ZMYM4 antibody - N-terminal region (ARP34210_P050)
- Known as:
- ZMYM4 (anti-) - N-terminal region (ARP34210_P050)
- Catalog number:
- arp34210_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZMYM4 antibody - N-terminal region (ARP34210_P050)
Related genes to: ZMYM4 antibody - N-terminal region (ARP34210_P050)
- Gene:
- ZMYM4 NIH gene
- Name:
- zinc finger MYM-type containing 4
- Previous symbol:
- ZNF262
- Synonyms:
- KIAA0425, ZNF198L3, MYM
- Chromosome:
- 1p34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-15
- Date modifiied:
- 2016-10-05
Related products to: ZMYM4 antibody - N-terminal region (ARP34210_P050)
Related articles to: ZMYM4 antibody - N-terminal region (ARP34210_P050)
- Hepatocellular carcinoma (HCC) constitutes approximately 90% of all liver cancer cases. Targeted drugs demonstrate significant potential in the treatment of advanced HCC; however, it is imperative to investigate novel and promising therapeutic targets to overcome the limitations of current targeted therapies. Zinc-finger MYM-type containing 4 (ZMYM4) has frequently been identified as a fusion gene, but the biological function of ZMYM4 in HCC is still unclear. In this study, we utilized The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to investigate the expression levels of ZMYM4 in HCC and to evaluate the correlation between ZMYM4 expression levels and both clinical characteristics and survival outcomes of HCC patients. Subsequently, clinical samples were utilized for further validation. Subsequently, the impact of ZMYM4 knockdown on the malignant progression of HCC cells was examined through a series of in vitro experiments. The specific regulatory relationship between miR-34a-5p and ZMYM4 was confirmed through a luciferase reporter assay. Ultimately, the regulatory effect of miR-34a-5p on ZMYM4 expression in HCC cells was examined. Bioinformatics analysis and clinical sample detection revealed that ZMYM4 expression was significantly upregulated in HCC and correlated with clinical stages and unfavorable prognosis in patients. When ZMYM4 expression was knocked down, the proliferation, migration, and invasion capabilities of HCC cells were significantly inhibited, while the apoptosis rate was markedly increased. Overexpression of ZMYM4 produced opposing effects. In HCC cells, miR-34a-5p directly targets ZMYM4. Upon overexpression of miR-34a-5p, the malignant phenotype of HCC cells was significantly inhibited. Notably, the overexpression of miR-34a-5p partially mitigated the promotional effect of ZMYM4 upregulation on the malignant progression of HCC cells. In conclusion, ZMYM4 is specifically targeted by miR-34a-5p in HCC and promotes the malignant progression of HCC. This suggests that ZMYM4 may serve as a potential biomarker for both the treatment and prognosis of HCC. - Source: PubMed
Publication date: 2025/10/21
Yi QilinZhao ZhenXu MinLiao LiWu TaoChen ShuaiLiu Yu - Lung cancer is the leading cause of death and the most diagnosed cancer worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer; 85% of lung cancer patients are diagnosed with NSCLC. Though numerous treatments for lung cancer have been developed, the 5-year survival rate of patients with NSCLC remains low. Therefore, it is urgent to explore novel targets for NSCLC treatment. Growing evidence has revealed that circular RNAs (circRNAs) contribute to NSCLC progression. Besides, the data of circRNA microarray (GSE158695) has found that hsa_circ_0011536 is downregulated in NSCLC tissues. Nevertheless, the role of hsa_circ_0011536 in NSCLC remains unknown. In this study, RNA 6-methyladenosine (m6A) modification was detected by methylated RNA immunoprecipitation, the interaction of RNAs was determined using miRNA pulldown and luciferase reporter assay, while ferroptosis was identified by Cell Counting Kit-8 assay, intracellular iron content, and malondialdehyde level. Our findings demonstrated that hsa_circ_0011536 was downregulated in NSCLC cell lines. Mechanism investigation revealed that m6A modification enhanced the back-splicing of pre-ZMYM4 to increase hsa_circ_0011536 expression in A549 and NCI-H1299 cells. Moreover, hsa-miR-576-5p was the target of hsa_circ_0011536, while transferrin receptor (TFRC) was the downstream target of hsa-miR-576-5p in A549 and NCI-H1299 cells. Furthermore, hsa_circ_0011536 elevated TFRC expression by sponging hsa-miR-576-5p in A549 and NCI-H1299 cells, identified by luciferase reporter assay. In addition, hsa_circ_0011536 induced ferroptosis through hsa-miR-576-5p in A549 and NCI-H1299 cells. Therefore, this study revealed that m6A-induced hsa_circ_0011536 elevated TFRC expression to induce ferroptosis by sponging hsa-miR-576-5p in NSCLC. These results might provide novel therapeutic targets for NSCLC treatment. - Source: PubMed
