FABP4 antibody - middle region (ARP33985_P050)
- Known as:
- FABP4 (anti-) - middle region (ARP33985_P050)
- Catalog number:
- arp33985_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- FABP4 antibody - middle region (ARP33985_P050)
Related genes to: FABP4 antibody - middle region (ARP33985_P050)
- Gene:
- FABP4 NIH gene
- Name:
- fatty acid binding protein 4
- Previous symbol:
- -
- Synonyms:
- A-FABP, aP2
- Chromosome:
- 8q21.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2016-01-18
Related products to: FABP4 antibody - middle region (ARP33985_P050)
Related articles to: FABP4 antibody - middle region (ARP33985_P050)
- Recent studies highlight the critical role of cancer-associated fibroblasts (CAFs) in tumor invasion, but research on the regulation of MFAP5+ fibroblasts by the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) remains limited. Therefore, understanding the function, spatial distribution, and communication dynamics of MFAP5+ fibroblasts within the PDAC tumor microenvironment is essential. We used multi-regional single-cell RNA sequencing to examine the biological characteristics of MFAP5+ fibroblasts in PDAC. A pseudo-time analysis technique was then applied to infer the evolution of CAF subtypes. To investigate this functional role and spatial relationship, we employed multiplex immunofluorescence to observe the spatial distribution of MFAP5+ fibroblasts and endothelial cells. Our study investigated PDAC tumor heterogeneity through a comprehensive analysis of 59,829 cells, which integrated our own multi-regional sampling (GSE285264) with publicly available datasets (GSE277782, GSE155698, GSE212966). We found that MFAP5+ fibroblasts were associated with FABP4+ endothelial cells and VWF+ endothelial cells via key tumor-promoting pathways (e.g., TGF-β, VEGF, FGF). Multiplex immunofluorescence and semi-quantitative analysis confirmed increased prevalence of FABP4+ and VWF+ endothelial cells in areas with high MFAP5+ fibroblast expression, along with elevated VEGF and FGF signaling. Our study reveals a potential pro-tumorigenic mechanism of MFAP5+ fibroblasts in PDAC, suggesting that the MFAP5+ fibroblast-endothelial cell axis may represent a potential target for future therapeutic strategies. - Source: PubMed
Publication date: 2026/04/17
Wei WeiZhang WuyangWang MinLiu YuyiMing ShuaiLi MengruCheng PengCao WeiLi JingyuShi DanWang Bin - Obesity promotes metabolic disturbances that contribute to hepatic steatosis, adipose tissue dysfunction, and vascular impairments. Perivascular adipose tissue (PVAT) plays a critical role in vascular homeostasis, yet little is known about plant-derived omega 3 fatty acids modulate PVAT remodeling during obesity. Here, we investigated whether dietary chia oil supplementation, an abundant source of α-linolenic acid, attenuates metabolic, inflammatory, and vascular dysfunction in obese mice. Male C57BL/6J mice were fed a chow (C) or high-fat diet (HF) diet for 14 weeks and a subset of high-fat-fed mice received chia oil (1.5% v/v) from weeks 8-14 (HC). Chia oil improved insulin sensitivity, increased adiponectin levels, and reduced leptin and hepatic triglyceride accumulation. Histological and molecular analyses showed decreased macrovesicular steatosis and FABP4 expression beside increased CPT-1α and PGC-1α, indicating enhanced lipid oxidation. In mesenteric PVAT, chia oil reduced adipocyte hypertrophy and macrophage infiltration while increasing IL-10 and CD206 expression. Functionally, chia oil restored acetylcholine-induced vasodilation, reduced norepinephrine-mediated vasoconstriction, and increased AMPK phosphorylation. Chia oil supplementation ameliorates key features of obesity-associated metabolic dysfunction, supporting ALA-rich oils as promising nutritional strategies against metabolic disease. - Source: PubMed
de Assis-Ferreira AgathaMuniz-Cassuce GabriellyFonte-Faria Thaísde Souza ThamirisCitelli Martade Carvalho Lenize Costa Reis MarinsOgnibene Dayane Teixeirade Bem Graziele FreitasResende Angela CastroBarja-Fidalgo ChristinaVargas da Silva Simone - Rotator cuff repair outcomes are influenced by systemic metabolic status and tear chronicity. Although obesity and delayed surgery are each linked to poorer healing, whether obesity potentiates the detrimental effects of repair delay on tendon-to-bone healing remains incompletely defined. - Source: PubMed
Publication date: 2026/04/14
Wu YukuanLiu QiaonanLi XiangyangAi YixiangZhao ShengjieJi XuanyuLi MengXiu JintaoZhang JingYin ZhanhaiBai Lang - Acute central nervous system infection is highly lethal, yet the mechanisms by which intracellular bacteria infiltrate the brain remain unclear. Phagocytes are central to host defense, but how infected cells facilitate bacterial access to the brain is poorly defined. In this study, we characterize a CD36 Fabp4 Pparg macrophage subset that mediates bacterial penetration of the brain without disrupting the blood-brain barrier. Biomechanical analysis reveals that CD36 macrophages exhibit abundant protrusions and adhesion molecules, enabling resistance to blood flow shear stress and promoting endothelial adhesion. Metabolomic profiling reveals dysregulated lipid metabolism during neuroinvasion, with β-hydroxybutyrate promoting the differentiation and survival of CD36 macrophages. Importantly, ketogenesis exacerbates symptoms during bacterial neuroinvasion, which could be halted by physiological glucose supplementation. Here, we show that intracellular bacteria exploit metabolically reprogrammed macrophages to access the brain, highlighting glycolipid metabolic homeostasis as a potential therapeutic target in bacterial neuroinvasion. - Source: PubMed
Publication date: 2026/04/14
Sha ZhouYang KunFu ShoupengTong XiaoyongYang HuiFang HuilingHe QianqianLi NingShu XinyuLiu QiFu BeibeiLiu JinLi QianZeng HaoZhang XiaokaiYao RuiZhang XushuoGuo WenjinMao XuhuLong MianLin XiaoyuanZou QuanmingWu Haibo - The growth and development of adipose tissue in sheep tails are closely associated with adipocyte proliferation and differentiation. However, the functional role and regulatory mechanisms of the gene in sheep preadipocytes remain incompletely understood. In this study, liposome-mediated transfection was employed to overexpress the gene and assess its effects on the proliferation and differentiation of sheep preadipocytes. The results of the Cell Counting Kit-8 (CCK-8) assay indicated that the overexpression of promoted preadipocyte viability of preadipocytes. Subsequently, this was verified by RT-qPCR analysis, which showed significant upregulation of proliferation marker genes, including ( < 0.001) and Proliferating Cell Nuclear Antigen () ( < 0.01), while mRNA expression increased compared with the control group, though the increase was not statistically significant. During adipogenic induction, the mRNA expression levels of differentiation markers, such as Peroxisome Proliferator-Activated Receptor Gamma (), CCAAT/Enhancer Binding Protein Alpha (), Adipocyte type Fatty Acid Binding Protein 4 (), and , initially increased and then decreased. The expression of all four markers peaked on day 10 of induction, exceeding levels observed in the control group. In vitro experiments showed that affected the proliferation and differentiation of sheep preadipocytes and may be involved in the regulation of tail fat deposition. - Source: PubMed
Publication date: 2026/04/07
Han WeiZhang HuanGao FengyiTian LimingHe ZhaohuaWang GuanZhang ShuhongDi TenggangChang MenghanLi ShaobinZhao FangfangYang Guangli