NMUR2 antibody - N-terminal region (ARP35300_P050)
- Known as:
- NMUR2 (anti-) - N-terminal region (ARP35300_P050)
- Catalog number:
- arp35300_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- NMUR2 antibody - N-terminal region (ARP35300_P050)
Related genes to: NMUR2 antibody - N-terminal region (ARP35300_P050)
- Gene:
- NMUR2 NIH gene
- Name:
- neuromedin U receptor 2
- Previous symbol:
- NMU2R
- Synonyms:
- -
- Chromosome:
- 5q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-24
- Date modifiied:
- 2014-11-19
Related products to: NMUR2 antibody - N-terminal region (ARP35300_P050)
Related articles to: NMUR2 antibody - N-terminal region (ARP35300_P050)
- Neuromedin U (NMU) is an important neuropeptide. The paraventricular nucleus (PVN) is an important central nucleus for regulating the adipose afferent reflex (AAR). In this study, we aimed to investigate the acute effects of NMU in PVN on AAR, sympathetic nerve activity (SNA), blood pressure (BP) and heart rate (HR) in the rats with obesity-related hypertension (OH) induced by a high-fat diet for 16 weeks. - Source: PubMed
Publication date: 2025/10/26
Wang QianZhu Han-XuGao QingXia Chen-XiCao Wen-JuanChen Ai-DongZhou Ye-BoChen Lei-Lei - The objective of this study was to elucidate the role of endogenous Neuromedin U (NMU) in rats by performing NMU knockout (KO). Male, but not female NMU KO rats exhibited decreased wheel-running activity vs wildtype (WT), although overall home cage activity was not affected. Plasma testosterone in WT rats varied significantly over the course of a day, with a peak at ZT1 and a nadir at ZT18, whereas in NMU KO rats testosterone remained stable throughout the day. Chronic administration of testosterone restored wheel-running activity in NMU KO rats to the same level as in WT rats, suggesting that the decrease in wheel-running activity in NMU KO rats is due to the disruption of the diurnal change of testosterone. Accordingly, expression of the luteinizing hormone beta subunit (Lhb) mRNA in the pars distalis of anterior pituitary was significantly lower in NMU KO rats; immunostaining revealed that the size of luteinizing hormone (LH)-expressing cells was also relatively small in those animals. In the brain of male WT rats, Nmu was highly expressed in the pars tuberalis, and the NMU receptor Nmur2 was highly expressed in the ependymal cell layer of the third ventricle. This study reveals a novel function of NMU and indicates that endogenous NMU in rats plays a role in the regulation of motivated activity via regulation of testosterone. - Source: PubMed
Otsuka MaiTakeuchi YuMoriyama MahoEgoshi SakuraGoto YukiGu TingtingKimura Atsushi PHaraguchi ShogoYoshii TaishiTakeuchi SakaeMatsuyama MakotoBentley George EAizawa Sayaka - Identifying genes involved in anxiety is important to elucidate the mechanisms of anxiety disorders. Hatano high avoidance animals (HAA) and low avoidance animals (LAA) are inbred strains that are selected based on their performance in an active avoidance test. HAA shows a higher level of anxiety-like behavior than LAA. The present study focuses on the hippocampus, which is associated with anxiety-like behavior, and used microarray analysis and RT-qPCR to select genes with differential expression in the hippocampus between HAA and LAA (Experiment 1). The microarray analysis revealed differences in 498 gene expressions between HAA and LAA, of which 21 genes were ligand-receptor related in the nervous system. We selected nine genes based on p value and conducted RT-qPCR, which identified seven genes whose expressions were higher in LAA than in HAA. We focused on the gene, neuromedin U receptor 2 (Nmur2), which showed significantly different expression levels between HAA and LAA. Further, we conducted a behavioral test to evaluate anxiety levels by administering neuromedin U (NmU), an agonist for NmUR2, into the hippocampus (Experiment 2). NmU treatment did not affect the results of the open field test or the elevated plus maze test, which are unconditioned response models of anxiety. However, in the passive avoidance test, a conditioned response model of anxiety, the NmU group showed less anxiety-like behavior than the control group. This is the first study to show that NmU suppresses the conditioned response model of anxiety via the hippocampus, indicating that NmUR2 in the hippocampus may be involved in anxiety-like behavior. - Source: PubMed
Sato KaitoIshii AtsuhiroKobayashi ShoheiHatakeyama TaichiWatanabe GenSoga TomokoParhar IshwarMatsuwaki TakashiMoriya ShogoOhta RyoChiba ShuichiKawaguchi Maiko - Amblyopia is characterized by decreased visual acuity due to abnormal visual experience during development. It affects approximately 3% of the population and is associated with abnormal development of the visual cortex. Despite treatment, many patients have residual visual acuity deficits. This study aimed to explore the genetic contributions to amblyopia. - Source: PubMed
Publication date: 2025/01/20
Lee Kyoung A ViolaAboobakar Inas FJain AshishTesdahl Corey DJin KimberlyOke IsdinWhitman Mary C - Stroke is the second leading cause of death worldwide. Although conventional treatments such as thrombolysis and mechanical thrombectomy are effective, their narrow therapeutic window limits long-term neurological recovery. Previous studies have shown that vagus nerve stimulation (VNS) enhances neurological recovery after ischemia/reperfusion (I/R) injury, and neuromedin U (NMU) has neuroprotective effects. This study used a mouse model of cerebral I/R injury to investigate the potential mechanisms of NMU in VNS-mediated neurological improvement. The study consisted of two parts: first, assessing the dynamic expression of NMU and NMUR2, which peaked on day 14 post-I/R. NMUR2 was primarily localized in astrocytes, suggesting that the NMU-NMUR2 signaling pathway plays an important role in astrocyte regulation. Next, interventions with VNS, NMU, and R-PSOP + VNS were conducted to evaluate the role of this pathway in VNS-mediated recovery. The results showed that VNS significantly upregulated NMU and NMUR2 expression, which was blocked by the NMUR2 antagonist R-PSOP. VNS and NMU treatment increased the proportion of A2 astrocytes, reduced A1 astrocytes, and enhanced the expression of VEGF and BDNF, all of which were also blocked by R-PSOP. These findings indicate that the "VNS-NMU-NMUR2-astrocyte A1/A2 polarization-VEGF/BDNF pathway" plays a crucial role in promoting neurovascular remodeling, axonal and dendritic regeneration, and synaptic plasticity, thereby contributing to functional recovery. - Source: PubMed
Publication date: 2024/12/14
Jiang XiaYang WendiLiu GangTang HaoZhang RenziZhang LinaLi ChangqingLi Sheng