CUX1 antibody - N-terminal region (ARP34139_P050)
- Known as:
- CUX1 (anti-) - N-terminal region (ARP34139_P050)
- Catalog number:
- arp34139_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CUX1 antibody - N-terminal region (ARP34139_P050)
Related genes to: CUX1 antibody - N-terminal region (ARP34139_P050)
- Gene:
- CUX1 NIH gene
- Name:
- cut like homeobox 1
- Previous symbol:
- CUTL1
- Synonyms:
- CDP, CDP1, CUX, CUT, Clox, CDP/Cut, CDP/Cux, Cux/CDP, CASP, GOLIM6
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-13
- Date modifiied:
- 2019-04-23
Related products to: CUX1 antibody - N-terminal region (ARP34139_P050)
Related articles to: CUX1 antibody - N-terminal region (ARP34139_P050)
- Acute myeloid leukemia (AML) has a poor prognosis due to high chemoresistance and recurrence. TRIM24, an E3 ubiquitin ligase, is oncogenic in solid tumors, but its role in AML and regulation of the oncoprotein p110 CUX1 remain unclear. - Source: PubMed
Publication date: 2026/07/17
Ke Zhi-YinLi JieZhong LiangChen ShanLiu Li-RanXu TingLiu Bei-ZhongYu Li-Hua - Second malignant neoplasms (SMNs) are rare but serious late effects in childhood acute lymphoblastic leukemia (ALL) survivors. Mature peripheral T-cell lymphomas involving both the breast and ovary are exceedingly rare, and their relationship with germline predisposition variants remains poorly understood. We report a 17-year-old female, previously treated for high-risk B-cell ALL and in sustained remission, who developed bilateral breast and ovarian masses in 2024. Histopathology and immunohistochemistry confirmed a mature T-cell lymphoma (CD7, CD99, weak CD5/CD3, Ki-67 >90%, TdT). Whole-exome sequencing revealed a germline pathogenic variant (c.1910-2A>T) along with additional likely pathogenic variants (, , , ). The disease progressed rapidly despite CHOP chemotherapy, and the patient died shortly after diagnosis. This report describes an exceptionally rare SMN of peripheral T-cell lymphoma with breast and ovarian involvement in a pediatric leukemia survivor. The coexistence of a germline mutation and additional genomic alterations suggests a multigenic predisposition hypothesis. Early incorporation of next-generation sequencing may uncover molecular vulnerabilities and inform alternative therapeutic strategies in refractory hematologic malignancies. - Source: PubMed
Publication date: 2026/07/07
Alvarez-Palacios OscarOjeda-Campos LuisRodríguez AlfredoDíaz-Juarez Gabriel ErnestoFigueroa-Torres José ManuelJuárez-Velázquez RocíoJuárez-Figueroa UlisesGallardo-Navarro Jorge JohansSegundo-Galvez Luis FabianOcampo-Bárcenas Azucena - Chicken infectious anemia virus (CIAV) causes immunosuppression, aplastic anemia, and lymphoid atrophy in young chicks, causing major economic losses to the poultry industry. Vaccination is the primary strategy for disease control. This study aimed to develop a ferritin-based nanoparticle vaccine displaying CIAV VP1-VP2 proteins and evaluate its protective efficacy in chicks. - Source: PubMed
Publication date: 2026/07/02
Zhang LuluLi ZhijunYan Yu-Mei ChenSun HailiangWei Fanhua - DNA methylation is an epigenetic mechanism that regulates gene function and plays a crucial role in adaptability traits. Unlike commercial chickens, which have been bred for uniform production performance, desi chickens experience varying environmental pressures, shaping their genetic diversity and survival strategies through organized methylation patterns. We compared global DNA methylation profiles between indigenous (Al, Kn, Nb, and Nn) and commercial chickens (Br and Ly) to identify epigenetic factors. In this study, a single cytosine base modification was observed globally in all six breeds, ranging from 11,935,490 to 44,572,168. Each indigenous and commercial chicken breed exhibited a unique methylation pattern. Further analysis revealed that more than 6979 differentially methylated regions (DMRs) were identified in each indigenous breed compared to the commercial layer and broiler. The identified DMR-associated genes (DMGs) revealed various adaptational processes in each breed. The chicken breeds studied showed different levels of methylation across various genes, indicating breed-specific differences. They were inferred as epigenetic markers for traits, which makes them differ between the breeds, like cognitive behavioral (LINGO1, EFNB1 and NFIA), feed intake (CUX1), thermal stress adaptation (CDC37 and ELOVL5), egg production (RUNX1, and CBFA2T3), hyperpigmentation (SLC31A1), osmotic stress adaptation (SIK1 and Rasd1), growth and carcass quality (LINGO1, PTK7, GPHN, LDB2 and FGF14) and feathering pattern (EFNB1). This study extends our understanding of the epigenetic regulatory mechanisms across different chicken breeds and highlights the value of the environmental adaptability of indigenous germplasm. Finally, we suggest that validating these markers by integrating transcriptomic, phenotypic, and ecological data will be critical for the comprehensive integration of epigenetic and phenotypic data into breeding and conservation biology. - Source: PubMed
Publication date: 2026/07/02
Muthusamy MalarmathiPeters Sunday OAkinsola Oludayo MichaelBalasubramanian Raghavendran VKannan Thiruvenkadan ARekaya RomdhaneAggrey Samuel E - The functional architecture of the cerebral cortex relies on the coordination between excitatory projection neurons and inhibitory GABAergic interneurons. While intrinsic programs governing their specification are well-characterized, it remains unclear whether the proper development of interneurons is required to maintain the molecular identity of projection neurons. - Source: PubMed
Publication date: 2026/06/16
Song XiaoleiZhang FengzhuHan DanyuYu JingzheXin XiaomingGuo Rongliang