CATSPER2 antibody - C-terminal region (ARP35452_T100)
- Known as:
- CATSPER2 (anti-) - C-terminal region (ARP35452_T100)
- Catalog number:
- arp35452_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CATSPER2 antibody - C-terminal region (ARP35452_T100)
Related genes to: CATSPER2 antibody - C-terminal region (ARP35452_T100)
- Gene:
- CATSPER2 NIH gene
- Name:
- cation channel sperm associated 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-06-20
- Date modifiied:
- 2016-02-04
Related products to: CATSPER2 antibody - C-terminal region (ARP35452_T100)
Related articles to: CATSPER2 antibody - C-terminal region (ARP35452_T100)
- This study aimed to investigate the effectiveness of intraepididymal platelet-rich plasma (PRP) administration in preventing cryopreservation-induced sperm damage in rams. Twelve adult rams were randomly assigned into two groups ( = 6) in the non-breeding season. Rams in the PRP group received 0.2 ml/per epididymis (150–200 × 10⁶ platelets) of PRP every 15 days for a total of six injections, while control group received the same volume of saline. Semen samples were collected biweekly and pooled within each group before undergoing standard cryopreservation procedures. Post-thaw analyses included morphological, functional, biochemical, and molecular assessments. Compared to the control, intraepididimal PRP significantly increased hypo-osmotic swelling (HOS) response, total and progressive motility, rapid sperm percentage, and kinetic parameters (VCL- curvilinear velocity, VSL- straight-line velocity, VAP- average path velocity), while reducing static and acrosome-damaged sperm in thawed semen. Intraepididimal PRP also enhanced catalase activity, cholesterol and myristic acid (C14:0) concentrations and the levels of steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase type 1 (HSD3β1), cation channel of sperm (CatSper1), platelet-derived growth factor (PDGF), platelet-derived growth factor receptor (PDGFR), and reduced malondialdehyde level in thawed semen. Intraepididimal PRP significantly increased the mRNA presence of CatSper2, CatSper3, CatSper4, transient receptor potential melastatin 3 (TRPM3) and transient receptor potential vanilloid 5 (TRPV5) ion channels, oar-miR-3958-3p and oar-miR-125b, and decreased bta-miR-22-3p and rno-miR-494 in thawed semen. Additionally, intraepididimal PRP significantly upregulated the protein expressions of CatSper3, HSD3β2 and PDGFA, and decreased protein expressions of vascular endothelial growth factor A (VEGFA) and transforming growth factor beta 1 (TGFβ1) in thawed semen. In conclusion, intraepididymal PRP administration improved cryoresistance in ram spermatozoa, likely due to its growth factors, lipids, and antioxidants. These effects enhanced post-thaw sperm quality by modulating oxidative stress, cholesterol, ion channels, microRNAs, and steroidogenic proteins, indicating PRP as a promising tool for improving semen cryotolerance in rams. - Source: PubMed
Publication date: 2026/02/28
Cinkara Serap DayanBadıllı NidaGüngör İbrahim HalilCihangiroğlu Aslıhan ÇakırAcısu Tutku CanÖzmen Görkem KırmızıkayaArkalı GözdeBulan Mustafa SezerTektemur AhmetToraman EdipKaya Şeyma ÖzerSönmez MustafaGür SeyfettinYüce AbdurraufYılmaz ÖkkeşTürk Gaffari - The most common genes responsible for autosomal recessive nonsyndromic hearing loss (AR-NSHL) are GJB2 and STRC. STRC mutations are associated with mild-to-moderate sensorineural (SNHL) hearing loss and a lack of progression. However, our institutional experience suggested otherwise, prompting this review. - Source: PubMed
Publication date: 2026/02/02
Chan Kenny HNightengale Emily EEkhteraei SetarehSchicke ErickaTong SuhongZhu AustinBurton Barbara K - Pathogenic variants in the STRC gene are among the most common causes of autosomal recessive non-syndromic hearing loss, particularly in cases with mild-to-moderate sensorineural hearing loss (SNHL). Despite its prevalence, the clinical phenotype and natural history of STRC-related SNHL remain undercharacterized due to diagnostic challenges posed by a highly homologous pseudogene, pSTRC. This study included 23 families enrolled in the Yonsei University Hearing Loss cohort. Genetic testing was performed using either targeted deafness gene panels or whole-exome sequencing, followed by multiplex ligation-dependent probe amplification and confirmatory Sanger sequencing. A