HEXIM1 antibody - C-terminal region (ARP34420_T100)
- Known as:
- HEXIM1 (anti-) - C-terminal region (ARP34420_T100)
- Catalog number:
- arp34420_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- HEXIM1 antibody - C-terminal region (ARP34420_T100)
Related genes to: HEXIM1 antibody - C-terminal region (ARP34420_T100)
- Gene:
- HEXIM1 NIH gene
- Name:
- HEXIM P-TEFb complex subunit 1
- Previous symbol:
- -
- Synonyms:
- CLP-1, HIS1, MAQ1, EDG1
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-27
- Date modifiied:
- 2018-11-15
Related products to: HEXIM1 antibody - C-terminal region (ARP34420_T100)
Related articles to: HEXIM1 antibody - C-terminal region (ARP34420_T100)
- Multisite chronic pain (MCP) is a complex and increasingly prevalent health issue that significantly impairs quality of life. This study aims to identify potential therapeutic targets for MCP through a proteome-wide Mendelian randomization (MR) approach. We conducted a proteome-wide MR to explore the causal associations of plasma proteins with MCP. MCP used data from a genome-wide association study including 387,649 samples. We used protein data from UKB-PPP including 54,219 samples as the discovery analysis, and from Finngen as the replication analysis. Multiple follow-up analyses were used to investigate the potential function of the candidate proteins. Finally, druggability evaluation and phenome-wide MR analysis were used to assess the priority of these targets. We identified 11 plasma proteins significantly associated with MCP. Increased levels of LRP11, BCHE, DAG1, and SUOX exhibited protective effects, while LATS1, CEP170, SLC27A4, HEXIM1, ECM1, C8B, and MST1 increased MCP risk. After multiple validations, ECM1, C8B, LRP11, BCHE has the strongest convincing evidence. Besides, mediation analysis found 4 reliable combinations, revealed the role of plasma proteins in traits influencing MCP. Finally, druggability evaluation and phenome-wide MR indicated that C8B, and BCHE had the highest priority. - Source: PubMed
Gao JunLiu JiaHao - Frailty, a clinical state of increased vulnerability to stressors with aging, imposes significant strain on healthcare systems. Its genetic underpinnings remain incompletely explored, highlighting the need to identify novel therapeutic targets for aging. - Source: PubMed
Publication date: 2026/04/01
Zhong JiaYuYuan MingHaoZhou EnHu Shuo - Enhanced P-TEFb activity is thought to promote cell proliferation by increasing the transcriptional output of RNA polymerase II. The 7SK snRNP complex, which contains LARP7 and HEXIM1, sequesters and inhibits most cellular P-TEFb to prevent premature transcription elongation. Paradoxically, instead of exerting overgrowth effects, biallelic inactivation of LARP7 is linked to Alazami syndrome, a human neurodevelopmental disorder characterized by growth restriction and cognitive impairment. Here, we report that conditional ablation of either Larp7 or Hexim1 in the murine brain reduces the size and impairs the function of the hippocampal dentate gyrus during the neonatal period. Functional analyses reveal that increased P-TEFb activity enhances self-renewal transcriptional programs in transit-amplifying neuronal progenitor cells to limit neurogenesis in developing dentate gyri. These results demonstrate that dysregulated subtissular stem cell dynamics can reconcile increased P-TEFb activity with reduced organ growth, and suggest a translational opportunity for repurposing P-TEFb inhibitors to treat medical conditions affecting dentate gyrus size and function. - Source: PubMed
Publication date: 2026/03/23
Fang YinQiu TongWang PingBai ShujunWang MinYang ChaoWang YanZhang PeixuanWang HeLiu ShanlingXiao XueLi Qintong - Cognitive processes require de novo gene transcription in neurons. Memory requires the rapid and robust transcription of a class of genes called immediate early genes (IEGs). IEG transcription is facilitated by the formation of a poised basal state, in which RNA polymerase II (RNAP2) initiates transcription, but remains paused downstream of the promoter. Upon neuronal depolarization, the paused RNAP2 is released to complete the synthesis of mRNA transcripts, a process stimulated by positive transcription elongation factor b (P-TEFb). In many cell types, P-TEFb is sequestered into a large inactive complex containing Hexamethylene bisacetamide inducible 1 (HEXIM1), but the impact of this interaction on neuronal gene transcription is not yet fully understood. In this study, we found that neuronal expression levels of HEXIM1 mRNA are highly correlated with impaired cognition in Alzheimer's disease. It is also induced in the hippocampus during memory formation, and following depolarization in neurons. The role of HEXIM1 in neuronal gene transcription was then explored in murine neuronal cultures where we found that calcium frees P-TEFb from the HEXIM1 inhibitory complex. Modulation of P-TEFb by inhibiting the activity of the CDK9 subunit of this complex significantly impacts IEG induction, particularly during repeated depolarization. Our findings indicate that HEXIM1 in complex with P-TEFb plays an important role in establishing and resetting the poised RNAP2 state, enabling efficient activation of genes necessary for synaptic plasticity. - Source: PubMed
Publication date: 2026/02/25
Htet MyoEstay-Olmos CamilaHu LanWu YiyangPowers Brian ECampbell Clorissa DRameshwar AishwaryaAhmed Mohamed RHohman Timothy JWang YanlingSchneider Julie ABennett David AMenon VilasDe Jager Philip LKaas Garrett AColbran Roger JGreer Celeste B - Colorectal cancer (CRC) is a malignant disease that poses a significant threat to human health; however, early diagnostic and treatment strategies for it remain limited. Immune evasion is a critical factor contributing to treatment failure in CRC. Various cell subtypes within the tumor microenvironment (TME) play essential roles in this process. However, there is currently a lack of a systematic and novel classification of immune evasion-related cell subtypes and an analysis of their dynamic interaction networks within the CRC TME. This study aims to explore a novel classification of immune evasion-related subtypes in CRC, elucidate their underlying mechanisms, and assess their value for immunotherapy and prognosis. - Source: PubMed
Publication date: 2026/01/21
Gan QixinXu XuanLiu HaifenLi Yuejun