SOX1 antibody - C-terminal region (ARP34352_P050)
- Known as:
- SOX1 (anti-) - C-terminal region (ARP34352_P050)
- Catalog number:
- arp34352_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- SOX1 antibody - C-terminal region (ARP34352_P050)
Related genes to: SOX1 antibody - C-terminal region (ARP34352_P050)
- Gene:
- SOX1 NIH gene
- Name:
- SRY-box 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 13q34
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-30
- Date modifiied:
- 2015-11-23
Related products to: SOX1 antibody - C-terminal region (ARP34352_P050)
Related articles to: SOX1 antibody - C-terminal region (ARP34352_P050)
- Human neural progenitor cells (hNPCs) are promising candidates for neural repair, however, their in vitro expansion commonly relies on Matrigel, a tumor-derived and xenogeneic matrix that limits translational applicability. In this study, we evaluated defined extracellular matrix (ECM) coatings, including poly-L-ornithine (PLO), laminin, PLO/laminin, and collagen IV, as alternatives to Matrigel for hNPC culture under conventional and electrically stimulated conditions. We found that collagen IV consistently supported hNPC viability, proliferation, and maintenance of progenitor markers Nestin and SOX1 at levels comparable to Matrigel and superior to other chemically defined substrates. Enhanced ERK/MAPK signaling on collagen IV suggested integrin-mediated adhesion as a key mechanism underlying sustained cell survival. When applied to conductive indium tin oxide (ITO) neural interfaces, ECM coatings increased surface hydrophilicity without compromising electrical conductivity. Notably, collagen IV coated ITO maintained high hNPC viability and progenitor identity under uniform electrical stimulation. These findings identify collagen IV as a defined, electrically compatible ECM coating for conductive neural interfaces in translational neural engineering. - Source: PubMed
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Li LinPham Ethan KhanhChung Rylee PhoebeSun JindiSong Shang - Human papillomavirus (HPV)-based cervical screening offers stronger protection against cervical intraepithelial neoplasia (CIN) than screening with cytology. DNA methylation tests have been proposed as an alternative triage test to cytology, although there is currently no consensus on the most accurate gene or gene panels ("markers"). - Source: PubMed
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Ellis Laura BurneyTighe JackBowden Sarah JKechagias Konstantinos SParaskevaidi MariaGarg AkankshaParaskevaidis EvangelosArbyn MarcVeroniki Areti AngelikiKalliala IlkkaFlanagan James MKyrgiou Maria - Sleep is a vital process for restoring brain function and is recognized as a fundamental aspect of both physical and mental health. This study aims to assess the molecular mechanisms of insomnia disorder and identify the key dysregulated genes associated with it. - Source: PubMed
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Mansouri VahidArjmand BabakAsri NastaranRazzaghi ZahraRezaei-Tavirani MostafaRazi FaridehBandarian FatemehRobati Reza MRezaei Mitra - The allele represents the strongest genetic risk factor for late-onset Alzheimer's disease (AD), yet its influence on early cellular programs remains poorly understood. In this study, we investigated transcriptional differences between human induced pluripotent stem cells (iPSCs) carrying the or genotype. RNA sequencing revealed pronounced genotype-dependent transcriptional changes, with enrichment of genes associated with neural development and metallothioneins in cells, while genes related to extracellular matrix organization and cell adhesion were downregulated. Protein-protein interaction network analysis confirmed the presence of clusters linked to neurodevelopmental processes and cellular stress responses in cells. Increased expression and nuclear localization of the early neural marker SOX1 further suggest a shift towards early neural lineage commitment in cells. In addition, altered expression of early growth response () transcription factors and reduced TNFR2 protein levels indicated genotype-specific differences in stress and inflammatory signaling pathways. Together, these findings suggest that genotype-dependent alterations in transcriptional regulation, stress responses, and inflammatory signaling may already emerge in pluripotent cells and potentially influence early differentiation programs. - Source: PubMed
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