Huang JunmingDeng CaijiuZhu HanhanChen XiaofengChen PeixiDu Shaoshan - The genetic underpinnings of elite sprint and power performance remain largely elusive. This study aimed to identify genetic variants associated with this complex trait as well as to understand their functional implications in elite sprint and power performance. We conducted a multi-phase genome-wide association study (GWAS) in world-class sprint and power athletes of West African and East Asian ancestry and their geographically matched controls. We carried out genotype imputation, replications for the top GWAS signal rs10196189 in two European cohorts, and gene-based and tissue-specific functional network analyses. For the first time, we uncovered the G-allele of rs10196189 in the Polypeptide N-Acetylgalactosaminyltransferase 13 (GALNT13) being significantly associated with elite sprint and power performance (P = 2.13E-09 across the three ancestral groups). Moreover, we found that GALNT13 expression level was positively associated with the relative area occupied by fast-twitch muscle fibers in the vastus lateralis muscle. In addition, significant and borderline associations were observed for BOP1, HSF1, STXBP2, GRM7, MPRIP, ZFYVE28, CERS4, and ADAMTS18 in cross-ancestry or ancestry-specific contexts, predominantly expressed in the nervous and hematopoietic systems. From the elite athlete cohorts, we further identified thirty-six previously uncharacterized genes linked to host defence, leukocyte migration, and cellular responses to interferon-gamma, and four genes - UQCRFS1, PTPN6, RALY and ZMYM4 - associated with aging, neurological conditions, and blood disorders. Taken together, these results provide new biological insights into the genetic basis of elite sprint and power performance and, importantly, offer valuable clues to the molecular mechanisms underlying elite athletic performance, health and disease. - Source: PubMed
Publication date: 2025/02/04
Wang GuanFuku NoriyukiMiyamoto-Mikami EriTanaka MasashiMiyachi MotohikoMurakami HarukaMitchell Braxton DMorrison ErrolAhmetov Ildus IGenerozov Edward VFilipenko Maxim LGilep Andrei AGineviciene ValentinaMoran Colin NVenckunas TomasCieszczyk PawelDerave WimPapadimitriou IoannisGarton Fleur CPadmanabhan SandoshPitsiladis Yannis P - Studying the genetic basis of post-traumatic stress disorder (PTSD) can be useful in predicting its risk in a person with a history of severe traumatic stress and in facilitating earlier diagnosis and referral to a specialist. The aim of the study is to review all GWAS studies related to PTSD. In total, 20 studies were included, of which 5 meta-analyses and 9 included war veterans. The functions of genes and their associations were considered, which included single-cell polymorphisms in different groups of genes involved in embryogenesis, neuron formation, and cell functioning, as well as many DNA sequences with non-coding RNA transcribed. The repeatability of the results between studies and replicative samples was studied. Between the studies, the associations were repeated in the (3 studies) (3 studies) genes A new large-scale study with many found associations was considered individually. Studies regarding polygenic risk were also studied, and several studies showed genetic comorbidity with anxiety and bipolar disorder. However, the models developed by the authors explain a small percentage of variance and are weakly repeated in other samples. It may be possible to solve this problem by using larger samples and clearer homogeneous inclusion criteria. Thus, at the moment, there are few GWAS studies of PTSD; they are ambiguous and uninformative compared to the same studies for other mental disorders, but they have further potential for assessing the risks of developing the disease. - Source: PubMed
Zorkina Y AGolubeva E AGurina O IReznik A MMorozova A Y - Superoxide Dismutase 3 (SOD3) scavenges extracellular superoxide giving a hydrogen peroxide metabolite. Both Reactive Oxygen Species diffuse through aquaporins causing oxidative stress and biomolecular damage. SOD3 is differentially expressed in cancer and this research utilises Gene Expression Omnibus data series GSE2109 with 2,158 cancer samples. Genome-wide expression correlation analysis was conducted with SOD3 as the seed gene. Categorical SOD3 Pearson Correlation gene lists incrementing in correlation strength by 0.01 from ρ≥|0.34| to ρ≥|0.41| were extracted from the data. Positively and negatively SOD3 correlated genes were separated for each list and checked for significance against disease overlapping genes in the ClinVar and Orphanet databases via Enrichr. Disease causal genes were added to the relevant gene list and checked against Gene Ontology, Phenotype Ontology, and Elsevier Pathways via Enrichr before the significant ontologies containing causal and non-overlapping genes were reviewed with a literature search for possible disease and oxidative stress associations. 12 significant individually discriminated disorders were identified: Autosomal Dominant Cutis Laxa (p = 6.05x10-7), Renal Tubular Dysgenesis of Genetic Origin (p = 6.05x10-7), Lethal Arteriopathy Syndrome due to Fibulin-4 Deficiency (p = 6.54x10-9), EMILIN-1-related Connective Tissue Disease (p = 6.54x10-9), Holt-Oram Syndrome (p = 7.72x10-10), Multisystemic Smooth Muscle Dysfunction Syndrome (p = 9.95x10-15), Distal Hereditary Motor Neuropathy type 2 (p = 4.48x10-7), Congenital Glaucoma (p = 5.24x210-9), Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome (p = 3.77x10-16), Classical-like Ehlers-Danlos Syndrome type 1 (p = 3.77x10-16), Retinoblastoma (p = 1.9x10-8), and Lynch Syndrome (p = 5.04x10-9). 35 novel (21 unique) genes across 12 disorders were identified: ADNP, AOC3, CDC42EP2, CHTOP, CNN1, DES, FOXF1, FXR1, HLTF, KCNMB1, MTF2, MYH11, PLN, PNPLA2, REST, SGCA, SORBS1, SYNPO2, TAGLN, WAPL, and ZMYM4. These genes are proffered as potential biomarkers or therapeutic targets for the corresponding rare diseases discussed. - Source: PubMed
Publication date: 2024/10/31
Stanworth MarkZhang Shu-Dong