GRIK4 Antibody - C-terminal region (ARP35248_P050)
- Known as:
- GRIK4 Antibody - C-terminal region (ARP35248_P050)
- Catalog number:
- arp35248_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- GRIK4 Antibody - C-terminal region (ARP35248_P050)
Related genes to: GRIK4 Antibody - C-terminal region (ARP35248_P050)
- Gene:
- GRIK4 NIH gene
- Name:
- glutamate ionotropic receptor kainate type subunit 4
- Previous symbol:
- GRIK
- Synonyms:
- GluK4, KA1
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-29
- Date modifiied:
- 2019-04-23
Related products to: GRIK4 Antibody - C-terminal region (ARP35248_P050)
Related articles to: GRIK4 Antibody - C-terminal region (ARP35248_P050)
- The mammillary body (MB) has traditionally been regarded as a relay station for the hippocampus and plays a pivotal role in the Papez circuit. However, its molecular and cellular organization remains inadequately characterized. This study focuses on the horizontally symmetrically distributed neurotensin (Nts)-expressing and nitric oxide synthase 1 (Nos1)-expressing neurons in the MB, demonstrating that (encoding a high-affinity kainate receptor subunit) underlies their distinct electrophysiological properties. Within neural circuits, Nts and Nos1 neurons receive excitatory inputs from the ventral subiculum and send parallel excitatory projections to the dorsomedial and ventrolateral subdivisions of the anteroventral thalamus (AV). These 2 cell type-specific circuits are essential for working memory and exhibit selective activation during the maintenance phase with a marked temporal difference. Together, our findings establish a direct link from molecular identity to circuit architecture and cognitive processing by demonstrating that molecularly distinct Nts and Nos1 neurons constitute differential circuits with convergent inputs, divergent outputs, and dissociable roles in working memory maintenance. This work thus reveals a fundamental cross-scale organizational principle-molecule, cell, circuit, function-within the MB. - Source: PubMed
Publication date: 2026/04/22
Guo YiqingLi LanfangHou ZhenyeLu LiTang XiaomeiZeng JinyuChai ChangdongJiang FuliangXiang ZhigaoShen YuhangHe AodiLu YoumingLi Xinyan - Primary dysmenorrhea (PDM) is a common cyclic menstrual pain that significantly affects the quality of life for women. Several epidemiological studies have suggested a potential association between PDM and mental health traits, including stress, depression, and anxiety. However, there is a lack of systematic investigation into whether a causal relationship exists between PDM and mental health phenotypes compared to other physical phenotypes. In this study, we conducted a large-scale phenome study on a cohort of 7401 young female Chinese college students to explore the association between PDM and various physical and mental health phenotypes. Using a multi-phenotype correlation network model, we discovered that the correlation between the PDM phenotypes and mental health phenotypes was the most dominant among the complex inter-connections across different categories of phenotypes. Furthermore, employing a two-sample Mendelian randomization analysis, we systematically elucidated the genomic-level impact of PDM on the mental health traits of young women. Specifically, we identified an increased risk of depression and anxiety associated with PDM, potentially influenced by several Single-nucleotide polymorphism (SNP) variants such as and . This study offers valuable insights into the genetic mechanism through which dysmenorrhea impacts mental health, which contributes to a better understanding of the comprehensive management of PDM and its associated psychological challenges. - Source: PubMed
Publication date: 2025/07/09
Jiangzhou HuitingXu HanpengWen YanqinGuan ZeyiZheng YangJian XueminSong WeichenFahira AamirZhang JinmaiZhang QingZhao YingZhang ManfeiChen JianhuaLi ZhiqiangWang ZhuoShi Yongyong - Autism spectrum disorder (ASD) is a genetically inherited, complex neuropsychiatric developmental condition that impacts a person's ability to learn, interact, and communicate. ASD is currently classified as a heterogeneous disorder, given that the pathophysiology of ASD is yet unknown. The GRIK gene family (GRIK1, GRIK2, GRIK3, GRIK4, and GRIK5) has genetic variants associated with many psychiatric illnesses including; depression, obsessive–compulsive disorder, and autism. The present study is the first to determine the possible association of GRIK1 rs363598 and intergenic rs360932 variants with susceptibility to ASD in Egyptian children and to correlate these variants with different parameters. - Source: PubMed
Publication date: 2025/12/01
Bassiony HebaBaiomy AhmedAhmed DoaaElaraby Nesma MAmmar Tamer H AAshaat Engy A - - Source: PubMed
Publication date: 2025/11/04
Du ChengKanZhang NaXia MinJiang LinLinWeng WenHao - It has been shown previously that repeated positive fighting experience in daily agonistic interactions is accompanied by the development of psychosis-like behavior, with signs of an addiction-like state associated with changes in the expression of genes encoding the proteins involved in the main neurotransmitter events in some brain regions of aggressive male mice. Fighting deprivation (a no-fight period of 2 weeks) causes a significant increase in their aggressiveness. This paper is aimed at studying-after a period of fighting deprivation-the involvement of genes (associated with neurotransmitter systems within the nucleus accumbens) in the above phenomena. The nucleus accumbens is known to participate in reward-related mechanisms of aggression. We found the following differentially expressed genes (DEGs), whose expression significantly differed from that in controls and/or mice with positive fighting experience in daily agonistic interactions followed by fighting deprivation: catecholaminergic genes , , , , , and ; serotonergic genes , , , and ; opioidergic genes , , and ; and glutamatergic genes , , , , , , , and . The expression of DEGs encoding proteins of the GABAergic system in experienced aggressive male mice mostly returned to control levels after fighting deprivation, except for . In light of the conceptual paradigm for analyzing data that was chosen in our study, the aforementioned DEGs associated with the behavioral pathology can be considered responsible for consequences of aggression followed by fighting deprivation, including mechanisms of an aggression relapse. - Source: PubMed
Publication date: 2025/09/03
Kudryavtseva Natalia NSmagin Dmitry ARedina Olga EKovalenko Irina LGalyamina Anna GBabenko Vladimir N