KCNA7 antibody - C-terminal region (ARP35365_P050)
- Known as:
- KCNA7 (anti-) - C-terminal region (ARP35365_P050)
- Catalog number:
- arp35365_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- KCNA7 antibody - C-terminal region (ARP35365_P050)
Related genes to: KCNA7 antibody - C-terminal region (ARP35365_P050)
- Gene:
- KCNA7 NIH gene
- Name:
- potassium voltage-gated channel subfamily A member 7
- Previous symbol:
- -
- Synonyms:
- Kv1.7, HAK6
- Chromosome:
- 19q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-13
- Date modifiied:
- 2016-10-11
Related products to: KCNA7 antibody - C-terminal region (ARP35365_P050)
Related articles to: KCNA7 antibody - C-terminal region (ARP35365_P050)
- This study aims to mine the TCGA database for differentially expressed genes in recurrent lung cancer tissues, determine the relationship between these recurrent genes and lung cancer at the single-cell level, and identify potential targets for lung cancer treatment. - Source: PubMed
Publication date: 2025/06/11
Li WeiyuanHan DuoCao ChunxiaoXie YuningShen Jingxia - Intervertebral disk (IVD) degeneration is associated with lower back pain and aging; however, the mechanisms underlying age-related changes and the changes in macrophage polarization in aging intervertebral disks require further elucidation. The aim of this study was to evaluate changes in macrophages, the differential expression of senescence genes, and their relationship with hub genes in IVDs during aging in mice. - Source: PubMed
Publication date: 2025/04/08
Wang WeiJiang ChengChen Jiong-HuiChen Yong-LongZhang Zhen-WuYang Zhi-ChaoLi JunLi Xiao-Chuan - In forensic investigations, semen samples are a common form of biological evidence, especially in cases involving sexual assault. Therefore, accurately estimating the age of an individual is crucial in criminal cases. This study presents a novel age estimation model based on semen-specific CpG methylation patterns. A multiplex panel was developed, consisting of 12 CpG sites (PARP14, C5orf25, cg23488376, MXRA5, PFKFB3, DLL1, NOX4, cg12837463, TTC7B, KCNA7, NKX2-1, and SYNE4), which exhibit strong correlations with age. Additionally, this study investigates the resilience of these methylation markers under simulated environmental challenges. We collected ejaculate samples from a diverse cohort of 115 male individuals, aged 20-71 years, who underwent deoxyribonucleic acid extraction and bisulfite conversion. Methylation levels of the selected CpG sites were assessed using a SNaPshot assay, which revealed significant correlations with chronological age. We developed and validated two robust age estimation models through stepwise and enter regression analyses, achieving reliable accuracy with mean absolute errors ranging from 3.81 to 4.1 years. Additionally, the study also investigated the robustness of semen stains under diverse environmental conditions, including fabric type, washing, hematin exposure, and UV-C light. The selected methylation markers demonstrated remarkable resilience despite the challenges posed by washing procedures and environmental exposure, confirming their potential for age estimation in forensic genetics. This research presents successful age estimation models, emphasizing the strong correlations between methylation levels and chronological age. The proposed methodology's accuracy is affirmed through model validation on an independent test set, while also highlighting the resilience of semen stains on fabrics under varying storage and washing conditions. - Source: PubMed
Publication date: 2024/08/20
Er SenaAbik ZehraErsoy GokhanFiloglu GonulOzkara HamdiBulbul Ozlem - Thyroid hormones regulate cardiac functions mainly through direct actions in the heart and by binding to the thyroid hormone receptor (TR) isoforms α1 and β. While the role of the most abundantly expressed isoform, TRα1, is widely studied and well characterized, the role of TRβ in regulating heart functions is still poorly understood, primarily due to the accompanying elevation of circulating thyroid hormone in TRβ knockout mice (TRβ-KO). However, their hyperthyroidism is ameliorated at thermoneutrality, which allows studying the role of TRβ without this confounding factor. Here, we noninvasively monitored heart rate in TRβ-KO mice over several days using radiotelemetry at different housing temperatures (22°C and 30°C) and upon 3,3',5-triiodothyronine (T3) administration in comparison to wild-type animals. TRβ-KO mice displayed normal average heart rate at both 22°C and 30°C with only minor changes in heart rate frequency distribution, which was confirmed by independent electrocardiogram recordings in freely-moving conscious mice. Parasympathetic nerve activity was, however, impaired in TRβ-KO mice at 22°C, and only partly rescued at 30°C. As expected, oral treatment with pharmacological doses of T3 at 30°C led to tachycardia in wild-types, accompanied by broader heart rate frequency distribution and increased heart weight. The TRβ-KO mice, in contrast, showed blunted tachycardia, as well as resistance to changes in heart rate frequency distribution and heart weight. At the molecular level, these observations were paralleled by a blunted cardiac mRNA induction of several important genes, including the pacemaker channels and , as well as . The phenotyping of TRβ-KO mice conducted at thermoneutrality allows novel insights on the role of TRβ in cardiac functions in the absence of the usual confounding hyperthyroidism. Even though TRβ is expressed at lower levels than TRα1 in the heart, our findings demonstrate an important role for this isoform in the cardiac response to thyroid hormones. - Source: PubMed
Publication date: 2024/04/08
Dore RiccardoSentis Sarah ChristineJohann KorneliaLopez-Alcantara NuriaResch JuliaChandrasekar AkilaMüller-Fielitz HelgeMoeller Lars ChristianFuehrer DagmarSchwaninger MarkusObermayer BenediktOpitz RobertMittag Jens - The aim of this study was to confirm the beneficial effects of electrical stimulation on denervated skeletal muscle and explore a novel underlying mechanism. - Source: PubMed
La GaoyanZhou MouwangLim Jae-YoungOh SeunglyulXing HuayiLiu NanYang YanyanLiu XiaoxieZhong Lijun