total of 23 patients with STRC-related SNHL were identified, including 12 with homozygous STRC/CATSPER2 gene deletions and 11 with other combinations of pathogenic variants. Most patients exhibited mild-to-moderate SNHL with flat or gently sloping audiometric configurations, predominantly affecting mid-to-high frequencies. No significant differences in mean PTA thresholds were observed between the two genotypic groups. Longitudinal analysis over a follow-up period of up to 4 years demonstrated stable hearing thresholds in 75% of ears, with no significant progression detected using linear mixed model analysis. Linear regression showed no age-dependent threshold shift in either ear across all genotypic subgroups. In conclusion, STRC-related hearing loss is typically mild-to-moderate, stable over time, and audiometrically similar regardless of genotypic subclassification. Given its subtle phenotype and diagnostic complexity, STRC mutations may be underrecognized without targeted screening. Incorporating STRC-specific MLPA assay into routine genetic diagnostics in patients with mild-to-moderate hearing loss may improve early detection and guide timely precision intervention. - Source: PubMed
Publication date: 2025/12/29
Cheon Tae UkJoo Sun YoungKim Sung HuhnChoi Jae YoungWon DongjuGee Heon YungJung Jinsei - Varicocele, a condition of insufficient oxygen supply to testicular tissue leading to hypoxia, is a major factor contributing to male infertility. This study investigated the potential protective effects of N-acetylcysteine (NAC), a potent antioxidant, on sperm characteristics and hormonal receptor expression in a rat model of varicocele-induced testicular injury. Thirty-two adults male Wistar rats were randomly assigned to four groups: Sham, varicocele, varicocele with NAC treatment (varicocele + NAC), and NAC treatment only (NAC). Serum testosterone, LH, and FSH levels were measured, and sperm characteristics, testicular histology, and expression of some genes involved in sperm motility (Catsper-1 and Catsper-2), germ cell development (FSHR), and steroidogenesis (SF-1 and LHCGR) were evaluated in each group. Results revealed that varicocele significantly decreased serum testosterone levels, while simultaneously decreasing sperm quality, germ cell count, and expression of all the mentioned genes (P < 0.05). Also, the level of LH and FSH was significantly increased (P < 0.05). Notably, NAC treatment significantly improved sperm quality and protected testicular tissue against varicocele, suggesting its potential as a therapeutic agent for male infertility. This study demonstrates that NAC may offer a promising strategy for mitigating testicular damage induced by Varicocele. - Source: PubMed
Publication date: 2025/12/03
Shokoohi MajidNasr Esfahani Mohammad HosseinKhaki Amir AfshinGhazi Soltani GildaAlihemmati AlirezaMohammadzadeh Boukani Linda - The prevalence of deafness-infertility syndrome (DIS) is approximately 1%. Genetic heterogeneity is one cause of homozygous copy number variants (CNVs) involving the CATSPER2 and STRC genes, which are associated with DIS and male infertility. Because the prevalence of DIS in Peru is unknown, we aimed to determine the frequency of carriers of DIS-related genes. In this descriptive crossover study, we evaluated the clinical histories and chromosomal microarray analysis results of patients at the Instituto Nacional de Salud del Niño Breña from 2015 to 2022. All patients with CNVs involving the CATSPER2 and STRC genes were included, and the frequencies of carriers and affected patients were determined using Hardy‒Weinberg equilibrium. Relative frequency differences were calculated using the chi-square test with goodness-of-fit for natural regions and poverty groups in Peru. Of 2,142 patients screened, 35 met the inclusion criteria; according to the results, approximately 367,364 people were estimated to be DIS carriers in Peru, and approximately 57,442 people had deafness and infertility. The proportion of carriers in Peru was similar to that observed in other population studies. Additionally, people in regions with higher poverty rates exhibited a greater carrier frequency, suggesting that a patient's region of origin could be a criterion for DIS screening. - Source: PubMed
Publication date: 2025/11/18
Cuellar Luana Carolina VenturaJascha Kevin Bryan AvilesAbarca-Barriga Hugo Hernan