RBPJL antibody - N-terminal region (ARP34313_T100)
- Known as:
- RBPJL (anti-) - N-terminal region (ARP34313_T100)
- Catalog number:
- arp34313_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- RBPJL antibody - N-terminal region (ARP34313_T100)
Related genes to: RBPJL antibody - N-terminal region (ARP34313_T100)
- Gene:
- RBPJL NIH gene
- Name:
- recombination signal binding protein for immunoglobulin kappa J region like
- Previous symbol:
- RBPSUHL
- Synonyms:
- RBP-L, SUH, SUHL
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2000-12-14
- Date modifiied:
- 2016-04-06
Related products to: RBPJL antibody - N-terminal region (ARP34313_T100)
Related articles to: RBPJL antibody - N-terminal region (ARP34313_T100)
- Milk-production is one of the most important economic traits in dairy goats. Fundamentally, increasing milk-production at the genetic level can provide potential genetic markers for improving milk-production in dairy goats. Previous studies have shown that milk-production traits in dairy goats are highly polygenic and can be influenced by multiple genes. We therefore performed high-throughput sequencing on 350 Saanen dairy goats and conducted a genome-wide association study (GWAS) on the sequencing and production data. A total of 9,667,930 valid SNPs were identified, among which approximately 51% of the mutations were synonymous changes, and apart from unknown mutations, only a few changes affected gene expression. Finally, 318 SNP loci and 244 candidate genes were selected. We selected 10 loci most likely to influence these traits for large-scale population-based identification. Finally, four candidate genes, , , and , were identified as the most likely to affect milk-production traits in dairy goats. To prevent spurious association analyses, we conducted subsequent experiments. Further results showed that the four candidate genes could regulate the proliferation and secretion of dairy goat mammary epithelial cells by regulating MAPK, mTOR and other pathways. These findings provide more valuable genetic markers and a theoretical basis for better understanding the intrinsic mechanisms of dairy goat mammary glands. - Source: PubMed
Publication date: 2025/11/13
Li FuHe YonglongYan HanbingBu JiaqiWang ZhanhangXu XiaolongLi DanniCao BinyunAn Xiaopeng - Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide association study as part of the International FTLD-TDP Whole-Genome Sequencing Consortium, including 985 patients and 3,153 controls compiled from 26 institutions/brain banks in North America, Europe and Australia, and meta-analysis with the Dementia-seq cohort. We confirm UNC13A as the strongest overall FTLD-TDP risk factor and identify TNIP1 as a novel FTLD-TDP risk factor. In subgroup analyzes, we further identify genome-wide significant loci specific to each of the three main FTLD-TDP pathological subtypes (A, B and C), as well as enrichment of risk loci in distinct tissues, brain regions, and neuronal subtypes, suggesting distinct disease aetiologies in each of the subtypes. Rare variant analysis confirmed TBK1 and identified C3AR1, SMG8, VIPR1, RBPJL, L3MBTL1 and ANO9, as novel subtype-specific FTLD-TDP risk genes, further highlighting the role of innate and adaptive immunity and notch signaling pathway in FTLD-TDP, with potential diagnostic and novel therapeutic implications. - Source: PubMed
Publication date: 2025/04/25
Pottier CyrilKüçükali FahriBaker MattBatzler AnthonyJenkins Gregory Dvan Blitterswijk MarkaVicente Cristina TDe Coster WouterWynants SarahVan de Walle PieterRoss Owen AMurray Melissa EFaura JúliaHaggarty Stephen Jvan Rooij Jeroen GjMol Merel OHsiung Ging-Yuek RGraff CarolineÖijerstedt LinnNeumann ManuelaAsmann YanMcDonnell Shannon KBaheti SaurabhJosephs Keith AWhitwell Jennifer LBieniek Kevin FForsberg LeahHeuer HilaryLago Argentina LarioGeier Ethan GYokoyama Jennifer SOddi Alexis PFlanagan MargaretMao QinwenHodges John RKwok John BDomoto-Reilly KimikoSynofzik MatthisWilke CarloOnyike ChiadiDickerson Bradford CEvers Bret MDugger Brittany NMunoz David GKeith JuliaZinman LorneRogaeva EkaterinaSuh EunRanGefen TamarGeula ChangizWeintraub SandraDiehl-Schmid JanineFarlow Martin REdbauer DieterWoodruff Bryan KCaselli Richard JDonker Kaat Laura LHuey Edward DReiman Eric MMead SimonKing AndrewRoeber SigrunNana Alissa LErtekin-Taner NiluferKnopman David SPetersen Ronald CPetrucelli LeonardUitti Ryan JWszolek Zbigniew KRamos Eliana MarisaGrinberg Lea TTempini Maria Luisa GornoRosen Howard JSpina SalvatorePiguet OlivierGrossman MurrayTrojanowski John QKeene C DirkJin Lee-WayPrudlo JohannesGeschwind Daniel HRissman Robert ACruchaga CarlosGhetti BernardinoHalliday Glenda MBeach Thomas GSerrano Geidy EArzberger ThomasHerms JochenBoxer Adam LHonig Lawrence SVonsattel Jean PLopez Oscar LKofler JuliaWhite Charles LGearing MarlaGlass JonathanRohrer Jonathan