreased again. The present investigation successfully pinpointed five critical genes alongside one key cellular population, collectively providing potential molecular insights and candidate targets for further investigation into AS calcification. - Source: PubMed
Publication date: 2026/08/11
Yuan Huai WuWang WeiyeCheng WeiWang HongzheSong BoyanChen Tian XiangPeng Guo Ping - Amphibian organ culture is invaluable for gaining insight into thyroid hormone (TH) action. The olfactory epithelium (OE) of Rana (aka Aquarana or Lithobates) catesbeiana tadpoles is a highly TH-sensitive tissue that regulates essential survival behaviors and undergoes drastic remodeling during TH-dependent metamorphosis. These features make it a valuable bioindicator for normal and disrupted TH action. To our knowledge, we developed and validated the first successful ex vivo culture method for anuran tadpole olfactory epithelium. Pairs of OE-containing principal cavities from premetamorphic tadpoles were excised, each cavity cut in half, and exposed to 10 nM 3,5,3'-triiodothyronine (T) or solvent control at 24 °C for 24 h. Each half cavity showed consistent enrichment of the olfactory marker omp compared to back skin. Robust and reproducible TH responses were observed in individual, unpooled cultured olfactory epithelium (C-OE) as measured by reverse transcription-quantitative polymerase chain reaction of TH-responsive transcripts thra, thrb, and thibz. No spatial variation in hormone sensitivity within the principal cavity was observed supporting the use of repeated-measures statistics while capturing biological variation between animals. To probe early TH signaling events, C-OE and cultured back skin (C-skin) were treated with T in the presence of transcriptional and translational inhibitors at 24 °C or 4 °C. The cold condition represents a metamorphic stasis period during which the TH signal is initiated, but metamorphosis does not proceed. Notably, TH-induction of thibz at 4 °C was unaffected by transcriptional inhibition in both tissues, suggesting that mechanisms other than RNA synthesis may be driving the increase in transcript abundance. - Source: PubMed
Publication date: 2026/08/04
Field Emma MHelbing Caren C - Resistance to thyroid hormone β is a rare condition that causes decreased sensitivity to thyroid hormones in target tissues. We present the case of a young female diagnosed with a heterozygous missense mutation in the THRB gene, focusing on diagnosis, management, and preventing potential complications. - Source: PubMed
Publication date: 2026/02/21
Vargas Valerie MartinezDwivedi SaniyaPenquite Sara Ashlyn - Biological age (BA) has emerged as a promising integrative indicator of physiological state and welfare, but its use within aquaculture remains underdeveloped. Previous genome-wide analysis in gilthead sea bream revealed skeletal muscle markers with inverse age-related expression and methylation patterns. Specifically, psmd2, ramp1, sirt1 and smad1 were up-regulated and hypomethylated with age, while atp1a2, bmp1, calcrl, col5a1, spred2 and thrb exhibited down-regulation coupled with hypermethylation. Here we assessed the responsiveness of this gene set across multiple aquaculture-relevant challenges using a real-time PCR array. Environmental stressors (e.g. increased temperature and high stocking density with low O concentration) induced transcriptional profiles resembling muscle gene-expression patterns of older individuals. Conversely, cold exposure and nutritional interventions, including restricted feeding and feed supplementation with bioactive protein hydrolysates, microalgae meal with a PUFA-rich lipid source, or fat emulsifiers promoted signatures aligned with those observed in younger animals. Although the direct reversal of stress-induced aging signatures was not tested, results indicate that dietary interventions elicit opposing transcriptional patterns, highlighting potential strategies to mitigate environmentally mediated aquaculture stress through targeted nutrition. These findings provide preliminary evidence of a potential relationship between BA and aquaculture stressors in farmed fish, underpinning a genomics-based framework for welfare assessment and adaptive management. - Source: PubMed
Publication date: 2026/07/09
Naya-Català FernandoGasperini AliceCarbonero-Acín BeatrizCalduch-Giner JosepBelenguer ÁlvaroPérez-Sánchez Jaume - High-latitude populations represent valuable case studies to investigate the genetic bases of human biological adaptations to cold climates. Nevertheless, by relying on traditional natural selection models, a limited fraction of them was identified. To overcome this issue, we integrate diverse inferential methods in the attempt to pinpoint combinations of genes presenting both selection signatures and functional relationships supporting their synergic role in regulating a biological trait, as expected under polygenic adaptation. We analyze Yakut genomes from Northeastern Siberia and Russian ones, pointing to adaptive evolution at genes contributing to functions modulated during cold exposure, such as thyroid hormone/insulin signalling (THRB, RCAN2, INSR, NFKB1), brown adipose tissue differentiation (ERBB4) and glycerolipid metabolism (GPAT3). Concerted changes at these loci may support enhanced heat production and responsiveness to insulin, having been partly influenced also by Neanderthal introgression, and provide suggestive insights into the complex adaptations that enabled Eurasians' ancestors to colonize cold environments. - Source: PubMed
Publication date: 2026/06/23
Ferraretti GiuliaAlberti MartaCicolini RositaPognant Viù SabrinaSarno StefaniaSazzini Marco