DIrwin David JLee Edward BVan Deerlin ViviannaCastellani RudolphMesulam Marsel MTartaglia Maria CFinger Elizabeth CTroakes ClaireAl-Sarraj SafaDalgard Clifton LMiller Bruce LSeelaar HarroGraff-Radford Neill RBoeve Bradley FMackenzie Ian Ravan Swieten John CSeeley William WSleegers KristelDickson Dennis WBiernacka Joanna MRademakers Rosa - Bone remodeling maintains the robustness of the bone tissue by balancing bone resorption by osteoclasts and bone formation by osteoblasts. Although these cells together play a crucial role in bone remodeling, only a few reports are available on the common factors involved in the differentiation of the two types of cells. Here, we show family with sequence similarity 102 member A (Fam102a) as a bone-remodeling factor that positively regulates both osteoclast and osteoblast differentiation. Fam102a regulates osteoblast differentiation by controlling recombination signal binding protein for immunoglobulin κ J region-like (Rbpjl). The Fam102a-Rbpjl axis promotes the nuclear translocation of transcription factors and enhances the expression of Osterix, a transcription factor essential for osteoblast differentiation. The deletion of Fam102a or a functional mutation in Rbpjl leads to osteopenia accompanied by reduced osteoblastic bone formation. Thus, the Fam102a-Rbpjl axis plays an important role in osteoblasts and this finding provides insights into bone remodeling. - Source: PubMed
Publication date: 2025/01/02
Yamashita YuHayashi MikihitoLiu AnhaoSasaki FumiyukiTsuchiya YosukeTakayanagi HiroshiSaito MitsuruNakashima Tomoki - Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide association study as part of the International FTLD-TDP Whole-Genome Sequencing Consortium, including 985 cases and 3,153 controls, and meta-analysis with the Dementia-seq cohort, compiled from 26 institutions/brain banks in the United States, Europe and Australia. We confirm as the strongest overall FTLD-TDP risk factor and identify as a novel FTLD-TDP risk factor. In subgroup analyses, we further identify for the first time genome-wide significant loci specific to each of the three main FTLD-TDP pathological subtypes (A, B and C), as well as enrichment of risk loci in distinct tissues, brain regions, and neuronal subtypes, suggesting distinct disease aetiologies in each of the subtypes. Rare variant analysis confirmed and identified , , and as novel subtype specific FTLD-TDP risk genes, further highlighting the role of innate and adaptive immunity and notch signalling pathway in FTLD-TDP, with potential diagnostic and novel therapeutic implications. - Source: PubMed
Publication date: 2024/06/25
Pottier CyrilKüçükali FahriBaker MattBatzler AnthonyJenkins Gregory Dvan Blitterswijk MarkaVicente Cristina TDe Coster WouterWynants SarahVan de Walle PieterRoss Owen AMurray Melissa EFaura JúliaHaggarty Stephen Jvan Rooij Jeroen GjMol Merel OHsiung Ging-Yuek RGraff CarolineÖijerstedt LinnNeumann ManuelaAsmann YanMcDonnell Shannon KBaheti SaurabhJosephs Keith AWhitwell Jennifer LBieniek Kevin FForsberg LeahHeuer HilaryLago Argentina LarioGeier Ethan GYokoyama Jennifer SOddi Alexis PFlanagan MargaretMao QinwenHodges John RKwok John BDomoto-Reilly KimikoSynofzik MatthisWilke CarloOnyike ChiadiDickerson Bradford CEvers Bret MDugger Brittany NMunoz David GKeith JuliaZinman LorneRogaeva EkaterinaSuh EunRanGefen TamarGeula ChangizWeintraub SandraDiehl-Schmid JanineFarlow Martin REdbauer DieterWoodruff Bryan KCaselli Richard JDonker Kaat Laura LHuey Edward DReiman Eric MMead SimonKing AndrewRoeber SigrunNana Alissa LErtekin-Taner NiluferKnopman David SPetersen Ronald CPetrucelli LeonardUitti Ryan JWszolek Zbigniew KRamos Eliana MarisaGrinberg Lea TGorno Tempini Maria LuisaRosen Howard JSpina SalvatorePiguet OlivierGrossman MurrayTrojanowski John QKeene Dirk CLee-Way JinPrudlo JohannesGeschwind Daniel HRissman Robert ACruchaga CarlosGhetti BernardinoHalliday Glenda MBeach Thomas GSerrano Geidy EArzberger ThomasHerms JochenBoxer Adam LHonig Lawrence SVonsattel Jean PLopez Oscar LKofler JuliaWhite Charles LGearing MarlaGlass JonathanRohrer Jonathan DIrwin David JLee Edward BVan Deerlin ViviannaCastellani RudolphMesulam Marsel MTartaglia Maria CFinger Elizabeth CTroakes ClaireAl-Sarraj SafaMiller Bruce LSeelaar HarroGraff-Radford Neill RBoeve Bradley FMackenzie Ian Ravan Swieten John CSeeley William WSleegers KristelDickson Dennis WBiernacka Joanna MRademakers Rosa - Aberrant acinar to ductal metaplasia (ADM), one of the earliest events involved in exocrine pancreatic cancer development, is typically studied using pancreata from genetically engineered mouse models. - Source: PubMed
Publication date: 2023/02/08
Jiang JinmaiHakimjavadi HesamedinBray Julie KPerkins CoreyGosling AlyssadaSilva LaisBulut GamzeAli JamelSetiawan V WendyCampbell-Thompson MarthaChamala SrikarSchmittgen Thomas D